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URB754 - 版本历史
2026-07-18T23:43:20Z
本wiki上该页面的版本历史
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imported>InternetArchiveBot：补救2个来源，并将0个来源标记为失效。) #IABot (v2.0.9.5) (KCUSCBZMOGYNMYBGBBFRQQIZCGYNKGOC - 28908
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<p>补救2个来源，并将0个来源标记为失效。) #IABot (v2.0.9.5) (<a href="/index.php?title=User:KCUSCBZMOGYNMYBGBBFRQQIZCGYNKGOC&action=edit&redlink=1" class="new" title="User:KCUSCBZMOGYNMYBGBBFRQQIZCGYNKGOC（页面不存在）">KCUSCBZMOGYNMYBGBBFRQQIZCGYNKGOC</a> - 28908</p>
<p><b>新页面</b></p><div>{{chembox<br />
| Verifiedfields = changed<br />
| Watchedfields = changed<br />
| verifiedrevid = 425028581<br />
| Name = URB754<br />
| ImageFile = URB754.svg<br />
| ImageClass = skin-invert-image<br />
| PIN = 6-Methyl-2-(4-methylanilino)-4''H''-3,1-benzoxazin-4-one<br />
| SystematicName = <br />
| OtherNames = <br />
|Section1={{Chembox Identifiers<br />
| Abbreviations = <br />
| CASNo_Ref = {{cascite|correct|??}}<br />
| CASNo = 86672-58-4<br />
| UNII_Ref = {{fdacite|correct|FDA}}<br />
| UNII = 7672NBP7ZF<br />
| EINECS = <br />
| PubChem = 848487<br />
| SMILES = CC1=CC=C(C=C1)NC2=NC3=C(C=C(C=C3)C)C(=O)O2<br />
| ChemSpiderID_Ref = {{chemspidercite|changed|chemspider}}<br />
| ChemSpiderID = 741376<br />
| InChI = 1/C16H14N2O2/c1-10-3-6-12(7-4-10)17-16-18-14-8-5-11(2)9-13(14)15(19)20-16/h3-9H,1-2H3,(H,17,18)<br />
| InChIKey = GFWNGVKCDGYFKG-UHFFFAOYAI<br />
| StdInChI_Ref = {{stdinchicite|changed|chemspider}}<br />
| StdInChI = 1S/C16H14N2O2/c1-10-3-6-12(7-4-10)17-16-18-14-8-5-11(2)9-13(14)15(19)20-16/h3-9H,1-2H3,(H,17,18)<br />
| StdInChIKey_Ref = {{stdinchicite|changed|chemspider}}<br />
| StdInChIKey = GFWNGVKCDGYFKG-UHFFFAOYSA-N<br />
| RTECS = <br />
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| ChEBI_Ref = {{ebicite|correct|EBI}}<br />
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| KEGG_Ref = {{keggcite|correct|kegg}}<br />
| KEGG =<br />
}}<br />
|Section2={{Chembox Properties<br />
| C=16 | H=14 | N=2 | O=2<br />
| Appearance = <br />
| Density = <br />
| MeltingPt = <br />
| MeltingPt_notes = <br />
| BoilingPt = <br />
| BoilingPt_notes = <br />
| Solubility = <br />
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| LogP = <br />
| VaporPressure = <br />
| HenryConstant = <br />
| AtmosphericOHRateConstant = <br />
| pKa = <br />
| pKb = }}<br />
|Section6={{Chembox Pharmacology<br />
| ATCCode_prefix = <br />
| ATCCode_suffix = <br />
| ATC_Supplemental =<br />
| AdminRoutes = <br />
| Bioavail = <br />
| Metabolism = <br />
| HalfLife = <br />
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| Excretion = <br />
| Legal_status = <br />
| Legal_US = <br />
| Legal_UK = <br />
| Legal_AU = <br />
| Legal_CA = <br />
| Pregnancy_category = <br />
| Pregnancy_AU = <br />
| Pregnancy_US = }}<br />
|Section7={{Chembox Hazards<br />
| ExternalSDS = <br />
| MainHazards = <br />
| NFPA-H = <br />
| NFPA-F = <br />
| NFPA-R = <br />
| NFPA-S = <br />
| HPhrases = <br />
| PPhrases = <br />
| GHS_ref = <br />
| FlashPt = <br />
| AutoignitionPt = <br />
| ExploLimits = <br />
| LD50 =<br />
| PEL = }}<br />
|Section8={{Chembox Related<br />
| OtherAnions = <br />
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| OtherCompounds = }}<br />
}}<br />
'''{{PAGENAME}}'''是一种[[氮化合物|含氮]]有机化合物，分子式[[C16H14N2O2|{{chem2|C16H14N2O2}}]]，曾被报道能用作{{le|单酰甘油脂肪酶|Monoacylglycerol lipase}}（MAGL）的[[酶抑制剂|非竞争性抑制剂]]<ref name="pmid16116451">{{cite journal |vauthors=Makara JK, Mor M, Fegley D, Szabó SI, Kathuria S, Astarita G, Duranti A, Tontini A, Tarzia G, Rivara S, Freund TF, Piomelli D |title=Selective inhibition of 2-AG hydrolysis enhances endocannabinoid signaling in hippocampus |journal=Nat. Neurosci. |volume=8 |issue=9 |pages=1139–41 |year=2005 |pmid=16116451 |doi=10.1038/nn1521 |s2cid=52810445 |url=https://escholarship.org/uc/item/085499pd |access-date=2026-03-10 |archive-date=2021-08-23 |archive-url=https://web.archive.org/web/20210823141950/https://escholarship.org/uc/item/085499pd |dead-url=no }}</ref>，但后续的研究发现其抑制功能其实是由样品中的杂质引起的<ref>{{cite journal| doi = 10.1002/adic.200790073| pmid = 17970304| title = Identification of a Bioactive Impurity in a Commercial Sample of 6-Methyl-2-p-Tolylaminobenzo[d][1,3]Oxazin-4-One (URB754)| journal = Annali di Chimica| volume = 97| issue = 9| pages = 887–94| year = 2007| last1 = Tarzia| first1 = Giorgio| last2 = Antonietti| first2 = Francesca| last3 = Duranti| first3 = Andrea| last4 = Tontini| first4 = Andrea| last5 = Mor| first5 = Marco| last6 = Rivara| first6 = Silvia| last7 = Traldi| first7 = Pietro| last8 = Astarita| first8 = Giuseppe| last9 = King| first9 = Alvin| last10 = Clapper| first10 = Jason R.| last11 = Piomelli| first11 = Daniele| url = https://escholarship.org/uc/item/2133f3k0| url-access = subscription| access-date = 2026-03-10| archive-date = 2024-11-03| archive-url = https://web.archive.org/web/20241103152937/https://escholarship.org/uc/item/2133f3k0| dead-url = no}}</ref>。<br />
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==参考文献==<br />
{{reflist}}<br />
<br />
[[Category:苯并𫫇嗪]]<br />
[[Category:内酯]]<br />
[[Category:苯胺]]</div>
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