imported>Leiem：使用HotCat已添加Category:异𫫇唑啉

2023-01-08T05:46:20Z

新页面

{{Drugbox
| IUPAC_name = 2-(3-phenyl-4,5-dihydro-1,2-oxazol-5-yl)acetic acid
| image = VGX-1027_structure.png

| tradename =
| legal_US =
| legal_status =


| bioavailability =
| metabolism =
| elimination_half-life =
| excretion =


| CAS_number_Ref = {{cascite|correct|CAS}}
| CAS_number = 6501-72-0
| UNII_Ref = {{fdacite|correct|FDA}}
| UNII = AKT814N13R
| PubChem = 10798271
| ChemSpiderID = 8973577
| ChEMBL = 1320667

| C=11 | H=11 | N=1 | O=3
| SMILES = C1C(ON=C1C2=CC=CC=C2)CC(=O)O
| StdInChI=1S/C11H11NO3/c13-11(14)7-9-6-10(12-15-9)8-4-2-1-3-5-8/h1-5,9H,6-7H2,(H,13,14)
| StdInChIKey = MUFJHYRCIHHATF-UHFFFAOYSA-N
}}
'''{{PAGENAMEBASE}}'''也称为GIT-27，分子式为[[C11H11NO3|C11H11NO3]]，是一种[[免疫調節劑]]，可阻断[[TLR2]]、[[TLR4]]、[[TLR6]]等[[Toll样受体]]的下游信号，因此可减少[[白细胞介素|白介素]]、[[肿瘤坏死因子|TNF-α]]等多种[[细胞因子]]造成的影响。<ref>{{cite journal | vauthors = Stojanovic I, Cuzzocrea S, Mangano K, Mazzon E, Miljkovic D, Wang M, Donia M, Al Abed Y, Kim J, Nicoletti F, Stosic-Grujicic S, Claesson M | display-authors = 6 | title = In vitro, ex vivo and in vivo immunopharmacological activities of the isoxazoline compound VGX-1027: modulation of cytokine synthesis and prevention of both organ-specific and systemic autoimmune diseases in murine models | journal = Clinical Immunology | volume = 123 | issue = 3 | pages = 311–23 | date = June 2007 | pmid = 17449326 | doi = 10.1016/j.clim.2007.03.004 }}</ref><ref>{{cite journal | vauthors = Cha JJ, Hyun YY, Lee MH, Kim JE, Nam DH, Song HK, Kang YS, Lee JE, Kim HW, Han JY, Cha DR | display-authors = 6 | title = Renal protective effects of toll-like receptor 4 signaling blockade in type 2 diabetic mice | journal = Endocrinology | volume = 154 | issue = 6 | pages = 2144–55 | date = June 2013 | pmid = 23568555 | doi = 10.1210/en.2012-2080 | doi-access = free }}</ref><ref>{{cite journal | vauthors = Saurus P, Kuusela S, Lehtonen E, Hyvönen ME, Ristola M, Fogarty CL, Tienari J, Lassenius MI, Forsblom C, Lehto M, Saleem MA, Groop PH, Holthöfer H, Lehtonen S | display-authors = 6 | title = Podocyte apoptosis is prevented by blocking the Toll-like receptor pathway | journal = Cell Death & Disease | volume = 6 | pages = e1752 | date = May 2015 | issue = 5 | pmid = 25950482 | doi = 10.1038/cddis.2015.125 | pmc = 4669704 }}</ref><ref>{{cite journal | vauthors = Lee JC, Menacherry S, Diehl MC, Giffear MD, White CJ, Juba R, Bagarazzi ML, Muthumani K, Boyer J, Agarwal V, Nicoletti F, Bart S, Kim JJ, Weiner DB, Sardesai NY | display-authors = 6 | title = Safety, bioavailability, and pharmacokinetics of VGX-1027-A novel oral anti-inflammatory drug in healthy human subjects | journal = Clinical Pharmacology in Drug Development | volume = 5 | issue = 2 | pages = 91–101 | date = March 2016 | pmid = 27138022 | doi = 10.1002/cpdd.193 | s2cid = 22577185 }}</ref><ref>{{cite journal | vauthors = Xu M, Li F, Wang M, Zhang H, Xu L, Adcock IM, Chung KF, Zhang Y | display-authors = 6 | title = Protective effects of VGX-1027 in PM2.5-induced airway inflammation and bronchial hyperresponsiveness | journal = European Journal of Pharmacology | volume = 842 | pages = 373–383 | date = January 2019 | pmid = 30419239 | doi = 10.1016/j.ejphar.2018.11.010 | s2cid = 53292202 | hdl = 10044/1/66292 | hdl-access = free }}</ref><ref>{{cite journal | vauthors = Ahmad SF, Nadeem A, Ansari MA, Bakheet SA, Alasmari F, Alasmari AF, Al-Kharashi LA, Al-Qahtani QH, Attia SM | display-authors = 6 | title = The potent immunomodulatory compound VGX-1027 regulates inflammatory mediators in CD4+ T cells, which are concomitant with the prevention of neuroimmune dysregulation in BTBR T+ Itpr3tf/J mice | journal = Life Sciences | volume = 237 | pages = 116930 | date = November 2019 | pmid = 31610190 | doi = 10.1016/j.lfs.2019.116930 }}</ref>

==参考文献==
{{Reflist|2}}

==外部链接==
{{pharm-stub}}

[[Category:免疫调节药]]
[[Category:羧酸]]
[[Category:异𫫇唑啉]]

VGX-1027 - 版本历史

imported>Leiem：​使用HotCat已添加Category:异𫫇唑啉

imported>Leiem：使用HotCat已添加Category:异𫫇唑啉