CD1A
檢索資訊框的維基數據項目時發生錯誤
CD1a（Cluster of Differentiation 1a）是身上的一種人類蛋白質，由基因「CD1A」轉譯而成[1]。
該蛋白屬於CD1蛋白家族，為一種穿膜醣蛋白。CD1a與β2-微球蛋白共同構成的異源二聚體（heterodimers）稱為「CD1a複合體」（CD1a complex），在結構上類似MHC I分子。兩者都具有抗原呈現的能力，但CD1a主要呈現的是糖脂類，而MHC分子主要呈現的是多肽類。人類身上的CD1家族基因共有五個，且都集中排列在1號染色體上的某個區域[1]。
臨床意義[編輯]
在抽煙的病人身上，「CD1A」在肺間質的表現會較為顯著[2]。
參考文獻[編輯]
- ↑ 1.0 1.1 Entrez Gene: CD1A CD1a molecule.
- ↑ Pintarelli G, Noci S, Maspero D, Pettinicchio A, Dugo M, De Cecco L, Incarbone M, Tosi D, Santambrogio L, Dragani TA, Colombo F. Cigarette smoke alters the transcriptome of non-involved lung tissue in lung adenocarcinoma patients. Scientific Reports. September 2019, 9 (1): 13039. Bibcode:2019NatSR...913039P. PMC 6736939 可免費查閱. PMID 31506599. doi:10.1038/s41598-019-49648-2.
外部連結[編輯]
- Human CD1A genome location and CD1A gene details page in the UCSC Genome Browser.
- PDB中UniProt可用的所有結構資訊之概述：P06126 (Human T-cell surface glycoprotein CD1a) 在PDBe-KB。
延伸閱讀[編輯]
- Melián A, Beckman EM, Porcelli SA, Brenner MB. Antigen presentation by CD1 and MHC-encoded class I-like molecules.. Curr. Opin. Immunol. 1996, 8 (1): 82–8. PMID 8729450. doi:10.1016/S0952-7915(96)80109-9.
- Park SH, Bendelac A. CD1-restricted T-cell responses and microbial infection.. Nature. 2000, 406 (6797): 788–92. PMID 10963609. S2CID 4373172. doi:10.1038/35021233.
- Brigl M, Brenner MB. CD1: antigen presentation and T cell function.. Annu. Rev. Immunol. 2004, 22 (1): 817–90. PMID 15032598. doi:10.1146/annurev.immunol.22.012703.104608.
- Coventry B, Heinzel S. CD1a in human cancers: a new role for an old molecule.. Trends Immunol. 2004, 25 (5): 242–8. PMID 15099564. doi:10.1016/j.it.2004.03.002.
- Moody DB, Zajonc DM, Wilson IA. Anatomy of CD1-lipid antigen complexes.. Nat. Rev. Immunol. 2005, 5 (5): 387–99. PMID 15864273. S2CID 1387491. doi:10.1038/nri1605.
- Stove V, Verhasselt B. Modelling thymic HIV-1 Nef effects.. Curr. HIV Res. 2006, 4 (1): 57–64. PMID 16454711. doi:10.2174/157016206775197583.
- Quaranta MG, Mattioli B, Giordani L, Viora M. The immunoregulatory effects of HIV-1 Nef on dendritic cells and the pathogenesis of AIDS.. FASEB J. 2006, 20 (13): 2198–208. PMID 17077296. S2CID 3111709. doi:10.1096/fj.06-6260rev.
- Oakey RJ, Watson ML, Seldin MF. Construction of a physical map on mouse and human chromosome 1: comparison of 13 Mb of mouse and 11 Mb of human DNA.. Hum. Mol. Genet. 1993, 1 (8): 613–20. PMID 1301170. doi:10.1093/hmg/1.8.613.
- Martin LH, Calabi F, Lefebvre FA, et al. Structure and expression of the human thymocyte antigens CD1a, CD1b, and CD1c.. Proc. Natl. Acad. Sci. U.S.A. 1988, 84 (24): 9189–93. PMC 299718 可免費查閱. PMID 2447586. doi:10.1073/pnas.84.24.9189 可免費查閱.
- Moseley WS, Watson ML, Kingsmore SF, Seldin MF. CD1 defines conserved linkage group border between human chromosomes 1 and mouse chromosomes 1 and 3.. Immunogenetics. 1989, 30 (5): 378–82. PMID 2478463. S2CID 9361881. doi:10.1007/BF02425278.
- Yu CY, Milstein C. A physical map linking the five CD1 human thymocyte differentiation antigen genes.. EMBO J. 1990, 8 (12): 3727–32. PMC 402056 可免費查閱. PMID 2583117. doi:10.1002/j.1460-2075.1989.tb08548.x.
- Aruffo A, Seed B. Expression of cDNA clones encoding the thymocyte antigens CD1a, b, c demonstrates a hierarchy of exclusion in fibroblasts.. J. Immunol. 1989, 143 (5): 1723–30. PMID 2701945. S2CID 23168239. doi:10.4049/jimmunol.143.5.1723.
- Longley J, Kraus J, Alonso M, Edelson R. Molecular cloning of CD1a (T6), a human epidermal dendritic cell marker related to class I MHC molecules.. J. Invest. Dermatol. 1989, 92 (4): 628–31. PMID 2784820. doi:10.1111/1523-1747.ep12712175 可免費查閱.
- Albertson DG, Fishpool R, Sherrington P, et al. Sensitive and high resolution in situ hybridization to human chromosomes using biotin labelled probes: assignment of the human thymocyte CD1 antigen genes to chromosome 1.. EMBO J. 1988, 7 (9): 2801–5. PMC 457071 可免費查閱. PMID 3053166. doi:10.1002/j.1460-2075.1988.tb03135.x.
- Calabi F, Milstein C. A novel family of human major histocompatibility complex-related genes not mapping to chromosome 6.. Nature. 1986, 323 (6088): 540–3. Bibcode:1986Natur.323..540C. PMID 3093894. S2CID 4274219. doi:10.1038/323540a0.
- Martin LH, Calabi F, Milstein C. Isolation of CD1 genes: a family of major histocompatibility complex-related differentiation antigens.. Proc. Natl. Acad. Sci. U.S.A. 1987, 83 (23): 9154–8. PMC 387093 可免費查閱. PMID 3097645. doi:10.1073/pnas.83.23.9154 可免費查閱.
- Woolfson A, Milstein C. Alternative splicing generates secretory isoforms of human CD1.. Proc. Natl. Acad. Sci. U.S.A. 1994, 91 (14): 6683–7. Bibcode:1994PNAS...91.6683W. PMC 44267 可免費查閱. PMID 7517559. doi:10.1073/pnas.91.14.6683 可免費查閱.
- Han M, Hannick LI, DiBrino M, Robinson MA. Polymorphism of human CD1 genes.. Tissue Antigens. 2000, 54 (2): 122–7 [2023-06-03]. PMID 10488738. doi:10.1034/j.1399-0039.1999.540202.x. （原始內容存檔於2023-04-11）.
- Sugita M, Grant EP, van Donselaar E, et al. Separate pathways for antigen presentation by CD1 molecules.. Immunity. 2000, 11 (6): 743–52. PMID 10626896. doi:10.1016/S1074-7613(00)80148-X 可免費查閱.
CD1A引用了美國國家醫學圖書館提供的數據，這些數據屬於公共領域。
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