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{{PBB|geneid=6778}}
'''信号转导及转录激活蛋白6'''（{{langx|en|Signal transducer and activator of transcription 6}}，'''STAT6'''）是一种由人类[[基因]]''STAT6'' 编码的[[转录因子]]<ref name="pmid9605853">{{cite journal | author = Leek JP, Hamlin PJ, Bell SM, Lench NJ | title = Assignment of the STAT6 gene (STAT6) to human chromosome band 12q13 by in situ hybridization | journal = Cytogenet. Cell Genet. | volume = 79 | issue = 3–4 | pages = 208–9 | year = 1997 | pmid = 9605853 | url = | doi = 10.1159/000134723 }}</ref><ref name="pmid8085155">{{cite journal | author = Hou J, Schindler U, Henzel WJ, Ho TC, Brasseur M, McKnight SL | title = An interleukin-4-induced transcription factor: IL-4 Stat | journal = Science | volume = 265 | issue = 5179 | pages = 1701–6 |date=September 1994 | pmid = 8085155 | url = http://www.sciencemag.org/cgi/pmidlookup?view=long&pmid=8085155 | doi = 10.1126/science.8085155 }}</ref>。

==相互作用==
STAT3能与下列蛋白質发生[[蛋白質交互作用|交互作用]]：

[[EP300]],<ref name=pmid10454341>{{cite journal |last=McDonald |first=C |authorlink= |author2=Reich N C |date=July 1999 |title=Cooperation of the transcriptional coactivators CBP and p300 with Stat6 |journal=J. Interferon Cytokine Res. |volume=19 |issue=7 |pages=711–22 |publisher= |location = UNITED STATES| issn = 1079-9907| pmid = 10454341 |doi = 10.1089/107999099313550 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref>[[CREB-binding protein]],<ref name=pmid10454341/><ref name=pmid11574547>{{cite journal |last=Litterst |first=C M |authorlink= |author2=Pfitzner E |date=Dec 2001 |title=Transcriptional activation by STAT6 requires the direct interaction with NCoA-1 |journal=J. Biol. Chem. |volume=276 |issue=49 |pages=45713–21 |publisher= |location = United States| issn = 0021-9258| pmid = 11574547 |doi = 10.1074/jbc.M108132200 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref>[[NFKB1]],<ref name=pmid9584180>{{cite journal |last=Shen |first=C H |authorlink= |author2=Stavnezer J |date=June 1998 |title=Interaction of stat6 and NF-kappaB: direct association and synergistic activation of interleukin-4-induced transcription |journal=Mol. Cell. Biol. |volume=18 |issue=6 |pages=3395–404 |publisher= |location = UNITED STATES| issn = 0270-7306| pmid = 9584180 | bibcode = | oclc =| id = | url =https://archive.org/details/sim_molecular-and-cellular-biology_1998-06_18_6/page/3395| language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=108921 }}</ref>[[Nuclear receptor coactivator 1]],<ref name=pmid11574547/><ref name=pmid12138096>{{cite journal |last=Litterst |first=Claudia M |authorlink= |author2=Pfitzner Edith |date=September 2002 |title=An LXXLL motif in the transactivation domain of STAT6 mediates recruitment of NCoA-1/SRC-1 |journal=J. Biol. Chem. |volume=277 |issue=39 |pages=36052–60 |publisher= |location = United States| issn = 0021-9258| pmid = 12138096 |doi = 10.1074/jbc.M203556200 | bibcode = | oclc =| id = | url =https://archive.org/details/sim_journal-of-biological-chemistry_2002-09-27_277_39/page/36052| language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref>[[IRF4]]<ref name=pmid10601358>{{cite journal |last=Gupta |first=S |authorlink= |author2=Jiang M|author3=Anthony A|author4=Pernis A B |date=Dec 1999 |title=Lineage-specific modulation of interleukin 4 signaling by interferon regulatory factor 4 |journal=J. Exp. Med. |volume=190 |issue=12 |pages=1837–48 |publisher= |location = UNITED STATES| issn = 0022-1007| pmid = 10601358 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1084/jem.190.12.1837 |pmc=2195723 }}</ref>和[[SND1]]<ref name=pmid12234934>{{cite journal |last=Yang |first=Jie |authorlink= |author2=Aittomäki Saara|author3=Pesu Marko|author4=Carter Kara|author5=Saarinen Jussi|author6=Kalkkinen Nisse|author7=Kieff Elliott|author8=Silvennoinen Olli |date=September 2002 |title=Identification of p100 as a coactivator for STAT6 that bridges STAT6 with RNA polymerase II |journal=EMBO J. |volume=21 |issue=18 |pages=4950–8 |publisher= |location = England| issn = 0261-4189| pmid = 12234934 | bibcode = | oclc =| id = | url =https://archive.org/details/sim_embo-journal_2002-09-16_21_18/page/4950| language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1093/emboj/cdf463 |pmc=126276 }}</ref>。

==另见==
* [[白细胞介素-4]]

==参考文献==
{{Reflist}}

==延伸阅读==
{{Refbegin | 2}}
{{PBB Further reading
| citations =
*{{cite journal | author=Jiang H, Harris MB, Rothman P |title=IL-4/IL-13 signaling beyond JAK/STAT |journal=J. Allergy Clin. Immunol. |volume=105 |issue= 6 Pt 1 |pages= 1063–70 |year= 2000 |pmid= 10856136 |doi=10.1067/mai.2000.107604 }}
*{{cite journal | author=Kisseleva T, Bhattacharya S, Braunstein J, Schindler CW |title=Signaling through the JAK/STAT pathway, recent advances and future challenges |journal=Gene |volume=285 |issue= 1–2 |pages= 1–24 |year= 2002 |pmid= 12039028 |doi=10.1016/S0378-1119(02)00398-0 }}
*{{cite journal | author=Hou J, Schindler U, Henzel WJ, ''et al.'' |title=An interleukin-4-induced transcription factor: IL-4 Stat | url=https://archive.org/details/sim_science_1994-09-16_265_5179/page/1700 |journal=Science |volume=265 |issue= 5179 |pages= 1701–6 |year= 1994 |pmid= 8085155 |doi=10.1126/science.8085155 }}
*{{cite journal | author=Takeda K, Tanaka T, Shi W, ''et al.'' |title=Essential role of Stat6 in IL-4 signalling | url=https://archive.org/details/sim_nature-uk_1996-04-18_380_6575/page/626 |journal=Nature |volume=380 |issue= 6575 |pages= 627–30 |year= 1996 |pmid= 8602263 |doi= 10.1038/380627a0 }}
*{{cite journal | author=Shimoda K, van Deursen J, Sangster MY, ''et al.'' |title=Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted Stat6 gene | url=https://archive.org/details/sim_nature-uk_1996-04-18_380_6575/page/630 |journal=Nature |volume=380 |issue= 6575 |pages= 630–3 |year= 1996 |pmid= 8602264 |doi= 10.1038/380630a0 }}
*{{cite journal | author=Kotanides H, Reich NC |title=Interleukin-4-induced STAT6 recognizes and activates a target site in the promoter of the interleukin-4 receptor gene | url=https://archive.org/details/sim_journal-of-biological-chemistry_1996-10-11_271_41/page/25554 |journal=J. Biol. Chem. |volume=271 |issue= 41 |pages= 25555–61 |year= 1996 |pmid= 8810328 |doi=10.1074/jbc.271.41.25555 }}
*{{cite journal | author=Mikita T, Campbell D, Wu P, ''et al.'' |title=Requirements for interleukin-4-induced gene expression and functional characterization of Stat6 | url=https://archive.org/details/sim_molecular-and-cellular-biology_1996-10_16_10/page/5811 |journal=Mol. Cell. Biol. |volume=16 |issue= 10 |pages= 5811–20 |year= 1996 |pmid= 8816495 |doi= | pmc=231582 }}
*{{cite journal | author=Shen CH, Stavnezer J |title=Interaction of stat6 and NF-kappaB: direct association and synergistic activation of interleukin-4-induced transcription | url=https://archive.org/details/sim_molecular-and-cellular-biology_1998-06_18_6/page/3395 |journal=Mol. Cell. Biol. |volume=18 |issue= 6 |pages= 3395–404 |year= 1998 |pmid= 9584180 |doi= | pmc=108921 }}
*{{cite journal | author=Leek JP, Hamlin PJ, Bell SM, Lench NJ |title=Assignment of the STAT6 gene (STAT6) to human chromosome band 12q13 by in situ hybridization |journal=Cytogenet. Cell Genet. |volume=79 |issue= 3–4 |pages= 208–9 |year= 1998 |pmid= 9605853 |doi=10.1159/000134723 }}
*{{cite journal | author=Mikita T, Kurama M, Schindler U |title=Synergistic activation of the germline epsilon promoter mediated by Stat6 and C/EBP beta | url=https://archive.org/details/sim_journal-of-immunology_1998-08-15_161_4/page/1822 |journal=J. Immunol. |volume=161 |issue= 4 |pages= 1822–8 |year= 1998 |pmid= 9712049 |doi= }}
*{{cite journal | author=Patel BK, Keck CL, O'Leary RS, ''et al.'' |title=Localization of the human stat6 gene to chromosome 12q13.3-q14.1, a region implicated in multiple solid tumors |journal=Genomics |volume=52 |issue= 2 |pages= 192–200 |year= 1998 |pmid= 9782085 |doi= 10.1006/geno.1998.5436 }}
*{{cite journal | author=Zhu M, John S, Berg M, Leonard WJ |title=Functional association of Nmi with Stat5 and Stat1 in IL-2- and IFNgamma-mediated signaling |journal=Cell |volume=96 |issue= 1 |pages= 121–30 |year= 1999 |pmid= 9989503 |doi=10.1016/S0092-8674(00)80965-4 }}
*{{cite journal | author=McDonald C, Reich NC |title=Cooperation of the transcriptional coactivators CBP and p300 with Stat6 |journal=J. Interferon Cytokine Res. |volume=19 |issue= 7 |pages= 711–22 |year= 1999 |pmid= 10454341 |doi= 10.1089/107999099313550 }}
*{{cite journal | author=Harris MB, Chang CC, Berton MT, ''et al.'' |title=Transcriptional repression of Stat6-dependent interleukin-4-induced genes by BCL-6: specific regulation of iepsilon transcription and immunoglobulin E switching |journal=Mol. Cell. Biol. |volume=19 |issue= 10 |pages= 7264–75 |year= 2000 |pmid= 10490661 |doi= | pmc=84719 }}
*{{cite journal | author=Gupta S, Jiang M, Pernis AB |title=IFN-alpha activates Stat6 and leads to the formation of Stat2:Stat6 complexes in B cells | url=https://archive.org/details/sim_journal-of-immunology_1999-10-01_163_7/page/3834 |journal=J. Immunol. |volume=163 |issue= 7 |pages= 3834–41 |year= 1999 |pmid= 10490982 |doi= }}
*{{cite journal | author=Gupta S, Jiang M, Anthony A, Pernis AB |title=Lineage-specific modulation of interleukin 4 signaling by interferon regulatory factor 4 |journal=J. Exp. Med. |volume=190 |issue= 12 |pages= 1837–48 |year= 2000 |pmid= 10601358 |doi=10.1084/jem.190.12.1837 | pmc=2195723 }}
*{{cite journal | author=Daniel C, Salvekar A, Schindler U |title=A gain-of-function mutation in STAT6 | url=https://archive.org/details/sim_journal-of-biological-chemistry_2000-05-12_275_19/page/14254 |journal=J. Biol. Chem. |volume=275 |issue= 19 |pages= 14255–9 |year= 2000 |pmid= 10747856 |doi=10.1074/jbc.C000129200 }}
*{{cite journal | author=Arinobu Y, Sugimoto R, Akaiwa M, ''et al.'' |title=Augmentation of signal transducer and activation of transcription (STAT)6 and STAT3 expression in stimulated B and T cells |journal=Biochem. Biophys. Res. Commun. |volume=277 |issue= 2 |pages= 317–24 |year= 2000 |pmid= 11032724 |doi= 10.1006/bbrc.2000.3674 }}
*{{cite journal | author=Masuda A, Matsuguchi T, Yamaki K, ''et al.'' |title=Interleukin-15 prevents mouse mast cell apoptosis through STAT6-mediated Bcl-xL expression | url=https://archive.org/details/sim_journal-of-biological-chemistry_2001-07-13_276_28/page/26106 |journal=J. Biol. Chem. |volume=276 |issue= 28 |pages= 26107–13 |year= 2001 |pmid= 11369758 |doi= 10.1074/jbc.M011475200 }}
}}
{{Refend}}

==外部链接==
* {{MeshName|STAT6+Transcription+Factor}}

{{Transcription factors|g4}}
{{JAK-STAT信号通路}}


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[[Category:基因表現]]
[[Category:免疫系统]]
[[Category:转录因子]]
[[Category:信号转导]]

STAT6 - 版本历史

imported>InternetArchiveBot：​Add 10 books for verifiability (20251017sim)) #IABot (v2.0.9.5) (GreenC bot

imported>InternetArchiveBot：Add 10 books for verifiability (20251017sim)) #IABot (v2.0.9.5) (GreenC bot