SKF-77,434

維基百科,自由的百科全書
跳至導覽 跳至搜尋
SKF-77,434
File:SKF-77,434 Structure.svg
識別資訊
  • 3-allyl-1-phenyl-1,2,4,5-tetrahydro-3-benzazepine-7,8-diol
CAS號104422-04-0
PubChem CID
ChemSpider
UNII
ChEBI
ChEMBL
化學資訊
化學式C19H21NO2
摩爾質量295.38 g·mol−1
3D模型(JSmol
  • c3ccccc3C2CN(CC=C)CCc(cc1O)c2cc1O
  • InChI=1S/C19H21NO2/c1-2-9-20-10-8-15-11-18(21)19(22)12-16(15)17(13-20)14-6-4-3-5-7-14/h2-7,11-12,17,21-22H,1,8-10,13H2
  • Key:QBUVZVXIRYFENV-UHFFFAOYSA-N

SKF-77,434是一種含氮有機化合物,化學式C
19
H
21
NO
2
,屬於多巴胺受體D1的選擇性部分激動劑,能作為興奮劑[1][2][3][4][5][6][7]

參考文獻[編輯]

  1. ^ Grech DM, Spealman RD, Bergman J. Self-administration of D1 receptor agonists by squirrel monkeys. Psychopharmacology. May 1996, 125 (2): 97–104. PMID 8783382. S2CID 36378721. doi:10.1007/BF02249407. 
  2. ^ Weed MR, Paul IA, Dwoskin LP, Moore SE, Woolverton WL. The relationship between reinforcing effects and in vitro effects of D1 agonists in monkeys. The Journal of Pharmacology and Experimental Therapeutics. October 1997, 283 (1): 29–38. PMID 9336305. 
  3. ^ Platt DM, Rowlett JK, Spealman RD. Dissociation of cocaine-antagonist properties and motoric effects of the D1 receptor partial agonists SKF 83959 and SKF 77434. The Journal of Pharmacology and Experimental Therapeutics. June 2000, 293 (3): 1017–26. PMID 10869406. 
  4. ^ Platt DM, Rowlett JK, Spealman RD. Modulation of cocaine and food self-administration by low- and high-efficacy D1 agonists in squirrel monkeys. Psychopharmacology. September 2001, 157 (2): 208–16. PMID 11594448. S2CID 6567384. doi:10.1007/s002130100779. 
  5. ^ Mutschler NH, Bergman J. Effects of chronic administration of the D1 receptor partial agonist SKF 77434 on cocaine self-administration in rhesus monkeys. Psychopharmacology. April 2002, 160 (4): 362–70. PMID 11919663. S2CID 20483120. doi:10.1007/s00213-001-0976-z. 
  6. ^ Desai RI, Terry P, Katz JL. A comparison of the locomotor stimulant effects of D1-like receptor agonists in mice. Pharmacology, Biochemistry, and Behavior. August 2005, 81 (4): 843–8. PMID 16000217. S2CID 2525256. doi:10.1016/j.pbb.2005.06.006. 
  7. ^ Katz JL, Kopajtic TA, Terry P. Effects of dopamine D1-like receptor agonists on food-maintained operant behavior in rats. Behavioural Pharmacology. June 2006, 17 (4): 303–9. PMID 16914948. S2CID 24288989. doi:10.1097/01.fbp.0000205015.67079.f7.