FTO基因
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FTO基因全称脂肪和肥胖相关基因（Fat mass and obesity-associated），在人类基因组中位于16号染色体，此基因编码的FTO蛋白属AlkB家族（即与细菌的AlkB蛋白同源[1][2]），为α-酮戊二酸依赖性羟化酶[1]。此基因可能与肥胖症有关[3][4]。2011年何川实验室发现FTO蛋白可将mRNA上的N6-甲基腺苷（m6A）去甲基化成腺苷（A），为第一个被发现的mRNA去甲基酶[5][6]。
参考文献[编辑]
- ^ 1.0 1.1 Gerken T, Girard CA, Tung YC, Webby CJ, Saudek V, Hewitson KS, Yeo GS, McDonough MA, Cunliffe S, McNeill LA, Galvanovskis J, Rorsman P, Robins P, Prieur X, Coll AP, Ma M, Jovanovic Z, Farooqi IS, Sedgwick B, Barroso I, Lindahl T, Ponting CP, Ashcroft FM, O'Rahilly S, Schofield CJ. The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase. Science. November 2007, 318 (5855): 1469–72. Bibcode:2007Sci...318.1469G. PMC 2668859 可免费查阅. PMID 17991826. doi:10.1126/science.1151710.
- ^ Sanchez-Pulido L, Andrade-Navarro MA. The FTO (fat mass and obesity associated) gene codes for a novel member of the non-heme dioxygenase superfamily. BMC Biochemistry. November 2007, 8: 23. PMC 2241624 可免费查阅. PMID 17996046. doi:10.1186/1471-2091-8-23.
- ^ Loos RJ, Yeo GS. The bigger picture of FTO: the first GWAS-identified obesity gene. Nature Reviews. Endocrinology. January 2014, 10 (1): 51–61. PMC 4188449 可免费查阅. PMID 24247219. doi:10.1038/nrendo.2013.227.
- ^ Claussnitzer M, Dankel SN, Kim KH, Quon G, Meuleman W, Haugen C, et al. FTO Obesity Variant Circuitry and Adipocyte Browning in Humans. The New England Journal of Medicine. September 2015, 373 (10): 895–907. PMC 4959911 可免费查阅. PMID 26287746. doi:10.1056/NEJMoa1502214.
- ^ Jia G, Fu Y, Zhao X, Dai Q, Zheng G, Yang Y, Yi C, Lindahl T, Pan T, Yang YG, He C. N6-methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO. Nature Chemical Biology. October 2011, 7 (12): 885–7. PMC 3218240 可免费查阅. PMID 22002720. doi:10.1038/nchembio.687.
- ^ Meyer KD, Saletore Y, Zumbo P, Elemento O, Mason CE, Jaffrey SR. Comprehensive analysis of mRNA methylation reveals enrichment in 3' UTRs and near stop codons. Cell. June 2012, 149 (7): 1635–46. PMC 3383396 可免费查阅. PMID 22608085. doi:10.1016/j.cell.2012.05.003.
