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WS-23 - 版本历史
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<p><b>新页面</b></p><div>{{Infobox drug<br />
| image = WS-23_structure.png<br />
| width = <br />
| ATC_prefix =<br />
| ATC_suffix = <br />
| ATC_supplemental = <br />
| legal_status = <br />
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<!-- Chemical and physical data --><br />
| CAS_number = 51115-67-4<br />
| PubChem = 65300<br />
| IUPHAR_ligand = 2474<br />
| ChemSpiderID = 58789<br />
| UNII = 6QOP5A9489<br />
| ChEBI = 169004 <br />
| IUPAC_name = N,2,3-trimethyl-2-propan-2-ylbutanamide<br />
| C = 10<br />
| H = 21<br />
| N = 1<br />
| O = 1<br />
| SMILES = CC(C)C(C)(C(C)C)C(=O)NC<br />
| StdInChI = 1S/C10H21NO/c1-7(2)10(5,8(3)4)9(12)11-6/h7-8H,1-6H3,(H,11,12)<br />
| StdInChIKey = RWAXQWRDVUOOGG-UHFFFAOYSA-N<br />
}}<br />
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'''WS-23'''（甲基二异丙基丙酰胺、2-异丙基-''N'',2,3-三甲基丁酰胺）是一种有机化合物，化学式为[[C10H21NO|C<sub>10</sub>H<sub>21</sub>NO]]。它可作为所谓的“[[薄荷醇]]受体”（[[TRPM8]][[钙离子通道]]）的激活剂（[[通道開放劑|开放剂]]），但其亲和力相对较低，并且也可能作用于其他靶点<ref>{{cite journal | vauthors = Behrendt HJ, Germann T, Gillen C, Hatt H, Jostock R | title = Characterization of the mouse cold-menthol receptor TRPM8 and vanilloid receptor type-1 VR1 using a fluorometric imaging plate reader (FLIPR) assay | url = https://archive.org/details/sim_british-journal-of-pharmacology_2004-02_141_4/page/736 | journal = British Journal of Pharmacology | volume = 141 | issue = 4 | pages = 737–745 | date = February 2004 | pmid = 14757700 | doi = 10.1038/sj.bjp.0705652 | pmc = 1574235 }}</ref><ref>{{cite journal | vauthors = Sherkheli MA, Vogt-Eisele AK, Bura D, Beltrán Márques LR, Gisselmann G, Hatt H | title = Characterization of selective TRPM8 ligands and their structure activity response (S.A.R) relationship | journal = Journal of Pharmacy & Pharmaceutical Sciences | date = 2010 | volume = 13 | issue = 2 | pages = 242–253 | pmid = 20816009 | doi = 10.18433/j3n88n }}</ref>。它具有类似[[薄荷醇]]的清凉效果，常备用作[[電子煙]]组分之一<ref>{{cite journal | vauthors = Leventhal AM, Tackett AP, Whitted L, Jordt SE, Jabba SV | title = Ice flavours and non-menthol synthetic cooling agents in e-cigarette products: a review | journal = Tobacco Control | volume = 32 | issue = 6 | pages = 769–777 | date = November 2023 | pmid = 35483721 | doi = 10.1136/tobaccocontrol-2021-057073 | pmc = 9613790 }}</ref><ref>{{cite journal | vauthors = Tackett AP, Han DH, Peraza N, Whaley RC, Mason T, Cahn R, Hong K, Pang R, Monterosso J, Page MK, Goniewicz ML, Leventhal AM | title = Effects of 'Ice' flavoured e-cigarettes with synthetic cooling agent WS-23 or menthol on user-reported appeal and sensory attributes | journal = Tobacco Control | volume = 34 | issue = 2 | pages = 175–182 | date = April 2025 | pmid = 37940405 | doi = 10.1136/tc-2023-058125 | pmc = 11076411 }}</ref>。<br />
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== 参考文献 ==<br />
{{reflist}}<br />
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[[Category:離子通道開放劑]]<br />
[[Category:酰胺]]<br />
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{{Pharm-stub}}</div>
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