CYP46A1
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细胞色素 P450 46A1(英语:Cytochrome P450 46A1,缩写CYP46A1)也被称为胆固醇24-羟化酶(chilsterol 24-hydroxylase,EC 1.14.13.98),化学式为:C2600H4085O716N705S22Fe[1],是细胞色素P450超家族的一员,由CYP46A1基因编码,是催化胆固醇生成羟基化生成脑甾醇(24S-羟基胆固醇)的酶[2]。
| Cholesterol-24 hydroxylase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| File:Protein CYP46A1 PDB 2Q9F.png Structure of cholesterol-24 hydroxlase (CYP46A1) in Homo sapiens. Based on PyMOL rendering of PDB 2Q9F. | |||||||||
| 标识符 | |||||||||
| 酶学委员会编号(EC编号) | 1.14.13.98 | ||||||||
| 数据库 | |||||||||
| 集成关系酶学数据库(IntEnz) | IntEnz总观 | ||||||||
| 不伦瑞克酶学数据库(BRENDA) | BRENDA进入 | ||||||||
| 专家蛋白质分析系统(ExPASy) | NiceZyme总观 | ||||||||
| 京都基因与基因组百科全书(KEGG) | KEGG进入 | ||||||||
| 元代谢途径数据库(MetaCyc) | 代谢途径 | ||||||||
| PRIAM酶功能特异性谱 | 谱档案 | ||||||||
| 蛋白质数据库(PDB)结构 | 结构生物信息学研究合作实验室PDB PDB欧洲 PDB概述 | ||||||||
| |||||||||
参考文献[编辑]
- ^ Expasy - ProtParam. web.expasy.org. [2026-01-03].
- ^ Russell DW; Halford RW; Ramirez DMO; Shah R; Kotti T. Cholesterol 24-hydroxylase: an enzyme of cholesterol turnover in the brain. Annual Review of Biochemistry. 2009, 78: 1017–1040. PMC 2837268 可免费查阅. PMID 19489738. doi:10.1146/annurev.biochem.78.072407.103859.
外部链接[编辑]
- GeneReviews/NCBI/NIH/UW entry on Cerebrotendinous Xanthomatosis(页面存档备份,存于互联网档案馆)
- 医学主题词表(MeSH):Cytochrome+P-450+CYP27A1
- Human CYP27A1 genome location and CYP27A1 gene details page in the UCSC Genome Browser.