CXCL11
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Template:PBB/6373 CXCL11（Template:Langx）化学式为：C368H618O99N106S6[1]，是一小分子的细胞因子属于CXC趋化因子家族[2]，又被称作“干扰素诱导的T细胞a趋化因子”（Interferon-inducible T-cell alpha chemoattractant (I-TAC)[2]。
表达[编辑]
在白细胞，胰腺和肝脏中表达水平高，在胸腺，脾和肺有中等水平的表达，在小肠，胎盘和前列腺中表达水平低[2]。干扰素伽玛和干扰素－b可以在单核细胞[2]，支气管上皮细胞[3]，中性粒细胞[4]，角质形成细胞[5]，和内皮细胞诱导CXCL11的表达。
受体[编辑]
CXCL11结合趋化因子受体CXCR3而起其细胞趋化作用[2][6][7]。CXCL11也可以结合到趋化因子受体CCR3上而阻止CCR3配体的结合[8]。
功能[编辑]
CXCL11对活化的T细胞，中性粒细胞和单核细胞有细胞趋化作用[2]。
参见[编辑]
参考文献[编辑]
- ↑ Template:Cite web
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 Cole et al. Interferon-inducible T cell alpha chemoattractant (I-TAC): a novel non-ELR CXC chemokine with potent activity on activated T cells through selective high affinity binding to CXCR3. J. Exp. Med. 187: 2009-2021, 1998.
- ↑ Sauty, A., Dziejman, M., Taha, R. A., Iarossi, A. S., Neote, K., Garcia-Zepeda, E. A., Hamid, Q., Luster, A. D. (1999) The T cell-specific CXC chemokines IP-10, MIG, and I-TAC are expressed by activated human bronchial epithelial cells J. Immunol. 162,3549-3558
- ↑ Gasperini, S., Marchi, M., Calzetti, F., Laudanna, C., Vicentini, L., Olsen, H., Murphy, M., Liao, F., Farber, J., Cassatella, M. A. (1999) Gene expression and production of the monokine induced by IFN-gamma (MIG), IFN-inducible T cell alpha chemoattractant (I-TAC), and IFN-gamma-inducible protein-10 (IP-10) chemokines by human neutrophils J. Immunol. 162,4928-4937.
- ↑ Tensen, C. P., Flier, J., Van Der Raaij-Helmer, E. M., Sampat-Sardjoepersad, S., Van Der Schors, R. C., Leurs, R., Scheper, R. J., Boorsma, D. M., Willemze, R. (1999) Human IP-9: a keratinocyte-derived high-affinity CXC-chemokine ligand for the IP-10/MIG receptor (CXCR3) J. Invest. Dermatol. 112,716-72.
- ↑ Loetscher M, Gerber B, Loetscher P, Jones SA, Piali L, Clark-Lewis I, Baggiolini M, Moser B. Chemokine receptor specific for IP10 and mig: structure, function, and expression in activated T-lymphocytes. J Exp Med. 1996 Sep 1;184(3):963-9.
- ↑ Weng Y, Siciliano SJ, Waldburger KE, Sirotina-Meisher A, Staruch MJ, Daugherty BL, Gould SL, Springer MS, DeMartino JA. Binding and functional properties of recombinant and endogenous CXCR3 chemokine receptors. J Biol Chem. 1998 Jul 17;273(29):18288-91.
- ↑ Loetscher P, Pellegrino A, Gong JH, Mattioli I, Loetscher M, Bardi G, Baggiolini M, Clark-Lewis I. The ligands of CXC chemokine receptor 3, I-TAC, Mig, and IP10, are natural antagonists for CCR3. J Biol Chem. 2001 Feb 2;276(5):2986-91