UBCS039

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UBCS039
File:UBCS039 structure.png
临床资料
药物类别Sirtuin-6 (SIRT6) activator
识别信息
  • 4-pyridin-3-yl-4,5-dihydropyrrolo[1,2-a]quinoxaline
CAS号358721-70-7
PubChem CID
E编码{{#property:P628}}
CompTox Dashboard (EPA)
  • {{#property:P3117}}Module:EditAtWikidata第29行Lua错误:attempt to index field 'wikibase' (a nil value)
ECHA InfoCard{{#property:P2566}}Module:EditAtWikidata第29行Lua错误:attempt to index field 'wikibase' (a nil value)
化学信息
化学式C16H13N3
摩尔质量247.30 g·mol−1
3D模型(JSmol
  • C1=CC=C2C(=C1)NC(C3=CC=CN32)C4=CN=CC=C4
  • InChI=1S/C16H13N3/c1-2-7-14-13(6-1)18-16(12-5-3-9-17-11-12)15-8-4-10-19(14)15/h1-11,16,18H
  • Key:BSOBGTYXYGHUTD-UHFFFAOYSA-N

UBCS039是一种含氮杂环化合物,分子式C16H13N3,可作为二磷酸腺苷核糖基化Sirtuin-6(SIRT6)的激活剂,用于抗炎药。[1][2]

参考文献[编辑]

  1. ^ Wang D, Zhou Y, Yang N, Liu J, Lu L, Gao Z. SIRT6 mitigates acute kidney injury by enhancing lipid metabolism and reducing tubular epithelial cell apoptosis via suppression of the ACMSD signaling pathway. Cellular Signalling. July 2025, 131. PMID 40120964. doi:10.1016/j.cellsig.2025.111757.  已忽略未知参数|article-number= (帮助)
  2. ^ Sinha R, Singh P, Zeng H, Kumar A, Antony VB. Cadmium exposure triggers vimentin phosphorylation via SIRT6-regulated AKT/PI3K signaling pathway in COPD. European Journal of Cell Biology. September 2025, 104 (3). PMID 40609497. doi:10.1016/j.ejcb.2025.151503.  已忽略未知参数|article-number= (帮助)