鈣蛋白酶9
（重新導向自CAPN9）
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鈣蛋白酶9（英語：Calpain-9）是一種在人類中由CAPN9基因編碼的蛋白質。[1][2][3]
鈣蛋白酶是普遍存在的、保守的鈣依賴性半胱胺酸蛋白酶家族。鈣蛋白酶是由不變的小亞基和可變的大亞基組成的異二聚體。大亞基具有半胱胺酸蛋白酶結構域，而兩個亞基都具有鈣結合結構域。鈣蛋白酶與神經退行性過程有關，因為它們的活化可以由鈣流入和氧化應激觸發。由該基因編碼的蛋白質主要在胃和小腸中表現，並可能在消化道中具有特殊功能。該基因被認為與胃癌有關。該基因可編碼不同亞型的多個可變剪接轉錄物變體。[3]
參考資料[編輯]
- ↑ Lee HJ, Sorimachi H, Jeong SY, Ishiura S, Suzuki K. Molecular cloning and characterization of a novel tissue-specific calpain predominantly expressed in the digestive tract. Biol Chem. May 1998, 379 (2): 175–184. PMID 9524069. S2CID 37483841. doi:10.1515/bchm.1998.379.2.175.
- ↑ Yoshikawa Y, Mukai H, Hino F, Asada K, Kato I. Isolation of two novel genes, down-regulated in gastric cancer. Jpn J Cancer Res. Jul 2000, 91 (5): 459–63. PMC 5926377 可免費查閱. PMID 10835488. doi:10.1111/j.1349-7006.2000.tb00967.x.
- ↑ 3.0 3.1 Entrez Gene: CAPN9 calpain 9. [2023-01-28]. （原始內容存檔於2010-12-05）.
延伸閱讀[編輯]
- Huang Y, Wang KK. The calpain family and human disease. Trends in Molecular Medicine. 2001, 7 (8): 355–362. PMID 11516996. doi:10.1016/S1471-4914(01)02049-4.
- Suzuki K, Sorimachi H, Yoshizawa T, et al. Calpain: novel family members, activation, and physiologic function. Biol. Chem. Hoppe-Seyler. 1996, 376 (9): 523–9. PMID 8561910. doi:10.1515/bchm3.1995.376.9.523.
- Davis TL, Walker JR, Finerty PJ, et al. The crystal structures of human calpains 1 and 9 imply diverse mechanisms of action and auto-inhibition. J. Mol. Biol. 2007, 366 (1): 216–229. PMID 17157313. doi:10.1016/j.jmb.2006.11.037.
- Strausberg RL, Feingold EA, Grouse LH, et al. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc. Natl. Acad. Sci. U.S.A. 2003, 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. PMC 139241 可免費查閱. PMID 12477932. doi:10.1073/pnas.242603899 可免費查閱.
- Lee HJ, Tomioka S, Kinbara K, et al. Characterization of a human digestive tract-specific calpain, nCL-4, expressed in the baculovirus system. Arch. Biochem. Biophys. 1999, 362 (1): 22–31. PMID 9917325. doi:10.1006/abbi.1998.1021.