Upjohn
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| The Upjohn Company | |
|---|---|
| File:Upjohn Logo.svg | |
| 公司结局 | 与Pharmacia合并为Pharmacia & Upjohn |
| 后继机构 | Pharmacia & Upjohn 晖致（Viatris） |
| 成立 | 1886年 |
| 结束 | 1995年 |
| 总部 | 美国密歇根州波蒂奇 |
| 产业 | 制药产业 |
Upjohn是一家美国制药公司，1886年由威廉·E·厄普约翰在密歇根州黑斯廷斯成立[1]，1995年与瑞典Pharmacia公司合并为Pharmacia & Upjohn，现为辉瑞公司所有。
历史[编辑]
1976年，公司的三位科学家开发了Upjohn双羟基化反应[2]。
产品[编辑]
四位数[编辑]
| 名称 | CAS号 | 分子式 | 化学结构 |
|---|---|---|---|
| 苄非他明 （U-0441） |
156-08-1 | C 17H 21N |
File:Benzphetamine.svg |
| U-0882 | 310-35-0 | C 18H 21NO 2 |
File:U-0882.svg |
| 敌鼠 （U-1363） |
82-66-6 | C 23H 16O 3 |
File:Diphenadione.svg |
| 羧雌醚 （U-2911） |
1755-52-8 | C 17H 22O 3 |
File:Carbestrol.svg |
| U-4527 | 66-81-9 | C 15H 23NO 4 |
File:Cycloheximide.svg |
| U-5956 | 480-49-9 | C 35H 58O 11 |
File:FilipinIII.png |
| U-6040 | 76-43-7 | C 20H 29FO 3 |
File:Fluoxymesterone.svg |
| U-6056 | 13117-35-6 | C 13H 18N 2 |
File:Dimethylhomotryptamine.svg |
| U-8113 | 1688-71-7 | C 10H 13NO |
File:U-8113.svg |
| U-8344 | 66-75-1 | C 8H 11Cl 2N 3O 2 |
File:Uramustine.svg |
| U-8471 | 2668-66-8 | C 22H 32O 3 |
File:Medrysone.svg |
| U-8614 | 426-13-1 | C 22H 29FO 4 |
File:Fluorometholone.svg |
| 醋酸甲羟孕酮 （U-8839） |
71-58-9 | C 24H 34O 4 |
File:Medroxyprogesterone acetate.svg |
| U-8840 | 520-85-4 | C 22H 32O 3 |
File:Medroxyprogesterone.svg |
| 2-氨基-1,1,3-三氰基-1-丙烯 （U-9189） |
868-54-2 | C 6H 4N 4 |
File:Tricyanoaminopropene.svg |
| U-9889 | 18883-66-4 | C 8H 15N 3O 7 |
File:Streptozocin.svg |
五位数[编辑]
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六位数[编辑]
| 名称 | CAS号 | 分子式 | 化学结构 |
|---|---|---|---|
| U-100480 | 168828-58-8 | C 16H 20FN 3O 3S |
File:Sutezolid structure.svg |
| U-101387 | 170858-33-0 | C 21H 27N 3O 3S |
File:Sonepiprazole.svg |
| U-101958 | 170856-57-2 | C 21H 29N 3O |
File:U-101958.svg |
| U-103017 | 166335-18-8 | C 28H 28N 2O 5S |
File:Pnu-103017.svg |
参考文献[编辑]
- ↑ Lohrstorfer, Martha; Larson, Catherine. William E. Upjohn: Person of the Century 1853 - 1932. Kalamazoo Public Library. 2002 [December 24, 2024]. （原始内容存档于May 17, 2008）.
Known by his contemporaries as a dreamer and a tinkerer, Dr. Upjohn saw a need to improve the means of administering medicine. Most medicines of the day were in fluid form, and those in pill form were often hard and insoluble. Patients were left to try to digest the bitter medicine, with no guarantee that it would dissolve in their systems effectively. Dr. Upjohn began experimenting with making better pills in the attic of his home. Eventually he invented his "friable" pill. Friable meant that the pill could easily be crushed to a powder. The pill was patented in 1885, and its reputation quickly spread within the medical community, thanks greatly to Dr. Upjohn's marketing strategy. He sent small pine boards to thousands of physicians along with samples of his rival's hard pills, and his own friable pills. He invited doctors to hammer the pills into the boards to see which one would be the most digestible. This tactic was eventually modified, but for the next 60 years, a thumb reducing an Upjohn pill to powder was used as the trademark symbol of his company, the Upjohn Pill and Granule Company, later more widely known to the world as The Upjohn Company.
- ↑ VanRheenen, V.; Kelly, R.C.; Cha, D.Y. An improved catalytic OsO4 oxidation of olefins to -1,2-glycols using tertiary amine oxides as the oxidant. Tetrahedron Letters. 1976-06, 17 (23): 1973–1976. doi:10.1016/S0040-4039(00)78093-2.
- ↑ 3.0 3.1 ((Lyster, S C.)), ((Duncan, G W.)). ANABOLIC, ANDROGENIC AND MYOTROPIC ACTIVITIES OF DERIVATIVES OF 7α-METHYL-19-NORTESTOSTERONE. Acta Endocrinologica. July 1963, 43 (3): 399–411. doi:10.1530/acta.0.0430399. 温哥华格式错误 (帮助)
- ↑ ((Castañer, J.)), ((Hillier, K.)). U-23,469. Drugs of the Future. 1980, 5 (11): 564. ISSN 0377-8282. doi:10.1358/dof.1980.005.11.1002363.