甘氨酰-脯氨酰-羟脯氨酸

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（重定向自C12H19N3O5）
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甘氨酰-脯氨酰-羟脯氨酸
File:Gly-Pro-Hyp structure.png
识别信息
  • (2S,4R)-1-[(2S)-1-(2-aminoacetyl)pyrrolidine-2-carbonyl]-4-hydroxypyrrolidine-2-carboxylic acid
CAS号2239-67-0
PubChem CID
ChemSpider
UNII
ChEBI
E编码{{#property:P628}}
CompTox Dashboard (EPA)
  • {{#property:P3117}}Module:EditAtWikidata第29行Lua错误：attempt to index field 'wikibase' (a nil value)
ECHA InfoCard{{#property:P2566}}Module:EditAtWikidata第29行Lua错误：attempt to index field 'wikibase' (a nil value)
化学信息
化学式C12H19N3O5
摩尔质量285.30 g·mol−1
3D模型（JSmol）
  • C1C[C@H](N(C1)C(=O)CN)C(=O)N2C[C@@H](C[C@H]2C(=O)O)O
  • InChI=1S/C12H19N3O5/c13-5-10(17)14-3-1-2-8(14)11(18)15-6-7(16)4-9(15)12(19)20/h7-9,16H,1-6,13H2,(H,19,20)/t7-,8+,9+/m1/s1
  • Key:SZEOBSAZWJLOGY-VGMNWLOBSA-N

甘氨酰-脯氨酰-羟脯氨酸（Gly-Pro-Hyp，三肽-29）是一种源自胶原蛋白的三肽。Gly-Pro-Hyp的重复单元构成了胶原蛋白的主要部分，而Gly-Pro-Hyp可以轻易地透过胶原蛋白的部分水解来制备。与Hyp-Gly和Pro-Hyp等其他源自胶原蛋白的小分子二肽一样，Gly-Pro-Hyp被广泛应用于护肤产品中，有时也作为膳食补充剂内服，因为它容易被皮肤吸收并能刺激成纤维细胞合成胶原蛋白，从而有助于伤口愈合，并可能帮助减少衰老迹象。市面上标榜含有“胶原蛋白”的膳食补充剂，通常实际上含有的是胶原蛋白部分水解所产生的低分子量胶原蛋白肽，因为它们比胶原蛋白本身更容易被人体吸收。[1][2][3][4][5][6][7][8]

参见[编辑]

参考文献[编辑]

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  2. ^ Yazaki M, Ito Y, Yamada M, Goulas S, Teramoto S, Nakaya MA, Ohno S, Yamaguchi K. Oral Ingestion of Collagen Hydrolysate Leads to the Transportation of Highly Concentrated Gly-Pro-Hyp and Its Hydrolyzed Form of Pro-Hyp into the Bloodstream and Skin. Journal of Agricultural and Food Chemistry. 2017-03-01, 65 (11): 2315–2322. Bibcode:2017JAFC...65.2315Y. PMID 28244315. doi:10.1021/acs.jafc.6b05679. 
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  4. ^ Chae M, Bae IH, Lim SH, Jung K, Roh J, Kim W. AP Collagen Peptides Prevent Cortisol-Induced Decrease of Collagen Type I in Human Dermal Fibroblasts. International Journal of Molecular Sciences. 2021-04-01, 22 (9): 4788. PMC 8125628 可免费查阅. PMID 33946465. doi:10.3390/ijms22094788 可免费查阅. 
  5. ^ Chae M, Moon CY, Lim SH, Yamashita Y, Yamada H, Ide M, Park CW, Roh J, Kim W. Oral Ingestion of AP Collagen Peptide Leads to Systemic Absorption of Gly-Pro-Hyp, Alleviating H2O2-Induced Dermal Fibroblast Aging. Journal of Medicinal Food. 2023-05-01, 26 (5): 299–306. PMID 37074675. doi:10.1089/jmf.2022.K.0149. 
  6. ^ Yang D, Liu Q, Xu Q, Zheng L, Zhang S, Lu S, Xiao G, Zhao M. Effects of collagen hydrolysates on UV-induced photoaging mice: Gly-Pro-Hyp as a potent anti-photoaging peptide. Food & Function. 2024-03-01, 15 (6): 3008–3022. PMID 38411396. doi:10.1039/d3fo04949c. 
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  8. ^ Kim CE, Lee JS, Kim YH, Shin YC, Shin SK, Kwon EY. Effects of collagen tripeptide supplementation on oxidative stress and mitochondrial function in aging. Nutrition Research and Practice. 2025-12-01, 19 (6): 867–879. PMC 12688003 可免费查阅. PMID 41377595. doi:10.4162/nrp.2025.19.6.867. 
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