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<p><span class="autocomment">結構</span></p> <p><b>新页面</b></p><div>{{Infobox_gene}}<br /> &#039;&#039;&#039;VCAM-1&#039;&#039;&#039;（Vascular cell adhesion protein 1（I型血管細胞黏附蛋白）），又稱&#039;&#039;&#039;[[分化簇|CD]]106&#039;&#039;&#039;，是一種[[细胞粘附分子|細胞黏附蛋白]]，在人體內由&#039;&#039;VCAM-1&#039;&#039;基因編碼，屬於一種[[唾液酸糖蛋白]]&lt;ref name=&quot;Cybulsky_1991&quot;&gt;{{cite journal | vauthors = Cybulsky M, Fries JW, Williams AJ, Sultan P, Eddy RL, Byers MG, Shows TB, ((Gimbrone MA Jr)), Collins T | title = The human VCAM1 gene is assigned to chromosome 1p31-p32 | journal=Cytogenet. Cell Genet. | year = 1991 | volume = 58 | pages = 1852 |doi=10.1159/000133735}}&lt;/ref&gt;。<br /> <br /> ==結構==<br /> VCAM-1含有6個或7個[[免疫球蛋白]]結構域，屬於{{link-en|免疫球蛋白超家族|Immunoglobulin superfamily}}（immunoglobulin superfamily, IgSF）。於人體內存在兩個由[[可變剪接]]產生的[[轉錄本]]&lt;ref name=NCBI&gt;{{cite web | title = Entrez Gene: VCAM1 vascular cell adhesion molecule 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&amp;Cmd=ShowDetailView&amp;TermToSearch=7412| accessdate = }}&lt;/ref&gt;。<br /> <br /> ==功能與分佈==<br /> VCAM-1參與淋巴細胞—內皮細胞間黏附過程和細胞間信號識別過程，能在免疫應答中促進淋巴細胞向炎症區遷移&lt;ref&gt;{{cite web|url=http://www.uniprot.org/uniprot/P19320|title=VCAM1|publisher=Uniprot|access-date=2018-01-10|archive-date=2017-10-03|archive-url=https://web.archive.org/web/20171003023546/http://www.uniprot.org/uniprot/P19320}}&lt;/ref&gt;。[[淋巴細胞]]、[[軟骨細胞]]等細胞中都含有VCAM-1，血管內皮細胞在受到[[細胞因子]]刺激後也會表達VCAM-1蛋白&lt;ref name=NCBI/&gt;&lt;ref&gt;{{cite journal|journal=Arthritis Rheum. 1998 Jul;41(7):1296-305.|title=Vascular cell adhesion molecule 1 (CD106) on primary human articular chondrocytes: functional regulation of expression by cytokines and comparison with intercellular adhesion molecule 1 (CD54) and very late activation antigen 2|author1=Kienzle G.|author2=von Kempis J.}}&lt;/ref&gt;。一些[[間充質幹細胞]]亞群細胞表面表達CD106（VCAM-1）&lt;ref&gt;{{cite journal|title=CD106 identifies a subpopulation of mesenchymal stem cells with unique immunomodulatory properties|author1=ZX Yang|author2=etal|journal=[[PLoS One]]. 2013;8(3):e59354}}&lt;/ref&gt;。<br /> <br /> ==參考==<br /> {{reflist}}<br /> {{Clusters of differentiation}}<br /> {{Cell adhesion molecules}}<br /> [[Category:分化群]]<br /> [[Category:幹細胞]]<br /> [[Category:免疫球蛋白超家族]]</div>

imported>JimGrassroot