imported>Htmlzycq：/* 五位数 */

2026-05-28T00:44:31Z

五位数

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{{Infobox company
| name = The Upjohn Company
| logo = Upjohn Logo.svg
| image =
| image_caption =
| fate = 与[[Pharmacia]]合并为[[Pharmacia & Upjohn]]
| successor = [[Pharmacia & Upjohn]] [[晖致]]（Viatris）
| traded_as =
| foundation = {{Start date|1886}}
| industry = [[制药产业]]
| defunct = {{end date and age|1995}}
| location = 美国密歇根州[[波蒂奇 (密歇根州)|波蒂奇]]
| area_served =
| key_people =
| products =
| revenue =
| operating_income =
| net_income =
| assets =
| equity =
| num_employees =
| subsid =
| homepage =
| footnotes =
}}
[[File:Upjohn's Friable Pills.jpg|thumb|Upjohn的早期Logo]]
'''{{PAGENAME}}'''是一家美国[[制药产业|制药公司]]，1886年由[[威廉·E·厄普约翰]]在[[密歇根州]][[黑斯廷斯 (密歇根州)|黑斯廷斯]]成立<ref>{{cite web | archive-date=May 17, 2008 | archive-url=https://web.archive.org/web/20080517060135/https://www.kpl.gov/collections/LocalHistory/AllAbout/biography/Upjohn.aspx | url=http://www.kpl.gov/collections/LocalHistory/AllAbout/biography/Upjohn.aspx | title=William E. Upjohn: Person of the Century 1853 - 1932 | publisher=Kalamazoo Public Library | date=2002 | accessdate=December 24, 2024 | last=Lohrstorfer | first=Martha | last2=Larson | first2=Catherine | quote=Known by his contemporaries as a dreamer and a tinkerer, Dr. Upjohn saw a need to improve the means of administering medicine. Most medicines of the day were in fluid form, and those in pill form were often hard and insoluble. Patients were left to try to digest the bitter medicine, with no guarantee that it would dissolve in their systems effectively. Dr. Upjohn began experimenting with making better pills in the attic of his home. Eventually he invented his "friable" pill. Friable meant that the pill could easily be crushed to a powder. The pill was patented in 1885, and its reputation quickly spread within the medical community, thanks greatly to Dr. Upjohn's marketing strategy. He sent small pine boards to thousands of physicians along with samples of his rival's hard pills, and his own friable pills. He invited doctors to hammer the pills into the boards to see which one would be the most digestible. This tactic was eventually modified, but for the next 60 years, a thumb reducing an Upjohn pill to powder was used as the trademark symbol of his company, the Upjohn Pill and Granule Company, later more widely known to the world as The Upjohn Company.}}</ref>，1995年与瑞典[[Pharmacia]]公司合并为[[Pharmacia & Upjohn]]，现为[[輝瑞]]公司所有。

==历史==
1976年，公司的三位科学家开发了[[Upjohn双羟基化反应]]<ref>{{cite journal |last1=VanRheenen |first1=V. |last2=Kelly |first2=R.C. |last3=Cha |first3=D.Y. |title=An improved catalytic OsO4 oxidation of olefins to -1,2-glycols using tertiary amine oxides as the oxidant |journal=Tetrahedron Letters |date=1976-06 |volume=17 |issue=23 |pages=1973–1976 |doi=10.1016/S0040-4039(00)78093-2}}</ref>。

==产品==
===四位数===
{| class="wikitable sortable"
|-
! 名称 !! CAS号 !! 分子式 !! 化学结构
|-
| [[苄非他明]] （U-0441） || 156-08-1 || [[C17H21N|{{chem2|C17H21N}}]] || [[File:Benzphetamine.svg|150px]]
|-
| U-0882 || 310-35-0 || [[C18H21NO2|{{chem2|C18H21NO2}}]] || [[File:U-0882.svg|150px]]
|-
| [[敌鼠]] （U-1363） || 82-66-6 || [[C23H16O3|{{chem2|C23H16O3}}]] || [[File:Diphenadione.svg|100px]]
|-
| [[羧雌醚]] （U-2911） || 1755-52-8 || [[C17H22O3|{{Chem2|C17H22O3}}]] || [[File:Carbestrol.svg|150px]]
|-
| [[U-4527]] || 66-81-9 || [[C15H23NO4|{{chem2|C15H23NO4}}]] || [[File:Cycloheximide.svg|150px]]
|-
| [[U-5956]] || 480-49-9 || [[C35H58O11|{{chem2|C35H58O11}}]] || [[File:FilipinIII.png|150px]]
|-
| [[U-6040]] || 76-43-7 || [[C20H29FO3|{{chem2|C20H29FO3}}]] || [[File:Fluoxymesterone.svg|150px]]
|-
| [[U-6056]] || 13117-35-6 || [[C13H18N2|{{chem2|C13H18N2}}]] || [[File:Dimethylhomotryptamine.svg|120px]]
|-
| [[U-8113]] || 1688-71-7 || [[C10H13NO|{{chem2|C10H13NO}}]] || [[File:U-8113.svg|150px]]
|-
| [[U-8344]] || 66-75-1 || [[C8H11Cl2N3O2|{{chem2|C8H11Cl2N3O2}}]] || [[File:Uramustine.svg|150px]]
|-
| [[U-8471]] || 2668-66-8 || [[C22H32O3|{{chem2|C22H32O3}}]] || [[File:Medrysone.svg|150px]]
|-
| [[U-8614]] || 426-13-1 || [[C22H29FO4|{{chem2|C22H29FO4}}]] || [[File:Fluorometholone.svg|150px]]
|-
| [[醋酸甲羥孕酮]] （U-8839） || 71-58-9 || [[C24H34O4|{{chem2|C24H34O4}}]] || [[File:Medroxyprogesterone acetate.svg|150px]]
|-
| [[U-8840]] || 520-85-4 || [[C22H32O3|{{chem2|C22H32O3}}]] || [[File:Medroxyprogesterone.svg|150px]]
|-
| [[2-氨基-1,1,3-三氰基-1-丙烯]] （U-9189） || 868-54-2 || [[C6H4N4|{{chem2|C6H4N4}}]] || [[File:Tricyanoaminopropene.svg|100px]]
|-
| [[U-9889]] || 18883-66-4 || [[C8H15N3O7|{{chem2|C8H15N3O7}}]] || [[File:Streptozocin.svg|150px]]
|}
===五位数===
{| class="wikitable sortable"
|-
! 名称 !! CAS号 !! 分子式 !! 化学结构
|-
| [[林可霉素]] （U-10149） || 154-21-2 || [[C18H34N2O6S|{{chem2|C18H34N2O6S}}]] || [[File:Lincomycin.png|150px]]
|-
| [[U-10157]] || 705-62-4 || [[C9H12N2S|{{chem2|C9H12N2S}}]] ||
|-
| [[米勃龙]] （U-10997）<ref name=Lyster/> || 3704-09-4 || [[C20H30O2|{{chem2|C20H30O2}}]] || [[File:Mibolerone structure.png|150px]]
|-
| [[U-11000A]] || 1845-11-0 || [[C29H31NO2|{{chem2|C29H31NO2}}]] || [[File:Nafoxidine.svg|150px]]
|-
| [[U-11555A]] || 64-96-0 || [[C28H31NO2|{{chem2|C28H31NO2}}]] || [[File:U-11,555 image.png|150px]]
|-
| [[曲托龙]] （U-11828）<ref name=Lyster>{{cite journal | vauthors=((Lyster, S. C.)), ((Duncan, G. W.)) | journal=Acta Endocrinologica | title=ANABOLIC, ANDROGENIC AND MYOTROPIC ACTIVITIES OF DERIVATIVES OF 7α-METHYL-19-NORTESTOSTERONE | volume=43 | issue=3 | pages=399–411 | date= July 1963 | url=https://academic.oup.com/ejendo/article/43/3/399/6955390 | doi=10.1530/acta.0.0430399}}</ref> || 3764-87-2 || [[C19H28O2|{{chem2|C19H28O2}}]] || [[File:Trestolone structure.svg|150px]]
|-
| [[U-12504]] || 1228-19-9 || [[C13H18ClN3O3S|{{chem2|C13H18ClN3O3S}}]] || [[File:Glypinamide.svg|150px]]
|-
| [[U-17312E]] || 2235-90-7 || [[C12H16N2|{{chem2|C12H16N2}}]] || [[File:AET.svg|150px]]
|-
| [[U-17323]] || 3801-06-7 || [[C24H31FO5|{{chem2|C24H31FO5}}]] || [[File:Fluorometholone acetate.svg|150px]]
|-
| [[U-17835]] || 1156-19-0 || [[C14H21N3O3S|{{chem2|C14H21N3O3S}}]] || [[File:Tolazamide.svg|150px]]
|-
| [[布洛芬]] （U-18573） || 15687-27-1 || [[C13H18O2|{{chem2|C13H18O2}}]] || [[File:Ibuprofen.svg|150px]]
|-
| [[勃拉睾酮]] （U-19763） || 1605-89-6 || [[C21H32O2|{{chem2|C21H32O2}}]] || [[File:Bolasterone.png|150px]]
|-
| {{lwd|Q27286852|吲哚克索}} （U-22020） || 5034-76-4 || [[C22H19NO2|{{chem2|C22H19NO2}}]] || [[File:Indoxole.svg|150px]]
|-
| [[PNU-22394]] (U-22394A) || 15923-78-1 || [[C13H16N2|{{chem2|C13H16N2}}]] || [[File:PNU-22394.svg|150px]]
|-
| U-22410A || 10090-61-6 || [[C28H29NO|{{chem2|C28H29NO}}]] || [[File:U-22,410A.svg|150px]]
|-
| [[卡鲁睾酮]] （U-22550） || 17021-26-0 || [[C21H32O2|{{chem2|C21H32O2}}]] || [[File:Calusterone.svg|150px]]
|-
| [[U-23284]] || 18771-50-1 || [[C9H16N2O6|{{chem2|C9H16N2O6}}]] || [[File:Tetrahydrouridine.svg|150px]]
|-
| U-23469<ref>{{cite journal | vauthors=((Castañer, J.)), ((Hillier, K.)) | journal=Drugs of the Future | title=U-23,469 | volume=5 | issue=11 | pages=564 | date= 1980 | url=http://journals.prous.com/journals/servlet/xmlxsl/pk_journals.xml_summary_pr?p_JournalId=2&p_RefId=1002363&p_IsPs=N | issn=0377-8282 | doi=10.1358/dof.1980.005.11.1002363}}</ref> || 36840-93-4 || [[C26H28O4|{{chem2|C26H28O4}}]] || [[File:U-23,469.svg|150px]]
|-
| U-24568 || 21766-17-6 || [[C26H22N2O2|{{chem2|C26H22N2O2}}]] || [[File:U-24,568.svg|150px]]
|-
| [[U-26597A]] || 8001-95-4 || [[C11H28ClN5O|{{chem2|C11H28ClN5O}}]] || [[File:Colestipol constituents.png|150px]]
|-
| [[U-28288D]] || 22195-34-2 || [[C10H19N3O2|{{chem2|C10H19N3O2}}]] || [[File:Guanadrel.svg|150px]]
|-
| {{le|2-MDP|2-MDP}} （U-23807A） || 33887-05-7 || [[C16H19NO|{{chem2|C16H19NO}}]] || [[File:2-MDP.svg|100px]]
|-
| [[U-28774]] || 27223-35-4 || [[C20H17ClN2O3|{{chem2|C20H17ClN2O3}}]] || [[File:Ketazolam.svg|150px]]
|-
| [[U-29409]] || 31785-60-1 || [[C18H14N2O|{{chem2|C18H14N2O}}]] || [[File:U-29409.svg|150px]]
|-
| [[U-30870]] || 50303-11-2 || [[C23H31NO2|{{chem2|C23H31NO2}}]] || [[File:U-30870.svg|150px]]
|-
| [[U-31355]] || 99983-92-3 || [[C11H10ClN3S|{{chem2|C11H10ClN3S}}]] || [[File:U-31,355.svg|150px]]
|-
| [[阿普唑仑]] （U-31889） || 28981-97-7 || [[C17H13ClN4|{{chem2|C17H13ClN4}}]] || [[File:Alprazolam structure.svg|150px]]
|-
| [[骨化二醇]] （U-32070） || 19356-17-3 || [[C27H44O2|{{chem2|C27H44O2}}]] || [[File:Calcidiol2.svg|150px]]
|-
| [[U-32802A]] || 36735-48-5 || [[C22H23F2NO|{{chem2|C22H23F2NO}}]] || [[File:U-32,802A.svg|150px]]
|-
| [[三唑仑]] （U-33030） || 28911-01-5 || [[C17H12Cl2N4|{{chem2|C17H12Cl2N4}}]] || [[File:Triazolam.svg|100px]]
|-
| U-35777A || 55199-71-8 || [[C23H27F2NO2|{{chem2|C23H27F2NO2}}]] || [[File:U-35,777A.svg|150px]]
|-
| [[U-37883A]] || 57568-80-6 || [[C21H35N3O|{{chem2|C21H35N3O}}]] || [[File:U-37883A.svg|150px]]
|-
| [[U-41792]] || 56714-70-6 || [[C21H29NO|{{chem2|C21H29NO}}]] || [[File:U-41792.svg|150px]]
|-
| [[U-42585]] || 53882-12-5 || [[C11H6ClN3O6|{{chem2|C11H6ClN3O6}}]] || [[File:Lodoxamide.svg|150px]]
|-
| [[U-46619]] || 56985-40-1 || [[C21H34O4|{{chem2|C21H34O4}}]] || [[File:U-46619.svg|150px]]
|-
| [[U-46785]] || 61263-35-2 || [[C23H38O4|{{chem2|C23H38O4}}]] || [[File:Meteneprost.svg|150px]]
|-
| [[U-47109]] || 67579-13-9 || [[C15H20Cl2N2O|{{chem2|C15H20Cl2N2O}}]] || [[File:U-47109 structure.png|150px]]
|-
| [[U-47476A]] || 36192-18-4 || [[C12H18N2|{{chem2|C12H18N2}}]] || [[File:U-47,476A.svg|150px]]
|-
| [[U-47700]] || 82657-23-6 || [[C16H22Cl2N2O|{{chem2|C16H22Cl2N2O}}]] || [[File:U-47700 fixedstructure.svg|150px]]
|-
| [[溴朵林]] （U-47931E） || 67579-24-2 || [[C15H21BrN2O|C15H21BrN2O]] || [[File:U-47931E structure.png|150px]]
|-
| [[U-48520]] || 67579-11-7 || [[C16H23ClN2O|{{chem2|C16H23ClN2O}}]] || [[File:U-48520 structure.png|150px]]
|-
| [[依氯那明]] （U-48753） || 67450-44-6 || [[C16H22Cl2N2O|{{chem2|C16H22Cl2N2O}}]] || [[File:Eclanamine.svg|150px]]
|-
| [[U-48800]] || 2370977-17-4 || [[C17H24Cl2N2O|{{chem2|C17H24Cl2N2O}}]] || [[File:U-48800 structure.png|150px]]
|-
| [[U-49900]] || 67579-76-4 || [[C18H26Cl2N2O|{{chem2|C18H26Cl2N2O}}]] || [[File:U-49900 structure.png|150px]]
|-
| [[U-50211]] || 98587-47-4 || [[C16H24N2O2|{{chem2|C16H24N2O2}}]] || [[File:U-50211 structure.png|150px]]
|-
| [[U-50488]] || 67198-13-4 || [[C19H26Cl2N2O|{{chem2|C19H26Cl2N2O}}]] || [[File:U-50488 structure.svg|150px]]
|-
| [[U-51574]] || PubChem CID：44269303 || [[C17H24Cl2N2O|{{chem2|C17H24Cl2N2O}}]] || [[File:U-51574 structure.png|150px]]
|-
| [[U-52047]] || 71628-96-1 || [[C28H31NO10|{{Chem2|C28H31NO10}}]] || [[File:Menogaril.png|150px]]
|-
| [[U-53059]] || 70529-35-0 || [[C18H14F3NO2S|{{chem2|C18H14F3NO2S}}]] || [[File:Itazigrel.svg|150px]]
|-
| [[U-54669F]] || 72141-57-2 || [[C27H22F4N4O3S|{{chem2|C27H22F4N4O3S}}]] || [[File:Losulazine.svg|150px]]
|-
| [[U-57700]] || 102092-12-6 || [[C16H21N|{{chem2|C16H21N}}]] || [[File:(Z)-Tazadolene.svg|150px]]
|-
| [[U-57930E]] || 79548-73-5 || [[C17H31ClN2O5S|{{chem2|C17H31ClN2O5S}}]] || [[File:Pirlimycin structure.svg|150px]]
|-
| [[U-58838]] || 83701-22-8 || [[C9H15N5O4S|{{chem2|C9H15N5O4S}}]] || [[File:Minoxidil_sulfate.svg|100px]]
|-
| {{WikidataLink|Q27287941}} （U-60257） || 79672-88-1 || [[C26H35NO4|{{chem2|C26H35NO4}}]] || [[File:Piriprost.svg|150px]]
|-
| [[U-61431F]] || 81845-44-5 || [[C22H36O4|{{chem2|C22H36O4}}]] || [[File:Ciprostene.svg|150px]]
|-
| {{le|螺朵林|Spiradoline}} （U-62066） || 87151-85-7 || [[C22H30Cl2N2O2|{{chem2|C22H30Cl2N2O2}}]] || [[File:Spiradoline Structure.svg|150px]]
|-
| [[U-63557A]] || 85666-24-6 || [[C15H11NO3|{{chem2|C15H11NO3}}]] || [[File:Furegrelate.svg|150px]]
|-
| [[U-64279E]] || 104010-37-9 || [[C19H17N5O7S3|{{chem2|C19H17N5O7S3}}]] || [[File:Ceftiofur.png|150px]]
|-
| [[阿仑替莫]] （U-66444B） || 112892-81-6 || [[C19H25NO|{{chem2|C19H25NO}}]] || [[File:Alentemol.svg|100px]]
|-
| [[U-69167]] || 99499-40-8 || [[C16H17N3OS2|{{chem2|C16H17N3OS2}}]] || [[File:Disuprazole.svg|150px]]
|-
| [[U-69593]] || 96744-75-1 || [[C22H32N2O2|{{chem2|C22H32N2O2}}]] || [[File:U-69,593 structure.svg|150px]]
|-
| [[U-73122]] || 112648-68-7 || [[C29H40N2O3|{{chem2|C29H40N2O3}}]] || [[File:U-73122.svg|150px]]
|-
| [[U-73343]] || 142878-12-4 || [[C29H42N2O3|{{chem2|C29H42N2O3}}]] || [[File:U-73343.svg|150px]]
|-
| [[U-74006]] || 110101-66-1 || [[C38H52N6O2|{{chem2|C38H52N6O2}}]] || [[File:Tirilazad.svg|150px]]
|-
| {{lwd|Q27089045|U-75302}} || 119477-85-9 || [[C22H33NO3|{{chem2|C22H33NO3}}]] ||
|-
| [[U-75875]] （Pnu-75875） || 112190-24-6 || [[C45H61N7O7|{{chem2|C45H61N7O7}}]] || [[File:U-75875.svg|150px]]
|-
| [[U-77891]] || 119878-31-8 || [[C18H24Br2N2O|{{chem2|C18H24Br2N2O}}]] || [[File:U-77891.svg|150px]]
|-
| [[U-78036]] || 123742-98-3 || [[C17H11ClN2O|{{chem2|C17H11ClN2O}}]] || [[File:U-78036.svg|150px]]
|-
| [[U-78875]] || 124423-84-3 || [[C18H17N5O2|{{chem2|C18H17N5O2}}]] || [[File:Panadiplon.svg|100px]]
|-
| {{lwd|Q27263977}} （U-80244） || 119813-10-4 || [[C41H37ClN6O5|{{chem2|C41H37ClN6O5}}]] || [[File:Carzelesin.svg|150px]]
|-
| [[U-80493]] || 136816-67-6 || [[C21H30N4O|{{chem2|C21H30N4O}}]] || [[File:U-80493.svg|150px]]
|-
| U-81749 || 126103-94-4 || [[C33H56N4O4|{{chem2|C33H56N4O4}}]] || [[File:U-81749.svg|150px]]
|-
| [[U-82208E]] || 136591-56-5 || [[C20H36N2O3S|{{chem2|C20H36N2O3S}}]] ||
|-
| [[U-82209E]] || 136591-58-7 || [[C20H36N2O3S|{{chem2|C20H36N2O3S}}]] ||
|-
| [[U-84569]] || 130736-25-3 || [[C25H23NO4|{{chem2|C25H23NO4}}]] || [[File:U-84569.svg|150px]]
|-
| [[U-86983]] || 130736-65-1 || [[C19H18N2O4|{{chem2|C19H18N2O4}}]] || [[File:U-86983.svg|150px]]
|-
| [[阿替韦啶]] （U-87201E） || 138540-32-6 || [[C21H25N5O2|{{chem2|C21H25N5O2}}]] || [[File:Atevirdine structure.svg|150px]]
|-
| [[U-88779E]] || 149539-01-5 || [[C29H33ClN2O2|{{chem2|C29H33ClN2O2}}]] || [[File:U-88779E.svg|150px]]
|-
| [[U88999E]] || 142223-57-2 || [[C29H32F2N2O2|{{chem2|C29H32F2N2O2}}]] || [[File:U88999E.svg|150px]]
|-
| U-89360E || 161897-65-0 || [[C28H52N8O6|{{chem2|C28H52N8O6}}]] || [[File:U-89360E.svg|150px]]
|-
| [[U-90152]] || 136817-59-9 || [[C22H28N6O3S |{{chem2|C22H28N6O3S}}]] || [[File:Delavirdine.svg|150px]]
|-
| [[PNU-91356A]] （U-91356） || 152886-85-6 || [[C13H17N3O|{{chem2|C13H17N3O}}]] || [[File:PNU91356A structure.png|150px]]
|-
| [[U-92032]] || 142223-92-5 || [[C30H35F2N3O2|{{chem2|C30H35F2N3O2}}]] || [[File:U-92032.svg|150px]]
|-
| [[U-92798]] || PC9891838 || [[C30H34F2N2O2|{{chem2|C30H34F2N2O2}}]] || [[File:U92798.svg|150px]]
|-
| [[U-96988]] || 149394-65-0 || [[C24H26O3|{{chem2|C24H26O3}}]] || [[File:U-96988.svg|150px]]
|-
| [[普拉克索]] （U-98528E） || 104632-26-0 || [[C10H17N3S|{{chem2|C10H17N3S}}]] || [[File:Pramipexole.svg|150px]]
|-
| {{le|JPC-211|PNU-99,194}} （U-99194） || 82668-33-5 || [[C17H27NO2|{{chem2|C17H27NO2}}]] || [[File:PNU-99194A-structure.png|150px]]
|-
| U-99363 || 179556-82-2 || [[C20H27N3O|{{chem2|C20H27N3O}}]] || [[File:U-99363.svg|150px]]
|}

===六位数===
{| class="wikitable sortable"
|-
! 名称 !! CAS号 !! 分子式 !! 化学结构
|-
| [[U-100480]] || 168828-58-8 || [[C16H20FN3O3S|{{chem2|C16H20FN3O3S}}]] || [[File:Sutezolid structure.svg|150px]]
|-
| [[U-101387]] || 170858-33-0 || [[C21H27N3O3S|{{chem2|C21H27N3O3S}}]] || [[File:Sonepiprazole.svg|150px]]
|-
| [[U-101958]] || 170856-57-2 || [[C21H29N3O|{{chem2|C21H29N3O}}]] || [[File:U-101958.svg|150px]]
|-
|[[U-103017]] || 166335-18-8 || [[C28H28N2O5S|{{chem2|C28H28N2O5S}}]] || [[File:Pnu-103017.svg|150px]]
|}

==参考文献==
{{reflist}}

==外部链接==
* [http://www.upjohn.net Memories of The Upjohn Company]
* {{usurped|1=[https://archive.today/20130129064121/http://www.michmarkers.com/startup.asp?startpage=S0582.htm Upjohn first company location historical marker]}}

{{Authority control}}

[[Category:1995年併購]]
[[Category:辉瑞]]
[[Category:生命科学产业]]

Upjohn - 版本历史

imported>Htmlzycq：​/* 五位数 */

imported>Htmlzycq：/* 五位数 */