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ZEB1 - 版本历史
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'''锌指结构E-box-结合同源框1'''（Zinc finger E-box-binding homeobox 1）是一个由人类[[基因]]''ZEB1''编码的[[蛋白质]]<ref name="pmid1427828">{{Cite journal|title=The TCF8 gene encoding a zinc finger protein (Nil-2-a) resides on human chromosome 10p11.2|date=September 1992|journal=Genomics|issue=1|doi=10.1016/S0888-7543(05)80307-6|volume=14|pages=194–6|pmid=1427828}}</ref><ref name="pmid1840704">{{Cite journal|title=Identification of a zinc finger protein that inhibits IL-2 gene expression|url=https://archive.org/details/sim_science_1991-12-20_254_5039/page/1790|date=December 1991|journal=Science|issue=5039|doi=10.1126/science.1840704|volume=254|pages=1791–4|pmid=1840704}}</ref><ref name="entrez">{{Cite web|url=http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6935|title=Entrez Gene: ZEB1 zinc finger E-box binding homeobox 1}}</ref>。<br />
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ZEB1（以前称为TCF8）编码一种带有[[锌指]]结构域和[[同源框]]结构域的[[转录因子]]，结合位点为[[白细胞介素-2]]基因[[转录|转录起始位点]]上游100个bp处，通过负调控来抑制白介2的表达。<ref name="autogenerated1">{{Cite journal|title=Identification of a zinc finger protein that inhibits IL-2 gene expression|url=https://archive.org/details/sim_science_1991-12-20_254_5039/page/1790|date=December 1991|journal=Science|issue=5039|doi=10.1126/science.1840704|volume=254|pages=1791–4|pmid=1840704}}</ref>。ZEB1和其[[哺乳动物]]中的旁系同源蛋白[[ZEB2]]都属于[[同源框]]转录因子家族中的锌指结构家族中的Zeb家族。ZEB1蛋白质有7个锌指结构和1个[[同源框]]结构<ref name="pmid26464018">{{Cite journal|title=Homeodomain proteins: an update|date=July 2016|journal=Chromosoma|issue=3|doi=10.1007/s00412-015-0543-8|volume=125|pages=497–521|pmc=4901127|pmid=26464018}}</ref>，见右侧图。<br />
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== 临床意义 ==<br />
基因突变对基因与 后多形角膜营养最近的一项研究建议其作出贡献的作用，在 [[肺癌]] 的侵袭和转移的发展。<ref name="pmid24468793">{{Cite journal|title=Inhibition of TBK1 attenuates radiation-induced epithelial-mesenchymal transition of A549 human lung cancer cells via activation of GSK-3β and repression of ZEB1|date=April 2014|journal=Laboratory Investigation; A Journal of Technical Methods and Pathology|issue=4|doi=10.1038/labinvest.2013.153|volume=94|pages=362–70|pmid=24468793}}</ref><br />
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== 参考文献 ==<br />
{{Reflist}}<br />
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== 外部链接 ==<br />
* {{FactorBook|ZEB1}}<br />
{{Transcription factors|g3}}<br />
[[Category:位於10號人類染色體的基因]]<br />
[[Category:转录因子]]</div>
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