编辑“︁胰酶”︁（章节）

===藥物短缺與替代品===
由於胰酶來源為家豬，其供應並不穩定，導致在不同的市場上曾出現過幾次胰酶的短缺現象。<ref name=PancShort1>{{cite news|author=Pancreatic cancer action |title=Temporary shortage of Creon (Pancreatin) 25k|work= Pancreatic cancer news|date= 2020-04-21 |url=https://pancreaticcanceraction.org/news/temporary-shortage-of-creon-25k/ |access-date=2020-07-15 }}</ref><ref name=PancShort2>{{cite news |author=Mylan |title=Pancreatin - Cambridgeshire and Peterborough CCG |date=2019-02-01 |url=https://www.cambridgeshireandpeterboroughccg.nhs.uk/EasySiteWeb/GatewayLink.aspx?alId=17434 |access-date=2020-07-15 |archive-date=2021-08-28 |archive-url=https://web.archive.org/web/20210828204648/https://www.cambridgeshireandpeterboroughccg.nhs.uk/_resources/assets/attachment/full/0/17434.PDF |url-status=dead }}</ref><ref name=PancShort3>{{cite news |author=Greater Glasgow and Clyde Medicines |title=Medicines Update Primary Care |date=July 2016 |url=http://www.ggcprescribing.org.uk/blog/medicines-update-primary-care-july-2016/ |access-date=2020-07-15 |archive-date=2020-07-15 |archive-url=https://web.archive.org/web/20200715153109/http://www.ggcprescribing.org.uk/blog/medicines-update-primary-care-july-2016/ |url-status=dead }}</ref>

這種情況促使人們開始研究和商業化替代酶源，這些替代品主要透過[[細菌]]或[[真菌]]來生產。但豬源的胰酶替代療法（如Creon、Zenpep等）仍是臨床治療胰外分泌功能不全（EPI）的標準處方。非豬源產品在療效和法規批准方面尚未能完全取代豬源產品。不過，研究持續推進，以解決豬源酵素供應短缺、理論上存在的傳播風險以及患者宗教/飲食限制等問題。<ref name="PancAlt1">{{cite journal | vauthors = Layer P, Keller J | title = Lipase supplementation therapy: standards, alternatives, and perspectives | journal = Pancreas | volume = 26 | issue = 1 | pages = 1–7 | date = January 2003 | pmid = 12499909 | doi = 10.1097/00006676-200301000-00001 | s2cid = 12365426 }}</ref><ref name="PancAlt2">{{cite journal | vauthors = Roxas M | title = The role of enzyme supplementation in digestive disorders | journal = Alternative Medicine Review | volume = 13 | issue = 4 | pages = 307–314 | date = December 2008 | pmid = 19152478 }}</ref>