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WS-12 - 版本历史
2026-07-16T22:06:56Z
在这个wiki上该页的修订历史
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imported>Innerstream 来自 2025年8月9日 (六) 00:23
2025-08-09T00:23:44Z
<p></p>
<p><b>新页面</b></p><div>{{Chembox<br />
| ImageFile = Acoltremon.svg<br />
| ImageSize = 200px<br />
| ImageAlt =<br />
| PIN = (1''R'',2''S'',5''R'')-''N''-(4-Methoxyphenyl)-5-methyl-2-(propan-2-yl)cyclohexane-1-carboxamide<br />
| OtherNames =<br />
|Section1={{Chembox Identifiers<br />
| CASNo = 68489-09-8 <br />
| PubChem = 11266244<br />
| SMILES = C[C@@H]1CC[C@H]([C@@H](C1)C(=O)NC2=CC=C(C=C2)OC)C(C)C<br />
| ChemSpiderID = 9441255<br />
| ChEMBL = 2441929<br />
| EC_number = 700-232-9<br />
| UNII = 1L7BVT4Z4Z<br />
| StdInChI = 1S/C18H27NO2/c1-12(2)16-10-5-13(3)11-17(16)18(20)19-14-6-8-15(21-4)9-7-14/h6-9,12-13,16-17H,5,10-11H2,1-4H3,(H,19,20)/t13-,16+,17-/m1/s1<br />
| StdInChIKey = HNSGVPAAXJJOPQ-XOKHGSTOSA-N }}<br />
|Section2={{Chembox Properties<br />
| C=18 | H=27 | N=1 | O=2 <br />
| Appearance =<br />
| Density =<br />
| MeltingPt =<br />
| BoilingPt =<br />
| Solubility = }}<br />
|Section3={{Chembox Hazards<br />
| MainHazards =<br />
| FlashPt =<br />
| AutoignitionPt = }}<br />
}}<br />
<br />
'''{{PAGENAME}}'''，化学式[[C18H27NO2|C<sub>18</sub>H<sub>27</sub>NO<sub>2</sub>]]，是一种[[氮化合物|含氮]][[有机化合物]]，能作为[[离子通道]][[TRPM8]]的强效选择性[[激动剂]]，与[[依色林]]相比，{{PAGENAME}}对TRPM8的激动剂效力略低，但其对TRPM8的选择性却高得多。<ref>{{cite journal | vauthors = Bödding M, Wissenbach U, Flockerzi V | title = Characterisation of TRPM8 as a pharmacophore receptor | journal = Cell Calcium | volume = 42 | issue = 6 | pages = 618–28 | date = December 2007 | pmid = 17517434 | doi = 10.1016/j.ceca.2007.03.005 }}</ref><ref>{{cite journal | vauthors = Sherkheli MA, Vogt-Eisele AK, Bura D, Beltrán Márques LR, Gisselmann G, Hatt H | title = Characterization of selective TRPM8 ligands and their structure activity response (S.A.R) relationship | journal = Journal of Pharmacy & Pharmaceutical Sciences |date=2010| volume = 13 | issue = 2 | pages = 242–53 | pmid = 20816009 | doi = 10.18433/j3n88n | doi-access = free }}</ref><ref>{{cite journal | vauthors = Liu B, Fan L, Balakrishna S, Sui A, Morris JB, Jordt SE | title = TRPM8 is the principal mediator of menthol-induced analgesia of acute and inflammatory pain | journal = Pain | volume = 154 | issue = 10 | pages = 2169–77 | date = October 2013 | pmid = 23820004 | doi = 10.1016/j.pain.2013.06.043 | pmc = 3778045 }}</ref><ref>{{cite journal | vauthors = Peixoto-Neves D, Soni H, Adebiyi A | title = Oxidant-induced increase in norepinephrine secretion from PC12 cells is dependent on TRPM8 channel-mediated intracellular calcium elevation | journal = Biochemical and Biophysical Research Communications | volume = 506 | issue = 3 | pages = 709–715 | date = November 2018 | pmid = 30376995 | doi = 10.1016/j.bbrc.2018.10.120 | s2cid = 53107273 }}</ref><ref>{{cite journal | vauthors = Yin Y, Le SC, Hsu AL, Borgnia MJ, Yang H, Lee SY | title = Structural basis of cooling agent and lipid sensing by the cold-activated TRPM8 channel | journal = Science | volume = 363 | issue = 6430 | date = March 2019 | pmid = 30733385 | doi = 10.1126/science.aav9334| pmc=6478609 | doi-access = free }}</ref><br />
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==参考文献==<br />
{{reflist}}<br />
<br />
==外部链接==<br />
<br />
[[Category:4-甲氧基苯基化合物]]<br />
[[Category:離子通道開放劑]]</div>
imported>Innerstream