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{{Infobox_gene}}
'''SRY盒-2'''（SRY：性別決定區，'''S'''ex Determining '''R'''egion '''Y'''），化学式为：C1469H2325O457N443S26<ref>{{Cite web |title=Expasy - ProtParam |url=https://web.expasy.org/cgi-bin/protparam/protparam_bis.cgi?P48431@1-317@ |website=web.expasy.org |access-date=2026-01-24}}</ref>，又稱「'''Sox2'''」（人的Sox2應寫爲'''SOX2'''），是一種對未分化的[[胚胎幹細胞]]（ESC）、神經幹細胞等再生能力以及[[細胞潛能|多能性]]維持至關重要[[轉錄因子]]<ref name=":0">{{Cite web|url = http://www.ncbi.nlm.nih.gov/gene/6657|title = SOX2|date = |accessdate = |website = |publisher = NCBI|archive-date = 2016-01-05|archive-url = https://web.archive.org/web/20160105122858/http://www.ncbi.nlm.nih.gov/gene/6657|dead-url = no}}</ref>。對Sox2的研究對幹細胞生物學、[[再生醫學]]的發展有重要意義<ref name="pmid20016762">{{cite journal | vauthors = Rizzino A | title = Sox2 and Oct-3/4: a versatile pair of master regulators that orchestrate the self-renewal and pluripotency of embryonic stem cells | journal = Wiley Interdisciplinary Reviews. Systems Biology and Medicine | volume = 1 | issue = 2 | pages = 228–36 | year = 2009 | pmid = 20016762 | pmc = 2794141 | doi = 10.1002/wsbm.12 }}</ref>。

Sox2隸屬於[[SOX基因家族|SOX]][[轉錄因子]][[蛋白質家族|家族]]。Sox轉錄因子家族在哺乳動物的發育過程中扮演重要角色。該家族的蛋白質都有一個保守的DNA結合[[結構域]]，長約80個氨基酸殘基，稱爲[[高迁移率组]]（High-mobility group，HMG）盒結構域<ref name=":0" />。

== 功能 ==
=== 幹性維持 ===
[[白血病抑制因子]]（LIF）能通過激活Sox2調控的下游，諸如[[JAK-STAT信號通路]]，繼而激活[[Klf4]]（[[Kruppel樣因子]]家族下的一種蛋白質）的表達，以維持[[胚胎幹細胞]]的幹性。[[Oct4]]、Sox2以及[[Nanog]]能增強所有LIF調控的通路相關的蛋白質的表達<ref name="pmid19571885">{{cite journal | vauthors = Niwa H, Ogawa K, Shimosato D, Adachi K | title = A parallel circuit of LIF signalling pathways maintains pluripotency of mouse ES cells | url = https://archive.org/details/sim_nature-uk_2009-07-02_460_7251/page/118 | journal = Nature | volume = 460 | issue = 7251 | pages = 118–22 | date = July 2009 | pmid = 19571885 | doi = 10.1038/nature08113 }}</ref>。

{{link-en|Npm1|Npm1}}是一種與細胞增殖相關的轉錄調節蛋白，在胚胎幹細胞中能與Sox2、Oct4、Nanog形成[[蛋白複合物]]<ref name="pmid21076177">{{cite journal | vauthors = Johansson H, Simonsson S | title = Core transcription factors, Oct4, Sox2 and Nanog, individually form complexes with nucleophosmin (Npm1) to control embryonic stem (ES) cell fate determination | journal = Aging | volume = 2 | issue = 11 | pages = 815–22 | date = November 2010 | pmid = 21076177 | pmc = 3006024 | doi = 10.18632/aging.100222 }}</ref>。Sox2、Oct4、Nanog三個轉錄因子共同組成了一個與多能性維持相關的轉錄調控網絡。Sox2能與Oct4一同與DNA非回文序列結合，以激活與多能性維持的關鍵因子轉錄<ref name="Chambers_Tomlinson_2009">{{cite journal | vauthors = Chambers I, Tomlinson SR | title = The transcriptional foundation of pluripotency | journal = Development | volume = 136 | issue = 14 | pages = 2311–22 | date = July 2009 | pmid = 19542351 | pmc = 2729344 | doi = 10.1242/dev.024398 }}</ref>。令人驚訝的是，對Oct4-Sox2增強子的調控即使沒有Sox2也可以發生，可能是因爲其他Sox家族的蛋白質的表達。不過，已有研究人員確認Sox2在胚胎幹細胞幹性維持中的主要作用是控制Oct4的表達。另外，Oct4、Sox2一旦表達，就會自我維持持續表達的狀態<ref name="pmid17515932">{{cite journal | vauthors = Masui S, Nakatake Y, Toyooka Y, Shimosato D, Yagi R, Takahashi K, Okochi H, Okuda A, Matoba R, Sharov AA, Ko MS, Niwa H | title = Pluripotency governed by Sox2 via regulation of Oct3/4 expression in mouse embryonic stem cells | journal = Nature Cell Biology | volume = 9 | issue = 6 | pages = 625–35 | date = June 2007 | pmid = 17515932 | doi = 10.1038/ncb1589 }}</ref>。

向體細胞中轉入Sox2加上Oct4、[[c-Myc]]、Klf4四個因子的基因就可以誘導[[iPSC]]的產生<ref name="Takahashi_Yamanaka_2006">{{cite journal | vauthors = Takahashi K, Yamanaka S | title = Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors | journal = Cell | volume = 126 | issue = 4 | pages = 663–76 | date = August 2006 | pmid = 16904174 | doi = 10.1016/j.cell.2006.07.024 }}</ref>。

一些Sox2、Oct4的結合位點的高甲基化以及[[miRNA|miR]]134對Sox2的轉錄後抑制調控男性生殖細胞多能性丟失<ref name="Imamura_2006">{{cite journal | vauthors = Imamura M, Miura K, Iwabuchi K, Ichisaka T, Nakagawa M, Lee J, Kanatsu-Shinohara M, Shinohara T, Yamanaka S | title = Transcriptional repression and DNA hypermethylation of a small set of ES cell marker genes in male germline stem cells | journal = BMC Developmental Biology | volume = 6 | issue = | pages = 34 | year = 2006 | pmid = 16859545 | pmc = 1564388 | doi = 10.1186/1471-213X-6-34 }}</ref><ref name="Tay_2008">{{cite journal | vauthors = Tay Y, Zhang J, Thomson AM, Lim B, Rigoutsos I | title = MicroRNAs to Nanog, Oct4 and Sox2 coding regions modulate embryonic stem cell differentiation | url = https://archive.org/details/sim_nature-uk_2008-10-23_455_7216/page/1124 | journal = Nature | volume = 455 | issue = 7216 | pages = 1124–8 | date = October 2008 | pmid = 18806776 | doi = 10.1038/nature07299 }}</ref>。

Sox2不同的表達水平決定了胚胎幹細胞的分化命運。Sox2能抑制胚胎幹細胞分化爲中胚層、內胚層的細胞，並能促進其分化爲外胚層的[[神經細胞]]<ref name="Thomson_2011">{{cite journal | vauthors = Thomson M, Liu SJ, Zou LN, Smith Z, Meissner A, Ramanathan S | title = Pluripotency factors in embryonic stem cells regulate differentiation into germ layers | journal = Cell | volume = 145 | issue = 6 | pages = 875–89 | date = June 2011 | pmid = 21663792 | doi = 10.1016/j.cell.2011.05.017 }}</ref>。在細胞分化爲外胚層系細胞的過程中，Npm1/Sox2複合物能持續表達，說明Sox2在外胚層分化過程中發揮的重要作用<ref name="pmid21076177" />。

通過對基因敲除鼠的研究，已證明Sox2表達的缺失會使神經畸形，對胚胎是致死的。進一步說明Sox2對胚胎發育的重要性<ref name="Feri_et_al_2004">{{cite journal | vauthors = Ferri AL, Cavallaro M, Braida D, Di Cristofano A, Canta A, Vezzani A, Ottolenghi S, Pandolfi PP, Sala M, DeBiasi S, Nicolis SK | title = Sox2 deficiency causes neurodegeneration and impaired neurogenesis in the adult mouse brain | journal = Development | volume = 131 | issue = 15 | pages = 3805–19 | date = August 2004 | pmid = 15240551 | doi = 10.1242/dev.01204 }}</ref>。

====神經幹細胞====
[[神經發生]]過程中，Sox2在[[神經管]]細胞以及[[中樞神經系統]]祖細胞增殖過程中會表達。然而，在祖細胞退出細胞週期，進入G0期的過程中，Sox2的表達會下調<ref name="Graham">{{cite journal | vauthors = Graham V, Khudyakov J, Ellis P, Pevny L | title = SOX2 functions to maintain neural progenitor identity | journal = Neuron | volume = 39 | issue = 5 | pages = 749–65 | date = August 2003 | pmid = 12948443 | doi = 10.1016/S0896-6273(03)00497-5 }}</ref>。細胞表達Sox2能促進細胞增殖，也能促進細胞分化爲神經細胞，而細胞增殖和分化的能力正是幹細胞的兩個最顯著的特徵。表達Sox2的（Sox2+）[[神經幹細胞]]能進行細胞分裂，產生與其相同的Sox2+神經幹細胞，同時還能產生神經細胞前體細胞<ref name="Suh_2007">{{cite journal | vauthors = Suh H, Consiglio A, Ray J, Sawai T, D'Amour KA, Gage FH | title = In vivo fate analysis reveals the multipotent and self-renewal capacities of Sox2+ neural stem cells in the adult hippocampus | journal = Cell Stem Cell | volume = 1 | issue = 5 | pages = 515–28 | date = November 2007 | pmid = 18371391 | pmc = 2185820 | doi = 10.1016/j.stem.2007.09.002 }}</ref>。

使用成體神經幹細胞（其Sox2以及c-Myc的表達水平高於胚胎幹細胞），只需要轉入兩種因子（其中一個必須是Oct4）就足以產生誘導多能性幹細胞，減少了轉入多個因子時可能產生的風險以及副作用<ref name="pmid18594515">{{cite journal | vauthors = Kim JB, Zaehres H, Wu G, Gentile L, Ko K, Sebastiano V, Araúzo-Bravo MJ, Ruau D, Han DW, Zenke M, Schöler HR | title = Pluripotent stem cells induced from adult neural stem cells by reprogramming with two factors | url = https://archive.org/details/sim_nature-uk_2008-07-31_454_7204/page/646 | journal = Nature | volume = 454 | issue = 7204 | pages = 646–50 | date = July 2008 | pmid = 18594515 | doi = 10.1038/nature07061 }}</ref>。

=== 眼畸形 ===
人''SOX2''基因突變與双眼[[眼球炎]]，一種嚴重的結構性眼畸形有關<ref name="entrez">{{cite web| title = Entrez Gene: SOX2 SRY (sex determining region Y)-box 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6657| accessdate = | archive-date = 2010-04-13| archive-url = https://web.archive.org/web/20100413033139/http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6657| dead-url = no}}</ref>。

===癌症===
在肺發育過程中，Sox2控制支氣管分支的形態發生以及空氣通道上皮的分化<ref name="Gontan_2008">{{cite journal | vauthors = Gontan C, de Munck A, Vermeij M, Grosveld F, Tibboel D, Rottier R | title = Sox2 is important for two crucial processes in lung development: branching morphogenesis and epithelial cell differentiation | journal = Developmental Biology | volume = 317 | issue = 1 | pages = 296–309 | date = May 2008 | pmid = 18374910 | doi = 10.1016/j.ydbio.2008.02.035 }}</ref>。在通常情況下，Sox2對氣管上皮的基底細胞的自我更新以及比例維持至關重要。然而，Sox2的過表達會造成上皮增生，並最終在發育中以及成體小鼠體內誘發肺部癌變<ref name="Lu_2010">{{cite journal | vauthors = Lu Y, Futtner C, Rock JR, Xu X, Whitworth W, Hogan BL, Onaitis MW | title = Evidence that SOX2 overexpression is oncogenic in the lung | journal = PLoS ONE | volume = 5 | issue = 6 | pages = e11022 | year = 2010 | pmid = 20548776 | pmc = 2883553 | doi = 10.1371/journal.pone.0011022 }}</ref>。

[[鳞状细胞癌]]中，常常可以檢出3q26.3區基因的擴增。''Sox2''基因即位於該區域，說明Sox2是一種[[原癌基因]]。Sox2能誘發鱗狀細胞癌，激活許多與腫瘤發生相關的基因表達。Sox2的過表達與Lkb1的不表達能促進小鼠肺部鱗狀上皮細胞的癌變<ref>{{cite journal | vauthors = Mukhopadhyay A, Berrett KC, Kc U, Clair PM, Pop SM, Carr SR, Witt BL, Oliver TG | title = Sox2 cooperates with Lkb1 loss in a mouse model of squamous cell lung cancer | journal = Cell Reports | volume = 8 | issue = 1 | pages = 40–9 | date = July 2014 | pmid = 24953650 | doi = 10.1016/j.celrep.2014.05.036 }}</ref>。Sox2的過表達也可以激活細胞的遷移以及錨定非依賴性生長<ref name="Hussenet_2010">{{cite journal | vauthors = Hussenet T, Dali S, Exinger J, Monga B, Jost B, Dembelé D, Martinet N, Thibault C, Huelsken J, Brambilla E, du Manoir S | title = SOX2 is an oncogene activated by recurrent 3q26.3 amplifications in human lung squamous cell carcinomas | journal = PLoS ONE | volume = 5 | issue = 1 | pages = e8960 | year = 2010 | pmid = 20126410 | pmc = 2813300 | doi = 10.1371/journal.pone.0008960 }}</ref>。

Sox2表達與高{{link-en|格里森分级|gleason grade}}的前列腺癌有關，能促進[[去势抵抗性前列腺癌]]的生長<ref name="Kregel_2013">{{cite journal | vauthors = Kregel S, Kiriluk KJ, Rosen AM, Cai Y, Reyes EE, Otto KB, Tom W, Paner GP, Szmulewitz RZ, Vander Griend DJ | title = Sox2 is an androgen receptor-repressed gene that promotes castration-resistant prostate cancer | journal = PLoS ONE | volume = 8 | issue = 1 | pages = e53701 | year = 2013 | pmid = 23326489 | pmc = 3543364 | doi = 10.1371/journal.pone.0053701 }}</ref>。

SOX2的異位表達與[[結直腸癌]]中的細胞異常分化有關<ref name="pmid17136346">{{cite journal | vauthors = Tani Y, Akiyama Y, Fukamachi H, Yanagihara K, Yuasa Y | title = Transcription factor SOX2 up-regulates stomach-specific pepsinogen A gene expression | journal = Journal of Cancer Research and Clinical Oncology | volume = 133 | issue = 4 | pages = 263–9 | date = April 2007 | pmid = 17136346 | doi = 10.1007/s00432-006-0165-x }}</ref>。另外，Sox2與乳腺癌對[[他莫昔芬]]的抗性有關<ref>{{cite journal | vauthors = Piva M, Domenici G, Iriondo O, Rábano M, Simões BM, Comaills V, Barredo I, López-Ruiz JA, Zabalza I, Kypta R, ((Vivanco Md)) | title = Sox2 promotes tamoxifen resistance in breast cancer cells | journal = EMBO Molecular Medicine | volume = 6 | issue = 1 | pages = 66–79 | date = January 2014 | pmid = 24178749 | doi = 10.1002/emmm.201303411 | pmc=3936493}}</ref>。

== 甲狀腺激素的調控==
Sox2啓動子的上游（即增強子區域）有三個[[甲狀腺激素]]應答元件（TRE），甲狀腺激素（T3）能通過這些區域下調Sox2的表達。在神經幹細胞的增殖遷移過程中，TRα1（一種甲狀腺激素的受體）的表達會上調。此現象提示甲狀腺激素能通過甲狀腺激素信號通路對Sox2進行轉錄抑制，促進神經幹細胞從腦室下區遷出並分化。人胚胎發育過程中甲狀腺激素的缺失，尤其是胚胎發育的頭三個月中的缺失，會造成中樞神經系統發育的異常。因此，可以得出結論，在胚胎發育中，甲狀腺激素水平低會造成神經性缺陷，諸如以發育不良爲特徵的[[呆小症]]<ref name="pmid22560077">{{cite journal | vauthors = López-Juárez A, Remaud S, Hassani Z, Jolivet P, Pierre Simons J, Sontag T, Yoshikawa K, Price J, Morvan-Dubois G, Demeneix BA | title = Thyroid hormone signaling acts as a neurogenic switch by repressing Sox2 in the adult neural stem cell niche | journal = Cell Stem Cell | volume = 10 | issue = 5 | pages = 531–43 | date = May 2012 | pmid = 22560077 | doi = 10.1016/j.stem.2012.04.008 }}</ref>。

== 相互作用 ==
Sox2能與{{Link-en|Pax6|Pax6}}、NPM1、Oct4之間發生[[蛋白質相互作用|相互作用]]<ref name="pmid12710953">{{cite journal | vauthors = Aota S, Nakajima N, Sakamoto R, Watanabe S, Ibaraki N, Okazaki K | title = Pax6 autoregulation mediated by direct interaction of Pax6 protein with the head surface ectoderm-specific enhancer of the mouse Pax6 gene | journal = Developmental Biology | volume = 257 | issue = 1 | pages = 1–13 | date = May 2003 | pmid = 12710953 | doi = 10.1016/S0012-1606(03)00058-7 }}</ref><ref name="pmid19571885" /><ref name="Chambers_Tomlinson_2009" />。已證明Sox2能與Oct3/4協同調控{{link-en|Rex1|Rex1}}的表達<ref name="pmid16714766">{{cite journal | vauthors = Shi W, Wang H, Pan G, Geng Y, Guo Y, Pei D | title = Regulation of the pluripotency marker Rex-1 by Nanog and Sox2 | url = https://archive.org/details/sim_journal-of-biological-chemistry_2006-08-18_281_33/page/23318 | journal = Journal of Biological Chemistry | volume = 281 | issue = 33 | pages = 23319–25 | date = August 2006 | pmid = 16714766 | doi = 10.1074/jbc.M601811200 }}</ref>。

== 參考 ==
{{reflist|2}}

== 拓展閱讀 ==
{{refbegin|35em}}

* {{cite journal | vauthors = Kamachi Y, Uchikawa M, Kondoh H | title = Pairing SOX off: with partners in the regulation of embryonic development | journal = Trends in Genetics | volume = 16 | issue = 4 | pages = 182–7 | date = April 2000 | pmid = 10729834 | doi = 10.1016/S0168-9525(99)01955-1 }}
* {{cite journal | vauthors = Schepers GE, Teasdale RD, Koopman P | title = Twenty pairs of sox: extent, homology, and nomenclature of the mouse and human sox transcription factor gene families | journal = Developmental Cell | volume = 3 | issue = 2 | pages = 167–70 | date = August 2002 | pmid = 12194848 | doi = 10.1016/S1534-5807(02)00223-X }}
* {{cite journal | vauthors = Hever AM, Williamson KA, van Heyningen V | title = Developmental malformations of the eye: the role of PAX6, SOX2 and OTX2 | journal = Clinical Genetics | volume = 69 | issue = 6 | pages = 459–70 | date = June 2006 | pmid = 16712695 | doi = 10.1111/j.1399-0004.2006.00619.x }}
* {{cite journal | vauthors = Yuan H, Corbi N, Basilico C, Dailey L | title = Developmental-specific activity of the FGF-4 enhancer requires the synergistic action of Sox2 and Oct-3 | url = https://archive.org/details/sim_genes-development_1995-11-01_9_21/page/2634 | journal = Genes & Development | volume = 9 | issue = 21 | pages = 2635–45 | date = November 1995 | pmid = 7590241 | doi = 10.1101/gad.9.21.2635 }}
* {{cite journal | vauthors = Stevanovic M, Zuffardi O, Collignon J, Lovell-Badge R, Goodfellow P | title = The cDNA sequence and chromosomal location of the human SOX2 gene | journal = Mammalian Genome | volume = 5 | issue = 10 | pages = 640–2 | date = October 1994 | pmid = 7849401 | doi = 10.1007/BF00411460 }}
* {{cite journal | vauthors = Bonaldo MF, Lennon G, Soares MB | title = Normalization and subtraction: two approaches to facilitate gene discovery | journal = Genome Research | volume = 6 | issue = 9 | pages = 791–806 | date = September 1996 | pmid = 8889548 | doi = 10.1101/gr.6.9.791 }}
* {{cite journal | vauthors = Helland R, Berglund GI, Otlewski J, Apostoluk W, Andersen OA, Willassen NP, Smalås AO | title = High-resolution structures of three new trypsin-squash-inhibitor complexes: a detailed comparison with other trypsins and their complexes | journal = Acta Crystallographica Section D | volume = 55 | issue = Pt 1 | pages = 139–48 | date = January 1999 | pmid = 10089404 | doi = 10.1107/S090744499801052X }}
* {{cite journal | vauthors = Güre AO, Stockert E, Scanlan MJ, Keresztes RS, Jäger D, Altorki NK, Old LJ, Chen YT | title = Serological identification of embryonic neural proteins as highly immunogenic tumor antigens in small cell lung cancer | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 97 | issue = 8 | pages = 4198–203 | date = April 2000 | pmid = 10760287 | pmc = 18195 | doi = 10.1073/pnas.97.8.4198 }}
* {{cite journal | vauthors = Ambrosetti DC, Schöler HR, Dailey L, Basilico C | title = Modulation of the activity of multiple transcriptional activation domains by the DNA binding domains mediates the synergistic action of Sox2 and Oct-3 on the fibroblast growth factor-4 enhancer | url = https://archive.org/details/sim_journal-of-biological-chemistry_2000-07-28_275_30/page/23386 | journal = The Journal of Biological Chemistry | volume = 275 | issue = 30 | pages = 23387–97 | date = July 2000 | pmid = 10801796 | doi = 10.1074/jbc.M000932200 }}
* {{cite journal | vauthors = Kamachi Y, Uchikawa M, Tanouchi A, Sekido R, Kondoh H | title = Pax6 and SOX2 form a co-DNA-binding partner complex that regulates initiation of lens development | url = https://archive.org/details/sim_genes-development_2001-05-15_15_10/page/1272 | journal = Genes & Development | volume = 15 | issue = 10 | pages = 1272–86 | date = May 2001 | pmid = 11358870 | pmc = 313803 | doi = 10.1101/gad.887101 }}
* {{cite journal | vauthors = Fantes J, Ragge NK, Lynch SA, McGill NI, Collin JR, Howard-Peebles PN, Hayward C, Vivian AJ, Williamson K, van Heyningen V, FitzPatrick DR | title = Mutations in SOX2 cause anophthalmia | journal = Nature Genetics | volume = 33 | issue = 4 | pages = 461–3 | date = April 2003 | pmid = 12612584 | doi = 10.1038/ng1120 }}
* {{cite journal | vauthors = Wiebe MS, Nowling TK, Rizzino A | title = Identification of novel domains within Sox-2 and Sox-11 involved in autoinhibition of DNA binding and partnership specificity | url = https://archive.org/details/sim_journal-of-biological-chemistry_2003-05-16_278_20/page/17900 | journal = Journal of Biological Chemistry | volume = 278 | issue = 20 | pages = 17901–11 | date = May 2003 | pmid = 12637543 | doi = 10.1074/jbc.M212211200 }}
* {{cite journal | vauthors = Aota S, Nakajima N, Sakamoto R, Watanabe S, Ibaraki N, Okazaki K | title = Pax6 autoregulation mediated by direct interaction of Pax6 protein with the head surface ectoderm-specific enhancer of the mouse Pax6 gene | journal = Developmental Biology | volume = 257 | issue = 1 | pages = 1–13 | date = May 2003 | pmid = 12710953 | doi = 10.1016/S0012-1606(03)00058-7 }}
* {{cite journal | vauthors = Schepers G, Wilson M, Wilhelm D, Koopman P | title = SOX8 is expressed during testis differentiation in mice and synergizes with SF1 to activate the Amh promoter in vitro | url = https://archive.org/details/sim_journal-of-biological-chemistry_2003-07-25_278_30/page/28100 | journal = Journal of Biological Chemistry | volume = 278 | issue = 30 | pages = 28101–8 | date = July 2003 | pmid = 12732652 | doi = 10.1074/jbc.M304067200 }}
* {{cite journal | vauthors = Reményi A, Lins K, Nissen LJ, Reinbold R, Schöler HR, Wilmanns M | title = Crystal structure of a POU/HMG/DNA ternary complex suggests differential assembly of Oct4 and Sox2 on two enhancers | url = https://archive.org/details/sim_genes-development_2003-08-15_17_16/page/2048 | journal = Genes & Development | volume = 17 | issue = 16 | pages = 2048–59 | date = August 2003 | pmid = 12923055 | pmc = 196258 | doi = 10.1101/gad.269303 }}
* {{cite journal | vauthors = Williams DC, Cai M, Clore GM | title = Molecular basis for synergistic transcriptional activation by Oct1 and Sox2 revealed from the solution structure of the 42-kDa Oct1.Sox2.Hoxb1-DNA ternary transcription factor complex | url = https://archive.org/details/sim_journal-of-biological-chemistry_2004-01-09_279_2/page/1448 | journal = Journal of Biological Chemistry | volume = 279 | issue = 2 | pages = 1449–57 | date = January 2004 | pmid = 14559893 | doi = 10.1074/jbc.M309790200 }}
* {{cite journal | vauthors = Tsukamoto T, Inada K, Tanaka H, Mizoshita T, Mihara M, Ushijima T, Yamamura Y, Nakamura S, Tatematsu M | title = Down-regulation of a gastric transcription factor, Sox2, and ectopic expression of intestinal homeobox genes, Cdx1 and Cdx2: inverse correlation during progression from gastric/intestinal-mixed to complete intestinal metaplasia | journal = Journal of Cancer Research and Clinical Oncology | volume = 130 | issue = 3 | pages = 135–45 | date = March 2004 | pmid = 14655050 | doi = 10.1007/s00432-003-0519-6 }}
{{refend}}

== 外部連結 ==
* [https://web.archive.org/web/20090628185523/http://jura.wi.mit.edu/young_public/hESregulation/index.html Young Lab- Core Transcriptional Regulatory Circuitry in Human Embryonic Stem Cells]
* [http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=gene&part=sox2 GeneReviews/NCBI/NIH/UW entry on SOX2-related eye disorders]{{Wayback|url=http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=gene&part=sox2 |date=20100304112643 }}
* [http://www.jove.com/index/details.stp?ID=734 Generating iPS Cells from MEFS through Forced Expression of Sox-2, Oct-4, c-Myc, and Klf4 (''Journal of Visualized Experiments'')]{{Wayback|url=http://www.jove.com/index/details.stp?ID=734 |date=20080409111706 }}
* [http://www.ncbi.nlm.nih.gov/books/NBK1378/ GeneReviews/NCBI/NIH/UW entry on Anophthalmia / Microphthalmia Overview]{{Wayback|url=http://www.ncbi.nlm.nih.gov/books/NBK1378/ |date=20170118124532 }}

{{PDB Gallery|geneid=6657}}
{{Transcription factors|g4}}

[[Category:轉錄因子]]
[[Category:幹細胞]]

SOX2 - 版本历史

2026年1月24日 (六) 11:37 imported>曦城星月