CD66b

CD66b（cluster of differentiation 66，分化簇66b，也稱為「癌胚抗原相關細胞黏附分子8」，Carcinoembryonic antigen-related cell adhesion molecule 8，縮寫CEACAM8）是一種細胞表面蛋白質，屬於癌胚抗原（CEA）蛋白質家族，通過糖磷脂酰肌醇（GPI）錨定在細胞膜上，在顆粒白血球上高表達，可作為顆粒白血球的標誌物，參與細胞黏附、細胞遷移和病原體識別 。

延伸閱讀

• Khan WN, Frängsmyr L, Teglund S, et al. Identification of three new genes and estimation of the size of the carcinoembryonic antigen family.. Genomics. 1992, 14 (2): 384–90. PMID 1427854. doi:10.1016/S0888-7543(05)80230-7. 
• Oikawa S, Inuzuka C, Kuroki M, et al. A specific heterotypic cell adhesion activity between members of carcinoembryonic antigen family, W272 and NCA, is mediated by N-domains.. J. Biol. Chem. 1991, 266 (13): 7995–8001. PMID 2022629. doi:10.1016/S0021-9258(18)92930-3 可免費查閱. 
• Berling B, Kolbinger F, Grunert F, et al. Cloning of a carcinoembryonic antigen gene family member expressed in leukocytes of chronic myeloid leukemia patients and bone marrow.. Cancer Res. 1990, 50 (20): 6534–9. PMID 2208113. 
• Arakawa F, Kuroki M, Misumi Y, et al. Characterization of a cDNA clone encoding a new species of the nonspecific cross-reacting antigen (NCA), a member of the CEA gene family.. Biochem. Biophys. Res. Commun. 1990, 166 (3): 1063–71. PMID 2306228. doi:10.1016/0006-291X(90)90975-S. 
• Eades-Perner AM, Thompson J, van der Putten H, Zimmermann W. Mice transgenic for the human CGM6 gene express its product, the granulocyte marker CD66b, exclusively in granulocytes.. Blood. 1998, 91 (2): 663–72. PMID 9427723. doi:10.1182/blood.V91.2.663 可免費查閱. 
• Torsteinsdóttir I, Arvidson NG, Hällgren R, Håkansson L. Enhanced expression of integrins and CD66b on peripheral blood neutrophils and eosinophils in patients with rheumatoid arthritis, and the effect of glucocorticoids.. Scand. J. Immunol. 1999, 50 (4): 433–9. PMID 10520185. S2CID 5692060. doi:10.1046/j.1365-3083.1999.00602.x. 
• Oikawa S, Sugiyama M, Kuroki M, et al. Extracellular N-domain alone can mediate specific heterophilic adhesion between members of the carcinoembryonic antigen family, CEACAM6 and CEACAM8.. Biochem. Biophys. Res. Commun. 2001, 278 (3): 564–8. PMID 11095950. doi:10.1006/bbrc.2000.3858. 
• Singer BB, Scheffrahn I, Heymann R, et al. Carcinoembryonic antigen-related cell adhesion molecule 1 expression and signaling in human, mouse, and rat leukocytes: evidence for replacement of the short cytoplasmic domain isoform by glycosylphosphatidylinositol-linked proteins in human leukocytes.. J. Immunol. 2002, 168 (10): 5139–46. PMID 11994468. doi:10.4049/jimmunol.168.10.5139 可免費查閱. 
• Zhao L, Xu S, Peterson C, et al. Purification and characterization of a 95-kDa protein--carcinoembryonic antigen-related cell adhesion molecule 8--from normal human granulocytes.. J. Immunol. Methods. 2002, 270 (1): 27–35. PMID 12379336. doi:10.1016/s0022-1759(02)00215-6. 
• Strausberg RL, Feingold EA, Grouse LH, et al. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.. Proc. Natl. Acad. Sci. U.S.A. 2003, 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. PMC 139241 可免費查閱. PMID 12477932. doi:10.1073/pnas.242603899 可免費查閱. 
• Grimwood J, Gordon LA, Olsen A, et al. The DNA sequence and biology of human chromosome 19.. Nature. 2004, 428 (6982): 529–35. Bibcode:2004Natur.428..529G. PMID 15057824. doi:10.1038/nature02399 可免費查閱. 
• Gerhard DS, Wagner L, Feingold EA, et al. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).. Genome Res. 2004, 14 (10B): 2121–7. PMC 528928 可免費查閱. PMID 15489334. doi:10.1101/gr.2596504. 
• Ramachandran P, Boontheung P, Xie Y, et al. Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry.. J. Proteome Res. 2006, 5 (6): 1493–503. PMID 16740002. doi:10.1021/pr050492k. 

外部連結

• 醫學主題詞表（MeSH）：CEACAM8+protein,+human
• Human CEACAM8 genome location and CEACAM8 gene details page in the UCSC Genome Browser.
• PDBe-KB （頁面存檔備份，存於互聯網檔案館） provides an overview of all the structure information available in the PDB for Human Carcinoembryonic antigen-related cell adhesion molecule 8 (CEACAM8)

CD66b引用了美國國家醫學圖書館提供的數據，這些數據屬於公共領域。