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2026-02-08T11:14:35Z

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'''短瞬態受體電位通道 5''' ('''Short transient receptor potential channel 5,''' '''TrpC5''' ) 又稱'''瞬態受體蛋白 5''' ( '''TRP-5''' ) ，化学式为：C5111H7968O1513N1344S49<ref>{{Cite web |title=Expasy - ProtParam |url=https://web.expasy.org/cgi-bin/protparam/protparam_bis.cgi?Q9UL62@1-973@ |website=web.expasy.org |access-date=2026-02-08}}</ref>，是一種在人類中由''TRPC5''[[基因]]編碼的[[離子通道]]蛋白。 <ref name="entrez">{{Cite web|title=Entrez Gene: transient receptor potential cation channel|url=https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7224}}</ref> <ref name="pmid10493832">{{Cite journal |vauthors=Sossey-Alaoui K, Lyon JA, Jones L, Abidi FE, Hartung AJ, Hane B, Schwartz CE, Stevenson RE, Srivastava AK |date=September 1999 |title=Molecular cloning and characterization of TRPC5 (HTRP5), the human homologue of a mouse brain receptor-activated capacitative Ca2+ entry channel |journal=Genomics |volume=60 |issue=3 |page=330–40 |doi=10.1006/geno.1999.5924 |pmid=10493832}}</ref> <ref name="pmid16382100">{{Cite journal |vauthors=Clapham DE, Julius D, Montell C, Schultz G |date=December 2005 |title=International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels |journal=Pharmacol. Rev. |volume=57 |issue=4 |page=427–50 |doi=10.1124/pr.57.4.6 |pmid=16382100 |s2cid=17936350}}</ref> TrpC5 是[[哺乳动物|哺乳動物]]{{link-en|Transient receptor potential channel||瞬態受體電位離子通道}}{{link-en|TRPC||TRPC家族}}的亞型。

== 功能 ==
TrpC5 是七種[[哺乳動物]]TRPC （transient receptor potential canonical）蛋白中的一種。 TrpC5 是一種多次穿膜的膜蛋白，且被認為構成了受體活化型的非選擇性鈣離子通道。其單獨存在時即具有活性，但也能與TRPC1 、 TRPC3和TRPC4組成異質多聚體。此外，其也和多種蛋白質相互作用，包括[[钙调蛋白|鈣調蛋白(CaM)]]、 {{link-en|CABP1||CABP1}} 、 {{link-en|enkurin||enkurin}} 、Na +–H +交換調節因子 ( NHERF )、干擾素誘導的 GTP 結合蛋白 ( MX1 )、{{link-en|RNF24||RNF24}} 、{{link-en|SEC14||SEC14}}結構域和血影蛋白重複序列蛋白 1 ( {{link-en|SESTD1||SESTD1}} )。 <ref name="entrez">{{Cite web|title=Entrez Gene: transient receptor potential cation channel|url=https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7224}}<cite class="citation web cs1" data-ve-ignore="true">[https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7224 "Entrez Gene: transient receptor potential cation channel"].</cite></ref>

TRPC4 和 TRPC5 與汞毒性<ref>{{Cite journal |vauthors=Xu SZ, Zeng B, Daskoulidou N, Chen GL, Atkin SL, Lukhele B |date=January 2012 |title=Activation of TRPC cationic channels by mercurial compounds confers the cytotoxicity of mercury exposure |journal=Toxicol. Sci. |volume=125 |issue=1 |page=56–68 |doi=10.1093/toxsci/kfr268 |pmid=21984481 |doi-access=free}}</ref>和神經行為有關。 <ref>{{Cite journal |vauthors=Riccio A, Li Y, Moon J, Kim KS, Smith KS, Rudolph U, Gapon S, Yao GL, Tsvetkov E, Rodig SJ, Van't Veer A, Meloni EG, Carlezon WA, Bolshakov VY, Clapham DE |date=May 15, 2009 |title=Essential role for TRPC5 in amygdala function and fear-related behavior |journal=Cell |volume=137 |issue=4 |page=761–72 |doi=10.1016/j.cell.2009.03.039 |pmc=2719954 |pmid=19450521}}</ref> TRPC5於2021年被發現是牙齒冷感覺系统的組成部分。 <ref>{{Cite journal |last=Bernal |first=Laura |last2=Sotelo-Hitschfeld |first2=Pamela |last3=König |first3=Christine |last4=Sinica |first4=Viktor |last5=Wyatt |first5=Amanda |last6=Winter |first6=Zoltan |last7=Hein |first7=Alexander |last8=Touska |first8=Filip |last9=Reinhardt |first9=Susanne |last10=Tragl |first10=Aaron |last11=Kusuda |first11=Ricardo |year=2021 |title=Odontoblast TRPC5 channels signal cold pain in teeth |journal=Science Advances |volume=7 |issue=13 |page=eabf5567 |doi=10.1126/sciadv.abf5567 |pmc=7997515 |pmid=33771873 |laysource=Freichel}}</ref>
其還被發現参與如[[氯仿]]、[[氟烷]]和[[异丙酚|異丙酚]]等麻醉劑的作用。 <ref name="pmid18204473">{{Cite journal |vauthors=Bahnasi YM, Wright HM, Milligan CJ, Dedman AM, Zeng F, Hopkins PM, Bateson AN, Beech DJ |date=April 2008 |title=Modulation of TRPC5 cation channels by halothane, chloroform and propofol |journal=Br. J. Pharmacol. |volume=153 |issue=7 |page=1505–12 |doi=10.1038/sj.bjp.0707689 |pmc=2437913 |pmid=18204473}}</ref>

== 活化 ==
同源多聚體 TRPC5 和異源多聚體 TRPC5- TRPC1通道被細胞外的{{link-en|thioredoxase||硫氧還蛋白}}活化。 <ref name="pmid18172497">{{Cite journal |vauthors=Xu SZ, Sukumar P, Zeng F, Li J, Jairaman A, English A, Naylor J, Ciurtin C, Majeed Y, Milligan CJ, Bahnasi YM, Al-Shawaf E, Porter KE, Jiang LH, Emery P, Sivaprasadarao A, Beech DJ |date=January 2008 |title=TRPC channel activation by extracellular thioredoxin |url=https://archive.org/details/sim_nature-uk_2008-01-03_451_7174/page/68 |journal=Nature |volume=451 |issue=7174 |page=69–72 |doi=10.1038/nature06414 |pmc=2645077 |pmid=18172497}}</ref>

== 交互作用 ==
TRPC5 已被證明與STMN3 、 <ref name="pmid12858178">{{Cite journal |vauthors=Greka A, Navarro B, Oancea E, Duggan A, Clapham DE |date=August 2003 |title=TRPC5 is a regulator of hippocampal neurite length and growth cone morphology |journal=Nat. Neurosci. |volume=6 |issue=8 |page=837–45 |doi=10.1038/nn1092 |pmid=12858178 |s2cid=7523946}}</ref> TRPC1 、 <ref name="pmid12857742">{{Cite journal |vauthors=Strübing C, Krapivinsky G, Krapivinsky L, Clapham DE |date=October 2003 |title=Formation of novel TRPC channels by complex subunit interactions in embryonic brain |url=https://archive.org/details/sim_journal-of-biological-chemistry_2003-10-03_278_40/page/39014 |journal=J. Biol. Chem. |volume=278 |issue=40 |page=39014–9 |doi=10.1074/jbc.M306705200 |pmid=12857742 |doi-access=free}}</ref> <ref name="pmid12032305">{{Cite journal |vauthors=Hofmann T, Schaefer M, Schultz G, Gudermann T |date=May 2002 |title=Subunit composition of mammalian transient receptor potential channels in living cells |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue=11 |page=7461–6 |doi=10.1073/pnas.102596199 |pmc=124253 |pmid=12032305 |doi-access=free}}</ref>和TRPC4間有[[蛋白質交互作用|交互作用]]。 <ref name="pmid12032305" />

== 參見 ==
* {{link-en|TRP通道|transient receptor potential channel|TRP通道}}
* {{link-en|TRPC||TRPC}}

== 參考資料 ==
{{Reflist|35em}}

== 延伸閱讀 ==
{{refbegin|35em}}
* {{Cite book|vauthors=Beech DJ|title=Transient Receptor Potential (TRP) Channels|chapter=Canonical transient receptor potential 5|journal=Handb Exp Pharmacol|volume=179|issue=179|pages=109–23|year=2007|pmid=17217053|doi=10.1007/978-3-540-34891-7_6|isbn=978-3-540-34889-4|series=Handbook of Experimental Pharmacology}}
* {{cite journal |vauthors=Beech DJ |year=2007 |title=Bipolar phospholipid sensing by TRPC5 calcium channel |journal=Biochem. Soc. Trans. |volume=35 |issue=Pt 1 |pages=101–4 |doi=10.1042/BST0350101 |pmid=17233612}}
{{refend}}

== 外部連接 ==

* {{MeshName|TRPC5+protein,+human}}
[[Category:离子通道]]
[[Category:位於人類X染色體的基因]]

TRPC5 - 版本历史

imported>曦城星月 来自 2026年2月8日 (日) 11:14

imported>曦城星月来自 2026年2月8日 (日) 11:14