CXCL1

Chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
Chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
	File:Protein CXCL1 PDB 1mgs.png PDB rendering based on 1mgs.
有效結構
PDB	直系同源檢索：PDBe, RCSB
PDB查詢代碼列表
	1MGS, 1MSG, 1MSH, 1ROD
標識
代號	CXCL1; FSP; GRO1; GROa; MGSA; MGSA-a; NAP-3; SCYB1
擴展標識	遺傳學：155730 鼠基因：3037818 同源基因：117693 GeneCards: CXCL1 Gene
基因本體論描述
分子功能	· receptor binding; · chemokine activity; · enzyme activator activity; · growth factor activity;
細胞成分	· extracellular region; · extracellular space;
生物過程	· chemotaxis; · inflammatory response; · immune response; · signal transduction; · G-protein coupled receptor signaling pathway; · nervous system development; · cell proliferation; · negative regulation of cell proliferation; · actin cytoskeleton organization; · intracellular signal transduction; · positive regulation of catalytic activity;
	Sources: Amigo / QuickGO
直系同源體
物種	人類
Entrez	2919
Ensembl	ENSG00000163739
UniProt	P09341
mRNA序列	NM_001511
蛋白序列	NP_001502
基因位置	Chr 4:; 74.74 – 74.74 Mb
PubMed查詢	[1]
	閱; 論; 編;

CXCL1（英語：Chemokine (C-X-C motif) ligand 1）是一小分子的細胞因子屬於CXC趨化因子家族^[1]。又被稱作生長調節致癌基因α (Growth-regulated oncogene alpha, GROα)^[1]^[2]^[3]化學式為：C₃₃₇H₅₇₂O₁₀₃N₁₀₂S₅^[4]。趨化因子CXCL1是由巨噬細胞，中性粒細胞和上皮細胞表達的^[5]^[6]。趨化因子CXCL1對中性粒細胞有細胞趨化作用^[1]。CXCL1結合到趨化因子受體CXCR2上而起細胞趨化作用^[7]。人類的CXCL1與許多CXC類的趨化因子基因相鄰聚集在第四染色體上^[8]。CXCL1的主要作用包括新血管形成、炎症反應、傷口癒合^[7]和腫瘤形成^[2]^[3]。

參見[編輯]

參考文獻[編輯]

^ ^1.0 ^1.1 ^1.2 Moser B, Clark-Lewis I, Zwahlen R, Baggiolini M. Neutrophil-activating properties of the melanoma growth-stimulatory activity. J Exp Med. 1990 May 1;171(5):1797-802.
^ ^2.0 ^2.1 Anisowicz, A., Bardwell, L., Sager, R. Constitutive overexpression of a growth-regulated gene in transformed Chinese hamster and human cells. Proc. Nat. Acad. Sci. 84: 7188-7192, 1987.
^ ^3.0 ^3.1 Richmond, A., Thomas, H. G. (1988) Melanoma growth stimulatory activity: isolation from human melanoma tumors and characterization of tissue distribution J. Cell. Biochem. 36,185-198
^ Expasy - ProtParam. web.expasy.org. [2026-02-10].
^ Iida N, Grotendorst GR. Cloning and sequencing of a new gro transcript from activated human monocytes: expression in leukocytes and wound tissue. Mol Cell Biol. 1990 Oct;10(10):5596-9.
^ Becker S, Quay J, Koren HS, Haskill JS. Constitutive and stimulated MCP-1, GRO alpha, beta, and gamma expression in human airway epithelium and bronchoalveolar macrophages. Am J Physiol. 1994 Mar;266(3 Pt 1):L278-86.
^ ^7.0 ^7.1 Devalaraja, R. M., Nanney, L. B., Du, J., Qian, Q., Yu, Y., Devalaraja, M. N., Richmond, A. (2000) Delayed wound healing in CXCR2 knockout mice J. Investig. Dermatol. 115,234-244
^ Richmond A, Balentien E, Thomas HG, Flaggs G, Barton DE, Spiess J, Bordoni R, Francke U, Derynck R. Molecular characterization and chromosomal mapping of melanoma growth stimulatory activity, a growth factor structurally related to beta-thromboglobulin. EMBO J. 1988 Jul;7(7):2025-33.

[mos-1] 1.0 ^1.1 ^1.2 Moser B, Clark-Lewis I, Zwahlen R, Baggiolini M. Neutrophil-activating properties of the melanoma growth-stimulatory activity. J Exp Med. 1990 May 1;171(5):1797-802.

[#1-2] 2.0 ^2.1 Anisowicz, A., Bardwell, L., Sager, R. Constitutive overexpression of a growth-regulated gene in transformed Chinese hamster and human cells. Proc. Nat. Acad. Sci. 84: 7188-7192, 1987.

[#2-3] 3.0 ^3.1 Richmond, A., Thomas, H. G. (1988) Melanoma growth stimulatory activity: isolation from human melanoma tumors and characterization of tissue distribution J. Cell. Biochem. 36,185-198

[4] Expasy - ProtParam. web.expasy.org. [2026-02-10].

[5] Iida N, Grotendorst GR. Cloning and sequencing of a new gro transcript from activated human monocytes: expression in leukocytes and wound tissue. Mol Cell Biol. 1990 Oct;10(10):5596-9.

[6] Becker S, Quay J, Koren HS, Haskill JS. Constitutive and stimulated MCP-1, GRO alpha, beta, and gamma expression in human airway epithelium and bronchoalveolar macrophages. Am J Physiol. 1994 Mar;266(3 Pt 1):L278-86.

[#3-7] 7.0 ^7.1 Devalaraja, R. M., Nanney, L. B., Du, J., Qian, Q., Yu, Y., Devalaraja, M. N., Richmond, A. (2000) Delayed wound healing in CXCR2 knockout mice J. Investig. Dermatol. 115,234-244

[ric-8] Richmond A, Balentien E, Thomas HG, Flaggs G, Barton DE, Spiess J, Bordoni R, Francke U, Derynck R. Molecular characterization and chromosomal mapping of melanoma growth stimulatory activity, a growth factor structurally related to beta-thromboglobulin. EMBO J. 1988 Jul;7(7):2025-33.

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CXCL1

參見[編輯]

參考文獻[編輯]

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