SH-BC-893

SH-BC-893
	File:SH-BC-893 structure.png
识别信息
	IUPAC命名法 [(2S,3R)-3-(4-octylphenyl)pyrrolidin-2-yl]methanol; ;
CAS号	1841409-91-3
PubChem CID	126720664;
E编码	{{#property:P628}}
CompTox Dashboard (EPA)	{{#property:P3117}}Module:EditAtWikidata第29行Lua错误：attempt to index field 'wikibase' (a nil value);
ECHA InfoCard	{{#property:P2566}}Module:EditAtWikidata第29行Lua错误：attempt to index field 'wikibase' (a nil value)
化学信息
化学式	C19H31NO
摩尔质量	289.46 g·mol−1
3D模型（JSmol）	交互式图像;
	SMILES CCCCCCCCC1=CC=C(C=C1)[C@H]2CCN[C@@H]2CO;
	InChI InChI=1S/C19H31NO/c1-2-3-4-5-6-7-8-16-9-11-17(12-10-16)18-13-14-20-19(18)15-21/h9-12,18-21H,2-8,13-15H2,1H3/t18-,19-/m1/s1; Key:FCFUUVQZYSWJLH-RTBURBONSA-N;

SH-BC-893是一种含氮有机化合物，分子式C₁₉H₃₁NO，是一种鞘脂类似物，为癌症治疗而研发。^[1]^[2]^[3]^[4]^[5]^[6]

参考文献[编辑]

^ Kim, SM; Roy, SG; Chen, B; Nguyen, TM; McMonigle, RJ; McCracken, AN; Zhang, Y; Kofuji, S; Hou, J; Selwan, E; Finicle, BT; Nguyen, TT; Ravi, A; Ramirez, MU; Wiher, T; Guenther, GG; Kono, M; Sasaki, AT; Weisman, LS; Potma, EO; Tromberg, BJ; Edwards, RA; Hanessian, S; Edinger, AL. Targeting cancer metabolism by simultaneously disrupting parallel nutrient access pathways.. The Journal of clinical investigation. 2016-11-01, 126 (11): 4088–4102. PMID 27669461. doi:10.1172/JCI87148.
^ Finicle, BT; Ramirez, MU; Liu, G; Selwan, EM; McCracken, AN; Yu, J; Joo, Y; Nguyen, J; Ou, K; Roy, SG; Mendoza, VD; Corrales, DV; Edinger, AL. Sphingolipids inhibit endosomal recycling of nutrient transporters by inactivating ARF6.. Journal of cell science. 2018-06-25, 131 (12). PMID 29848659. doi:10.1242/jcs.213314.
^ Kubiniok, P; Finicle, BT; Piffaretti, F; McCracken, AN; Perryman, M; Hanessian, S; Edinger, AL; Thibault, P. Dynamic Phosphoproteomics Uncovers Signaling Pathways Modulated by Anti-oncogenic Sphingolipid Analogs.. Molecular & cellular proteomics : MCP. 2019-03, 18 (3): 408–422. PMID 30482847. doi:10.1074/mcp.RA118.001053.
^ Jayashankar, V; Selwan, E; Hancock, SE; Verlande, A; Goodson, MO; Eckenstein, KH; Milinkeviciute, G; Hoover, BM; Chen, B; Fleischman, AG; Cramer, KS; Hanessian, S; Masri, S; Turner, N; Edinger, AL. Drug-like sphingolipid SH-BC-893 opposes ceramide-induced mitochondrial fission and corrects diet-induced obesity.. EMBO molecular medicine. 2021-08-09, 13 (8): e13086. PMID 34231322. doi:10.15252/emmm.202013086.
^ Finicle, BT; Eckenstein, KH; Revenko, AS; Anderson, BA; Wan, WB; McCracken, AN; Gil, D; Fruman, DA; Hanessian, S; Seth, PP; Edinger, AL. Simultaneous inhibition of endocytic recycling and lysosomal fusion sensitizes cells and tissues to oligonucleotide therapeutics.. Nucleic acids research. 2023-02-28, 51 (4): 1583–1599. PMID 36727438. doi:10.1093/nar/gkad023.
^ Finicle, BT; Perrochon, AS; Chu, B; Buchmeier, MJ; Edinger, AL. Endolysosomal trafficking regulator SH-BC-893 inhibits coronavirus entry in vitro and in vivo.. Scientific reports. 2026-05-11. PMID 42115643. doi:10.1038/s41598-026-51335-y.

[1] Kim, SM; Roy, SG; Chen, B; Nguyen, TM; McMonigle, RJ; McCracken, AN; Zhang, Y; Kofuji, S; Hou, J; Selwan, E; Finicle, BT; Nguyen, TT; Ravi, A; Ramirez, MU; Wiher, T; Guenther, GG; Kono, M; Sasaki, AT; Weisman, LS; Potma, EO; Tromberg, BJ; Edwards, RA; Hanessian, S; Edinger, AL. Targeting cancer metabolism by simultaneously disrupting parallel nutrient access pathways.. The Journal of clinical investigation. 2016-11-01, 126 (11): 4088–4102. PMID 27669461. doi:10.1172/JCI87148.

[2] Finicle, BT; Ramirez, MU; Liu, G; Selwan, EM; McCracken, AN; Yu, J; Joo, Y; Nguyen, J; Ou, K; Roy, SG; Mendoza, VD; Corrales, DV; Edinger, AL. Sphingolipids inhibit endosomal recycling of nutrient transporters by inactivating ARF6.. Journal of cell science. 2018-06-25, 131 (12). PMID 29848659. doi:10.1242/jcs.213314.

[3] Kubiniok, P; Finicle, BT; Piffaretti, F; McCracken, AN; Perryman, M; Hanessian, S; Edinger, AL; Thibault, P. Dynamic Phosphoproteomics Uncovers Signaling Pathways Modulated by Anti-oncogenic Sphingolipid Analogs.. Molecular & cellular proteomics : MCP. 2019-03, 18 (3): 408–422. PMID 30482847. doi:10.1074/mcp.RA118.001053.

[4] Jayashankar, V; Selwan, E; Hancock, SE; Verlande, A; Goodson, MO; Eckenstein, KH; Milinkeviciute, G; Hoover, BM; Chen, B; Fleischman, AG; Cramer, KS; Hanessian, S; Masri, S; Turner, N; Edinger, AL. Drug-like sphingolipid SH-BC-893 opposes ceramide-induced mitochondrial fission and corrects diet-induced obesity.. EMBO molecular medicine. 2021-08-09, 13 (8): e13086. PMID 34231322. doi:10.15252/emmm.202013086.

[5] Finicle, BT; Eckenstein, KH; Revenko, AS; Anderson, BA; Wan, WB; McCracken, AN; Gil, D; Fruman, DA; Hanessian, S; Seth, PP; Edinger, AL. Simultaneous inhibition of endocytic recycling and lysosomal fusion sensitizes cells and tissues to oligonucleotide therapeutics.. Nucleic acids research. 2023-02-28, 51 (4): 1583–1599. PMID 36727438. doi:10.1093/nar/gkad023.

[6] Finicle, BT; Perrochon, AS; Chu, B; Buchmeier, MJ; Edinger, AL. Endolysosomal trafficking regulator SH-BC-893 inhibits coronavirus entry in vitro and in vivo.. Scientific reports. 2026-05-11. PMID 42115643. doi:10.1038/s41598-026-51335-y.

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[6]

识别信息
File:SH-BC-893 structure.png
IUPAC命名法 [(2S,3R)-3-(4-octylphenyl)pyrrolidin-2-yl]methanol
CAS号	1841409-91-3
PubChem CID	126720664
E编码	{{#property:P628}}
CompTox Dashboard (EPA)	{{#property:P3117}}Module:EditAtWikidata第29行Lua错误：attempt to index field 'wikibase' (a nil value)
ECHA InfoCard	{{#property:P2566}}Module:EditAtWikidata第29行Lua错误：attempt to index field 'wikibase' (a nil value)
化学信息
化学式	C₁₉H₃₁NO
摩尔质量	289.46 g·mol⁻¹
3D模型（JSmol）	交互式图像
SMILES CCCCCCCCC1=CC=C(C=C1)[C@H]2CCN[C@@H]2CO
InChI InChI=1S/C19H31NO/c1-2-3-4-5-6-7-8-16-9-11-17(12-10-16)18-13-14-20-19(18)15-21/h9-12,18-21H,2-8,13-15H2,1H3/t18-,19-/m1/s1 Key:FCFUUVQZYSWJLH-RTBURBONSA-N

SH-BC-893

参考文献[编辑]

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