NYX-2925

NYX-2925
	File:NYX-2925 structure.png
臨床資料
藥物類別	選擇性NMDA受體別構調節劑（英語：Allosteric modulator）
ATC碼	未分配;
法律規範狀態
法律規範	美：Investigational New Drug;
識別資訊
	IUPAC命名法 (2S,3R)-3-hydroxy-2-[(4R)-5-(2-methylpropanoyl)-3-oxo-2,5-diazaspiro[3.4]octan-2-yl]butanamide; ;
CAS號	2012536-16-0
PubChem CID	122594417;
IUPHAR/BPS	11289;
DrugBank	DB19149;
ChemSpider	128922021;
UNII	X062KF5ZV3;
ChEMBL	ChEMBL5095189;
化學資訊
化學式	C14H23N3O4
摩爾質量	297.36 g·mol−1
3D模型（JSmol）	交互式圖像;
	SMILES C[C@H]([C@@H](C(=O)N)N1C[C@@]2(C1=O)CCCN2C(=O)C(C)C)O;
	InChI InChI=1S/C14H23N3O4/c1-8(2)12(20)17-6-4-5-14(17)7-16(13(14)21)10(9(3)18)11(15)19/h8-10,18H,4-7H2,1-3H3,(H2,15,19)/t9-,10+,14-/m1/s1; Key:NFXPEHLDVKVVKA-ISTVAULSSA-N;

NYX-2925是一種含氮有機化合物，分子式C
14H
23N
3O
4，是雷帕替奈（英語：Rapastinel）的類似物，可作為選擇性N-甲基-D-天門冬胺酸受體（NMDA受體）別構調節劑（英語：Allosteric modulator），為用做抗抑鬱藥和神經性疼痛藥物而研發。^[1]^[2]^[3]^[4]^[5]

參考文獻[編輯]

^ Khan MA, Houck DR, Gross AL, Zhang XL, Cearley C, Madsen TM, Kroes RA, Stanton PK, Burgdorf J, Moskal JR. NYX-2925 Is a Novel NMDA Receptor-Specific Spirocyclic-β-Lactam That Modulates Synaptic Plasticity Processes Associated with Learning and Memory. The International Journal of Neuropsychopharmacology. March 2018, 21 (3): 242–254. PMC 5838819 可免費查閱. PMID 29099938. doi:10.1093/ijnp/pyx096.
^ Ghoreishi-Haack N, Priebe JM, Aguado JD, Colechio EM, Burgdorf JS, Bowers MS, Cearley CN, Khan MA, Moskal JR. NYX-2925 Is a Novel N-Methyl-d-Aspartate Receptor Modulator that Induces Rapid and Long-Lasting Analgesia in Rat Models of Neuropathic Pain. The Journal of Pharmacology and Experimental Therapeutics. September 2018, 366 (3): 485–497. PMID 29986951. doi:10.1124/jpet.118.249409 可免費查閱.
^ Morrison G, Asiedu MN, Priebe JM, Dunning J, Ghoreishi-Haack N, Kroes RA, Bowers MS, Barth AL, Cearley CN, Moskal JR. The NMDAR modulator NYX-2925 alleviates neuropathic pain via a Src-dependent mechanism in the mPFC. Neurobiology of Pain. 2020, 7. PMC 6938954 可免費查閱. PMID 31909296. doi:10.1016/j.ynpai.2019.100039. 已忽略未知參數|article-number= (幫助)
^ Bowers MS, Cacheaux LP, Sahu SU, Schmidt ME, Sennello JA, Leaderbrand K, Khan MA, Kroes RA, Moskal JR. NYX-2925 induces metabotropic N-methyl-d-aspartate receptor (NMDAR) signaling that enhances synaptic NMDAR and α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor. Journal of Neurochemistry. March 2020, 152 (5): 523–541. PMC 7065110 可免費查閱. PMID 31376158. doi:10.1111/jnc.14845.
^ Zeng Y, Qu ZY, Zhu QW, Wang HY, Zhou Y, Gao ZB. New advances in small molecule drugs targeting NMDA receptors. Acta Pharmacologica Sinica. January 2026, 47 (1): 3–21. PMC 12764577 可免費查閱. PMID 41188625. doi:10.1038/s41401-025-01675-8. 已忽略未知參數|pmc-embargo-date= (幫助)

[1] Khan MA, Houck DR, Gross AL, Zhang XL, Cearley C, Madsen TM, Kroes RA, Stanton PK, Burgdorf J, Moskal JR. NYX-2925 Is a Novel NMDA Receptor-Specific Spirocyclic-β-Lactam That Modulates Synaptic Plasticity Processes Associated with Learning and Memory. The International Journal of Neuropsychopharmacology. March 2018, 21 (3): 242–254. PMC 5838819 可免費查閱. PMID 29099938. doi:10.1093/ijnp/pyx096.

[2] Ghoreishi-Haack N, Priebe JM, Aguado JD, Colechio EM, Burgdorf JS, Bowers MS, Cearley CN, Khan MA, Moskal JR. NYX-2925 Is a Novel N-Methyl-d-Aspartate Receptor Modulator that Induces Rapid and Long-Lasting Analgesia in Rat Models of Neuropathic Pain. The Journal of Pharmacology and Experimental Therapeutics. September 2018, 366 (3): 485–497. PMID 29986951. doi:10.1124/jpet.118.249409 可免費查閱.

[3] Morrison G, Asiedu MN, Priebe JM, Dunning J, Ghoreishi-Haack N, Kroes RA, Bowers MS, Barth AL, Cearley CN, Moskal JR. The NMDAR modulator NYX-2925 alleviates neuropathic pain via a Src-dependent mechanism in the mPFC. Neurobiology of Pain. 2020, 7. PMC 6938954 可免費查閱. PMID 31909296. doi:10.1016/j.ynpai.2019.100039. 已忽略未知參數|article-number= (幫助)

[4] Bowers MS, Cacheaux LP, Sahu SU, Schmidt ME, Sennello JA, Leaderbrand K, Khan MA, Kroes RA, Moskal JR. NYX-2925 induces metabotropic N-methyl-d-aspartate receptor (NMDAR) signaling that enhances synaptic NMDAR and α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor. Journal of Neurochemistry. March 2020, 152 (5): 523–541. PMC 7065110 可免費查閱. PMID 31376158. doi:10.1111/jnc.14845.

[5] Zeng Y, Qu ZY, Zhu QW, Wang HY, Zhou Y, Gao ZB. New advances in small molecule drugs targeting NMDA receptors. Acta Pharmacologica Sinica. January 2026, 47 (1): 3–21. PMC 12764577 可免費查閱. PMID 41188625. doi:10.1038/s41401-025-01675-8. 已忽略未知參數|pmc-embargo-date= (幫助)

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NYX-2925

參考文獻[編輯]

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