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{{Infobox_gene}}
'''{{PAGENAME}}'''是人类[[基因]] ''{{PAGENAME}}'' 编码的[[蛋白质]]，属于一种[[TNF受体相关因子]]（TRAF）。

== 蛋白质的相互作用 ==
TRAF6蛋白与下列[[蛋白質交互作用|蛋白質进行互作]]：
{{div col|colwidth=20em}}
* [[ASK1]]<ref name = pmid9774977>{{cite journal | vauthors = Nishitoh H, Saitoh M, Mochida Y, Takeda K, Nakano H, Rothe M, Miyazono K, Ichijo H | title = ASK1 is essential for JNK/SAPK activation by TRAF2 | journal = Mol. Cell | volume = 2 | issue = 3 | pages = 389–95 | date = September 1998 | pmid = 9774977 | doi = 10.1016/s1097-2765(00)80283-x| doi-access = free }}</ref><ref name = pmid10523862>{{cite journal | vauthors = Hoeflich KP, Yeh WC, Yao Z, Mak TW, Woodgett JR | title = Mediation of TNF receptor-associated factor effector functions by apoptosis signal-regulating kinase-1 (ASK1) | journal = Oncogene | volume = 18 | issue = 42 | pages = 5814–20 | date = October 1999 | pmid = 10523862 | doi = 10.1038/sj.onc.1202975 | s2cid = 12132452 | doi-access = }}</ref><ref name = pmid10921914>{{cite journal | vauthors = Mochida Y, Takeda K, Saitoh M, Nishitoh H, Amagasa T, Ninomiya-Tsuji J, Matsumoto K, Ichijo H | title = ASK1 inhibits interleukin-1-induced NF-kappa B activity through disruption of TRAF6-TAK1 interaction | url = https://archive.org/details/sim_journal-of-biological-chemistry_2000-10-20_275_42/page/32746 | journal = J. Biol. Chem. | volume = 275 | issue = 42 | pages = 32747–52 | date = October 2000 | pmid = 10921914 | doi = 10.1074/jbc.M003042200 | doi-access = free }}</ref>
* [[CD40]]<ref name = pmid9990007>{{cite journal | vauthors = Tsukamoto N, Kobayashi N, Azuma S, Yamamoto T, Inoue J | title = Two differently regulated nuclear factor kappaB activation pathways triggered by the cytoplasmic tail of CD40 | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 96 | issue = 4 | pages = 1234–9 | date = February 1999 | pmid = 9990007 | pmc = 15446 | doi = 10.1073/pnas.96.4.1234| bibcode = 1999PNAS...96.1234T | doi-access = free }}</ref><ref name = pmid9384571>{{cite journal | vauthors = Roy N, Deveraux QL, Takahashi R, Salvesen GS, Reed JC | title = The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases | url = https://archive.org/details/sim_embo-journal_1997-12-01_16_23/page/6914 | journal = EMBO J. | volume = 16 | issue = 23 | pages = 6914–25 | date = Dec 1997 | pmid = 9384571 | pmc = 1170295 | doi = 10.1093/emboj/16.23.6914 }}</ref>
* [[FHL2]]<ref name = pmid18768464>{{cite journal | vauthors = Bai S, Zha J, Zhao H, Ross FP, Teitelbaum SL | title = Tumor necrosis factor receptor-associated factor 6 is an intranuclear transcriptional coactivator in osteoclasts | url = https://archive.org/details/sim_journal-of-biological-chemistry_2008-11-07_283_45/page/30860 | journal = J. Biol. Chem. | volume = 283 | issue = 45 | pages = 30861–7 | date = November 2008 | pmid = 18768464 | pmc = 2662164 | doi = 10.1074/jbc.M802525200 | doi-access = free }}</ref>
* [[HSPB2]]<ref name = pmid18950704>{{cite journal | vauthors = Wu Y, Liu J, Zhang Z, Huang H, Shen J, Zhang S, Jiang Y, Luo L, Yin Z | title = HSP27 regulates IL-1 stimulated IKK activation through interacting with TRAF6 and affecting its ubiquitination | journal = Cell. Signal. | volume = 21 | issue = 1 | pages = 143–50 | date = January 2009 | pmid = 18950704 | doi = 10.1016/j.cellsig.2008.10.001 }}</ref>
* [[IKBKG]]<ref name = pmid18180283/><ref name = pmid18617513>{{cite journal | vauthors = Lamothe B, Campos AD, Webster WK, Gopinathan A, Hur L, Darnay BG | title = The RING domain and first zinc finger of TRAF6 coordinate signaling by interleukin-1, lipopolysaccharide, and RANKL | url = https://archive.org/details/sim_journal-of-biological-chemistry_2008-09-05_283_36/page/24870 | journal = J. Biol. Chem. | volume = 283 | issue = 36 | pages = 24871–80 | date = September 2008 | pmid = 18617513 | pmc = 2529010 | doi = 10.1074/jbc.M802749200 | doi-access = free }}</ref>
* [[IRAK1]]<ref name = pmid18234474/><ref name = pmid10383454/><ref name = pmid9374458/><ref name = pmid11518704>{{cite journal | vauthors = Qian Y, Commane M, Ninomiya-Tsuji J, Matsumoto K, Li X | title = IRAK-mediated translocation of TRAF6 and TAB2 in the interleukin-1-induced activation of NFkappa B | journal = J. Biol. Chem. | volume = 276 | issue = 45 | pages = 41661–7 | date = November 2001 | pmid = 11518704 | doi = 10.1074/jbc.M102262200 | doi-access = free }}</ref><ref name = pmid8837778>{{cite journal | vauthors = Cao Z, Xiong J, Takeuchi M, Kurama T, Goeddel DV | title = TRAF6 is a signal transducer for interleukin-1 | url = https://archive.org/details/sim_nature-uk_1996-10-03_383_6599/page/442 | journal = Nature | volume = 383 | issue = 6599 | pages = 443–6 | date = October 1996 | pmid = 8837778 | doi = 10.1038/383443a0 | bibcode = 1996Natur.383..443C | s2cid = 4269027 }}</ref><ref name = pmid12566447>{{cite journal | vauthors = Takatsuna H, Kato H, Gohda J, Akiyama T, Moriya A, Okamoto Y, Yamagata Y, Otsuka M, Umezawa K, Semba K, Inoue J | title = Identification of TIFA as an adapter protein that links tumor necrosis factor receptor-associated factor 6 (TRAF6) to interleukin-1 (IL-1) receptor-associated kinase-1 (IRAK-1) in IL-1 receptor signaling | url = https://archive.org/details/sim_journal-of-biological-chemistry_2003-04-04_278_14/page/12144 | journal = J. Biol. Chem. | volume = 278 | issue = 14 | pages = 12144–50 | date = April 2003 | pmid = 12566447 | doi = 10.1074/jbc.M300720200 | doi-access = free }}</ref><ref name = pmid11960013>{{cite journal | vauthors = Li S, Strelow A, Fontana EJ, Wesche H | title = IRAK-4: a novel member of the IRAK family with the properties of an IRAK-kinase | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 99 | issue = 8 | pages = 5567–72 | date = April 2002 | pmid = 11960013 | pmc = 122810 | doi = 10.1073/pnas.082100399 | bibcode = 2002PNAS...99.5567L | doi-access = free }}</ref><ref name = pmid10920205>{{cite journal | vauthors = Ling L, Goeddel DV | title = T6BP, a TRAF6-interacting protein involved in IL-1 signaling | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 97 | issue = 17 | pages = 9567–72 | date = August 2000 | pmid = 10920205 | pmc = 16905 | doi = 10.1073/pnas.170279097 | doi-access = free | bibcode = 2000PNAS...97.9567L }}</ref><ref name = pmid11259596>{{cite journal | vauthors = Takaesu G, Ninomiya-Tsuji J, Kishida S, Li X, Stark GR, Matsumoto K | title = Interleukin-1 (IL-1) receptor-associated kinase leads to activation of TAK1 by inducing TAB2 translocation in the IL-1 signaling pathway | url = https://archive.org/details/sim_molecular-and-cellular-biology_2001-04_21_7/page/2474 | journal = Mol. Cell. Biol. | volume = 21 | issue = 7 | pages = 2475–84 | date = April 2001 | pmid = 11259596 | pmc = 86880 | doi = 10.1128/MCB.21.7.2475-2484.2001 }}</ref>
* [[IRAK2]]<ref name = pmid10383454>{{cite journal | vauthors = Wesche H, Gao X, Li X, Kirschning CJ, Stark GR, Cao Z | title = IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) family | url = https://archive.org/details/sim_journal-of-biological-chemistry_1999-07-02_274_27/page/19402 | journal = J. Biol. Chem. | volume = 274 | issue = 27 | pages = 19403–10 | date = July 1999 | pmid = 10383454 | doi = 10.1074/jbc.274.27.19403| doi-access = free }}</ref><ref name = pmid9374458>{{cite journal | vauthors = Muzio M, Ni J, Feng P, Dixit VM | title = IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling | url = https://archive.org/details/sim_science_1997-11-28_278_5343/page/1612 | journal = Science | volume = 278 | issue = 5343 | pages = 1612–5 | date = November 1997 | pmid = 9374458 | doi = 10.1126/science.278.5343.1612| bibcode = 1997Sci...278.1612M }}</ref>
* [[TAB1]]<ref name = pmid10882101/><ref name = pmid19112497/><ref name = pmid10094049>{{cite journal | vauthors = Ninomiya-Tsuji J, Kishimoto K, Hiyama A, Inoue J, Cao Z, Matsumoto K | title = The kinase TAK1 can activate the NIK-I kappaB as well as the MAP kinase cascade in the IL-1 signalling pathway | url = https://archive.org/details/sim_nature-uk_1999-03-18_398_6724/page/252 | journal = Nature | volume = 398 | issue = 6724 | pages = 252–6 | date = March 1999 | pmid = 10094049 | doi = 10.1038/18465 | bibcode = 1999Natur.398..252N | s2cid = 4421236 }}</ref>
* [[MAP3K7IP2]]<ref name = pmid18180283>{{cite journal | vauthors = Windheim M, Stafford M, Peggie M, Cohen P | title = Interleukin-1 (IL-1) induces the Lys63-linked polyubiquitination of IL-1 receptor-associated kinase 1 to facilitate NEMO binding and the activation of IkappaBalpha kinase | url = https://archive.org/details/sim_molecular-and-cellular-biology_2008-03_28_5/page/1782 | journal = Mol. Cell. Biol. | volume = 28 | issue = 5 | pages = 1783–91 | date = March 2008 | pmid = 18180283 | pmc = 2258775 | doi = 10.1128/MCB.02380-06 }}</ref><ref name = pmid11259596/><ref name = pmid10882101>{{cite journal | vauthors = Takaesu G, Kishida S, Hiyama A, Yamaguchi K, Shibuya H, Irie K, Ninomiya-Tsuji J, Matsumoto K | title = TAB2, a novel adaptor protein, mediates activation of TAK1 MAPKKK by linking TAK1 to TRAF6 in the IL-1 signal transduction pathway | journal = Mol. Cell | volume = 5 | issue = 4 | pages = 649–58 | date = April 2000 | pmid = 10882101 | doi = 10.1016/s1097-2765(00)80244-0| doi-access = free }}</ref><ref name = pmid19112497>{{cite journal | vauthors = Walsh MC, Kim GK, Maurizio PL, Molnar EE, Choi Y | title = TRAF6 autoubiquitination-independent activation of the NFkappaB and MAPK pathways in response to IL-1 and RANKL | journal = PLOS ONE | volume = 3 | issue = 12 | pages = e4064 | pmid = 19112497 | pmc = 2603309 | doi = 10.1371/journal.pone.0004064 | editor1-last = Unutmaz | editor1-first = Derya | year=2008| doi-access = free | bibcode = 2008PLoSO...3.4064W }}</ref><ref name = pmid14633987>{{cite journal |author5-link=Richard Gaynor | vauthors = Ishitani T, Takaesu G, Ninomiya-Tsuji J, Shibuya H, Gaynor RB, Matsumoto K | title = Role of the TAB2-related protein TAB3 in IL-1 and TNF signaling |url=https://archive.org/details/sim_embo-journal_2003-12-01_22_23/page/6276 | journal = EMBO J. | volume = 22 | issue = 23 | pages = 6277–88 | date = Dec 2003 | pmid = 14633987 | pmc = 291846 | doi = 10.1093/emboj/cdg605 }}</ref><ref name = pmid18299187>{{cite journal | vauthors = Ma Q, Zhou L, Shi H, Huo K | title = NUMBL interacts with TAB2 and inhibits TNFalpha and IL-1beta-induced NF-kappaB activation | journal = Cell. Signal. | volume = 20 | issue = 6 | pages = 1044–51 | date = June 2008 | pmid = 18299187 | doi = 10.1016/j.cellsig.2008.01.015 }}</ref>
* [[MAP3K7]]<ref name = pmid10921914/><ref name = pmid11259596/><ref name = pmid10882101/><ref name = pmid19112497/><ref name = pmid10094049/><ref name = pmid14633987/><ref name = pmid18758450>{{cite journal | vauthors = Sorrentino A, Thakur N, Grimsby S, Marcusson A, von Bulow V, Schuster N, Zhang S, Heldin CH, Landström M | title = The type I TGF-beta receptor engages TRAF6 to activate TAK1 in a receptor kinase-independent manner | journal = Nat. Cell Biol. | volume = 10 | issue = 10 | pages = 1199–207 | date = October 2008 | pmid = 18758450 | doi = 10.1038/ncb1780 | s2cid = 22984417 }}</ref>
* [[PPP4C]]<ref name = pmid18634786>{{cite journal | vauthors = Chen L, Dong W, Zou T, Ouyang L, He G, Liu Y, Qi Y | title = Protein phosphatase 4 negatively regulates LPS cascade by inhibiting ubiquitination of TRAF6 | journal = FEBS Lett. | volume = 582 | issue = 19 | pages = 2843–9 | date = August 2008 | pmid = 18634786 | doi = 10.1016/j.febslet.2008.07.014 | s2cid = 27700566 | doi-access = free | bibcode = 2008FEBSL.582.2843C }}</ref>
* [[RANK]]<ref name = pmid11809792>{{cite journal | vauthors = Mizukami J, Takaesu G, Akatsuka H, Sakurai H, Ninomiya-Tsuji J, Matsumoto K, Sakurai N | title = Receptor activator of NF-kappaB ligand (RANKL) activates TAK1 mitogen-activated protein kinase kinase kinase through a signaling complex containing RANK, TAB2, and TRAF6 | url = https://archive.org/details/sim_molecular-and-cellular-biology_2002-02_22_4/page/992 | journal = Mol. Cell. Biol. | volume = 22 | issue = 4 | pages = 992–1000 | date = February 2002 | pmid = 11809792 | pmc = 134634 | doi = 10.1128/mcb.22.4.992-1000.2002}}</ref><ref name = pmid9685412>{{cite journal | vauthors = Darnay BG, Haridas V, Ni J, Moore PA, Aggarwal BB | title = Characterization of the intracellular domain of receptor activator of NF-kappaB (RANK). Interaction with tumor necrosis factor receptor-associated factors and activation of NF-kappab and c-Jun N-terminal kinase | url = https://archive.org/details/sim_journal-of-biological-chemistry_1998-08-07_273_32/page/20550 | journal = J. Biol. Chem. | volume = 273 | issue = 32 | pages = 20551–5 | date = August 1998 | pmid = 9685412 | doi = 10.1074/jbc.273.32.20551| doi-access = free }}</ref><ref name = pmid10075662>{{cite journal | vauthors = Darnay BG, Ni J, Moore PA, Aggarwal BB | title = Activation of NF-kappaB by RANK requires tumor necrosis factor receptor-associated factor (TRAF) 6 and NF-kappaB-inducing kinase. Identification of a novel TRAF6 interaction motif | url = https://archive.org/details/sim_journal-of-biological-chemistry_1999-03-19_274_12/page/7724 | journal = J. Biol. Chem. | volume = 274 | issue = 12 | pages = 7724–31 | date = March 1999 | pmid = 10075662 | doi = 10.1074/jbc.274.12.7724| doi-access = free}}</ref><ref name = pmid9852070>{{cite journal | vauthors = Galibert L, Tometsko ME, Anderson DM, Cosman D, Dougall WC | title = The involvement of multiple tumor necrosis factor receptor (TNFR)-associated factors in the signaling mechanisms of receptor activator of NF-kappaB, a member of the TNFR superfamily | url = https://archive.org/details/sim_journal-of-biological-chemistry_1998-12-18_273_51/page/34120 | journal = J. Biol. Chem. | volume = 273 | issue = 51 | pages = 34120–7 | date = Dec 1998 | pmid = 9852070 | doi = 10.1074/jbc.273.51.34120| doi-access = free }}</ref><ref name = pmid10025951>{{cite journal | vauthors = Kim HH, Lee DE, Shin JN, Lee YS, Jeon YM, Chung CH, Ni J, Kwon BS, Lee ZH | title = Receptor activator of NF-kappaB recruits multiple TRAF family adaptors and activates c-Jun N-terminal kinase | url = https://archive.org/details/sim_febs-letters_1999-01-29_443_3/page/296 | journal = FEBS Lett. | volume = 443 | issue = 3 | pages = 297–302 | date = January 1999 | pmid = 10025951 | doi = 10.1016/s0014-5793(98)01731-1| s2cid = 46210019 | doi-access = free | bibcode = 1999FEBSL.443..297K }}</ref>
* [[SDCBP]]<ref name = pmid18234474>{{cite journal | vauthors = Chen F, Du Y, Zhang Z, Chen G, Zhang M, Shu HB, Zhai Z, Chen D | title = Syntenin negatively regulates TRAF6-mediated IL-1R/TLR4 signaling | journal = Cell. Signal. | volume = 20 | issue = 4 | pages = 666–74 | date = April 2008 | pmid = 18234474 | doi = 10.1016/j.cellsig.2007.12.002 | s2cid = 28812149 }}</ref>
* [[SIGIRR]]<ref name = pmid12925853>{{cite journal | vauthors = Wald D, Qin J, Zhao Z, Qian Y, Naramura M, Tian L, Towne J, Sims JE, Stark GR, Li X | title = SIGIRR, a negative regulator of Toll-like receptor-interleukin 1 receptor signaling | journal = Nat. Immunol. | volume = 4 | issue = 9 | pages = 920–7 | date = September 2003 | pmid = 12925853 | doi = 10.1038/ni968 | s2cid = 25246605 }}</ref>
* [[Sequestosome 1]]<ref name = pmid10747026>{{cite journal | vauthors = Sanz L, Diaz-Meco MT, Nakano H, Moscat J | title = The atypical PKC-interacting protein p62 channels NF-kappaB activation by the IL-1-TRAF6 pathway | url = https://archive.org/details/sim_embo-journal_2000-04-03_19_7/page/1576 | journal = EMBO J. | volume = 19 | issue = 7 | pages = 1576–86 | date = April 2000 | pmid = 10747026 | pmc = 310227 | doi = 10.1093/emboj/19.7.1576 }}</ref>
* [[TAX1BP1]]<ref name = pmid10920205/>
* [[A20 (基因)|TNFAIP3]]<ref name = pmid9928991>{{cite journal | vauthors = Heyninck K, Beyaert R | title = The cytokine-inducible zinc finger protein A20 inhibits IL-1-induced NF-kappaB activation at the level of TRAF6 | journal = FEBS Lett. | volume = 442 | issue = 2–3 | pages = 147–50 | date = January 1999 | pmid = 9928991 | doi = 10.1016/s0014-5793(98)01645-7| s2cid = 19072203 | doi-access = free | bibcode = 1999FEBSL.442..147H }}</ref><ref name = pmid11463333>{{cite journal | vauthors = Evans PC, Taylor ER, Coadwell J, Heyninck K, Beyaert R, Kilshaw PJ | title = Isolation and characterization of two novel A20-like proteins | journal = Biochem. J. | volume = 357 | issue = Pt 3 | pages = 617–23 | date = August 2001 | pmid = 11463333 | pmc = 1221992 | doi = 10.1042/0264-6021:3570617}}</ref>
* [[TNFRSF13B]]<ref name = pmid10880535>{{cite journal | vauthors = Xia XZ, Treanor J, Senaldi G, Khare SD, Boone T, Kelley M, Theill LE, Colombero A, Solovyev I, Lee F, McCabe S, Elliott R, Miner K, Hawkins N, Guo J, Stolina M, Yu G, Wang J, Delaney J, Meng SY, Boyle WJ, Hsu H | title = TACI is a TRAF-interacting receptor for TALL-1, a tumor necrosis factor family member involved in B cell regulation | journal = J. Exp. Med. | volume = 192 | issue = 1 | pages = 137–43 | date = July 2000 | pmid = 10880535 | pmc = 1887716 | doi = 10.1084/jem.192.1.137}}</ref>
* [[UBE2N]]<ref name = pmid11057907>{{cite journal | vauthors = Deng L, Wang C, Spencer E, Yang L, Braun A, You J, Slaughter C, Pickart C, Chen ZJ | title = Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain | journal = Cell | volume = 103 | issue = 2 | pages = 351–61 | date = October 2000 | pmid = 11057907 | doi = 10.1016/s0092-8674(00)00126-4| s2cid = 18154645 | doi-access = free }}</ref>
* [[Ubiquitin C]]<ref name = pmid18617513/><ref name = pmid18299187/><ref name = pmid18634786/><ref name = pmid18724939>{{cite journal | vauthors = Newton K, Matsumoto ML, Wertz IE, Kirkpatrick DS, Lill JR, Tan J, Dugger D, Gordon N, Sidhu SS, Fellouse FA, Komuves L, French DM, Ferrando RE, Lam C, Compaan D, Yu C, Bosanac I, Hymowitz SG, Kelley RF, Dixit VM | title = Ubiquitin chain editing revealed by polyubiquitin linkage-specific antibodies | journal = Cell | volume = 134 | issue = 4 | pages = 668–78 | date = August 2008 | pmid = 18724939 | doi = 10.1016/j.cell.2008.07.039 | s2cid = 3955385 | doi-access = free }}</ref><ref name = pmid18347055>{{cite journal | vauthors = Conze DB, Wu CJ, Thomas JA, Landstrom A, Ashwell JD | title = Lys63-linked polyubiquitination of IRAK-1 is required for interleukin-1 receptor- and toll-like receptor-mediated NF-kappaB activation | url = https://archive.org/details/sim_molecular-and-cellular-biology_2008-05_28_10/page/3538 | journal = Mol. Cell. Biol. | volume = 28 | issue = 10 | pages = 3538–47 | date = May 2008 | pmid = 18347055 | pmc = 2423148 | doi = 10.1128/MCB.02098-07 }}</ref>
{{Div col end}}

==参考文献==
{{reflist}}

==外部链接==
* {{MeshName|TRAF6}}

{{TLR信号通路}}

TRAF6 - 版本历史

imported>InternetArchiveBot：​Add 19 books for verifiability (20251017sim)) #IABot (v2.0.9.5) (GreenC bot

imported>InternetArchiveBot：Add 19 books for verifiability (20251017sim)) #IABot (v2.0.9.5) (GreenC bot