<?xml version="1.0"?>
<feed xmlns="http://www.w3.org/2005/Atom" xml:lang="zh">
	<id>https://arolstar52-zhtest.hf.space/index.php?action=history&amp;feed=atom&amp;title=SNAPC4</id>
	<title>SNAPC4 - 版本历史</title>
	<link rel="self" type="application/atom+xml" href="https://arolstar52-zhtest.hf.space/index.php?action=history&amp;feed=atom&amp;title=SNAPC4"/>
	<link rel="alternate" type="text/html" href="https://arolstar52-zhtest.hf.space/index.php?title=SNAPC4&amp;action=history"/>
	<updated>2026-07-09T20:03:25Z</updated>
	<subtitle>本wiki上该页面的版本历史</subtitle>
	<generator>MediaWiki 1.43.9</generator>
	<entry>
		<id>https://arolstar52-zhtest.hf.space/index.php?title=SNAPC4&amp;diff=2282240&amp;oldid=prev</id>
		<title>imported&gt;InternetArchiveBot：​Add 8 books for verifiability (20251017sim)) #IABot (v2.0.9.5) (GreenC bot</title>
		<link rel="alternate" type="text/html" href="https://arolstar52-zhtest.hf.space/index.php?title=SNAPC4&amp;diff=2282240&amp;oldid=prev"/>
		<updated>2025-10-18T04:42:58Z</updated>

		<summary type="html">&lt;p&gt;Add 8 books for verifiability (20251017sim)) #IABot (v2.0.9.5) (&lt;a href=&quot;/index.php?title=User:GreenC_bot&amp;amp;action=edit&amp;amp;redlink=1&quot; class=&quot;new&quot; title=&quot;User:GreenC bot（页面不存在）&quot;&gt;GreenC bot&lt;/a&gt;&lt;/p&gt;
&lt;p&gt;&lt;b&gt;新页面&lt;/b&gt;&lt;/p&gt;&lt;div&gt;{{Infobox_gene}}&lt;br /&gt;
&amp;#039;&amp;#039;&amp;#039;snRNA激活蛋白复合体第四亚基&amp;#039;&amp;#039;&amp;#039;（{{langx|en|&amp;#039;&amp;#039;&amp;#039;snRNA-activating protein complex subunit 4&amp;#039;&amp;#039;&amp;#039;}}）是一个由人类[[基因]] &amp;#039;&amp;#039;SNAPC4&amp;#039;&amp;#039; 编码的[[蛋白质]]&amp;lt;ref name=&amp;quot;pmid9418884&amp;quot;&amp;gt;{{cite journal | author = Wong MW, Henry RW, Ma B, Kobayashi R, Klages N, Matthias P, Strubin M, Hernandez N | title = The Large Subunit of Basal Transcription Factor SNAPc Is a Myb Domain Protein That Interacts with Oct-1 | url = https://archive.org/details/sim_molecular-and-cellular-biology_1998-01_18_1/page/368 | journal = Mol Cell Biol | volume = 18 | issue = 1 | pages = 368–77 | pmid = 9418884 | pmc = 121507 | doi =  |date=January 1998}}&amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;entrez&amp;quot;&amp;gt;{{Cite web| title = Entrez Gene: SNAPC4 small nuclear RNA activating complex, polypeptide 4, 190kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=6621| accessdate = }}&amp;lt;/ref&amp;gt;。化学式为&amp;lt;ref&amp;gt;{{Cite web |title=Expasy - ProtParam |url=https://web.expasy.org/cgi-bin/protparam/protparam_bis.cgi?Q5SXM2@1-1469@ |website=web.expasy.org |access-date=2025-06-01}}&amp;lt;/ref&amp;gt;：C&amp;lt;sub&amp;gt;6962&amp;lt;/sub&amp;gt;H&amp;lt;sub&amp;gt;11203&amp;lt;/sub&amp;gt;O&amp;lt;sub&amp;gt;2158&amp;lt;/sub&amp;gt;N&amp;lt;sub&amp;gt;2075&amp;lt;/sub&amp;gt;S&amp;lt;sub&amp;gt;29&amp;lt;/sub&amp;gt;&amp;lt;ref&amp;gt;{{Cite web |title=UniProt |url=https://www.uniprot.org/uniprotkb/Q5SXM2/entry |website=UniProt |language=en |access-date=2025-06-01}}&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
&amp;lt;!-- 这块留到以后再译好了 &lt;br /&gt;
==Model organisms==&lt;br /&gt;
{| class=&amp;quot;wikitable sortable collapsible collapsed&amp;quot; border=&amp;quot;1&amp;quot; cellpadding=&amp;quot;2&amp;quot; style=&amp;quot;float: right;&amp;quot; |&lt;br /&gt;
|+ &amp;#039;&amp;#039;Snapc4&amp;#039;&amp;#039; knockout mouse phenotype&lt;br /&gt;
|-&lt;br /&gt;
! Characteristic!! Phenotype&lt;br /&gt;
&lt;br /&gt;
|-&lt;br /&gt;
| [[Homozygote]] viability || bgcolor=&amp;quot;#C40000&amp;quot;|Abnormal&lt;br /&gt;
|-&lt;br /&gt;
| [[Recessive]] lethal study || bgcolor=&amp;quot;#C40000&amp;quot;|Abnormal&lt;br /&gt;
|-&lt;br /&gt;
| Fertility || bgcolor=&amp;quot;#488ED3&amp;quot;|Normal&lt;br /&gt;
|-&lt;br /&gt;
| Body weight || bgcolor=&amp;quot;#488ED3&amp;quot;|Normal&lt;br /&gt;
|-&lt;br /&gt;
| [[Open Field (animal test)|Anxiety]] || bgcolor=&amp;quot;#488ED3&amp;quot;|Normal&lt;br /&gt;
|-&lt;br /&gt;
| Neurological assessment || bgcolor=&amp;quot;#488ED3&amp;quot;|Normal&lt;br /&gt;
|-&lt;br /&gt;
| Grip strength || bgcolor=&amp;quot;#488ED3&amp;quot;|Normal&lt;br /&gt;
|-&lt;br /&gt;
| [[Hot plate test|Hot plate]] || bgcolor=&amp;quot;#488ED3&amp;quot;|Normal&lt;br /&gt;
|-&lt;br /&gt;
| [[Dysmorphology]] || bgcolor=&amp;quot;#488ED3&amp;quot;|Normal&lt;br /&gt;
|-&lt;br /&gt;
| [[Indirect calorimetry]] || bgcolor=&amp;quot;#488ED3&amp;quot;|Normal&lt;br /&gt;
|-&lt;br /&gt;
| [[Glucose tolerance test]] || bgcolor=&amp;quot;#488ED3&amp;quot;|Normal&lt;br /&gt;
|-&lt;br /&gt;
| [[Auditory brainstem response]] || bgcolor=&amp;quot;#488ED3&amp;quot;|Normal&lt;br /&gt;
|-&lt;br /&gt;
| [[Dual-energy X-ray absorptiometry|DEXA]] || bgcolor=&amp;quot;#488ED3&amp;quot;|Normal&lt;br /&gt;
|-&lt;br /&gt;
| [[Radiography]] || bgcolor=&amp;quot;#488ED3&amp;quot;|Normal&lt;br /&gt;
|-&lt;br /&gt;
| Body temperature || bgcolor=&amp;quot;#488ED3&amp;quot;|Normal&lt;br /&gt;
|-&lt;br /&gt;
| Eye morphology || bgcolor=&amp;quot;#488ED3&amp;quot;|Normal&lt;br /&gt;
|-&lt;br /&gt;
| [[Clinical chemistry]] || bgcolor=&amp;quot;#488ED3&amp;quot;|Normal&lt;br /&gt;
|-&lt;br /&gt;
| [[Blood plasma|Plasma]] [[immunoglobulin]]s || bgcolor=&amp;quot;#488ED3&amp;quot;|Normal&lt;br /&gt;
|-&lt;br /&gt;
| [[Haematology]] || bgcolor=&amp;quot;#488ED3&amp;quot;|Normal&lt;br /&gt;
|-&lt;br /&gt;
| [[Peripheral blood lymphocyte]]s || bgcolor=&amp;quot;#488ED3&amp;quot;|Normal&lt;br /&gt;
|-&lt;br /&gt;
| [[Micronucleus test]] || bgcolor=&amp;quot;#488ED3&amp;quot;|Normal&lt;br /&gt;
|-&lt;br /&gt;
| Heart weight || bgcolor=&amp;quot;#488ED3&amp;quot;|Normal&lt;br /&gt;
|-&lt;br /&gt;
| Skin Histopathology || bgcolor=&amp;quot;#488ED3&amp;quot;|Normal&lt;br /&gt;
|-&lt;br /&gt;
| Brain histopathology || bgcolor=&amp;quot;#488ED3&amp;quot;|Normal&lt;br /&gt;
|-&lt;br /&gt;
| &amp;#039;&amp;#039;[[Salmonella]]&amp;#039;&amp;#039; infection || bgcolor=&amp;quot;#488ED3&amp;quot;|Normal&amp;lt;ref name=&amp;quot;&amp;#039;&amp;#039;Salmonella&amp;#039;&amp;#039; infection&amp;quot;&amp;gt;{{cite web |url=http://www.sanger.ac.uk/mouseportal/phenotyping/MBEZ/salmonella-challenge/ |title=&amp;#039;&amp;#039;Salmonella&amp;#039;&amp;#039; infection data for Snapc4 |publisher=Wellcome Trust Sanger Institute}}&amp;lt;/ref&amp;gt;&lt;br /&gt;
|-&lt;br /&gt;
| &amp;#039;&amp;#039;[[Citrobacter]]&amp;#039;&amp;#039; infection || bgcolor=&amp;quot;#488ED3&amp;quot;|Normal&amp;lt;ref name=&amp;quot;&amp;#039;&amp;#039;Citrobacter&amp;#039;&amp;#039; infection&amp;quot;&amp;gt;{{cite web |url=http://www.sanger.ac.uk/mouseportal/phenotyping/MBEZ/citrobacter-challenge/ |title=&amp;#039;&amp;#039;Citrobacter&amp;#039;&amp;#039; infection data for Snapc4 |publisher=Wellcome Trust Sanger Institute}}&amp;lt;/ref&amp;gt;&lt;br /&gt;
|-&lt;br /&gt;
| colspan=2; style=&amp;quot;text-align: center;&amp;quot; | All tests and analysis from&amp;lt;ref name=&amp;quot;mgp_reference&amp;quot;&amp;gt;{{cite journal| doi = 10.1111/j.1755-3768.2010.4142.x| title = The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice| year = 2010| author = Gerdin AK| journal = Acta Ophthalmologica| volume = 88| issue = S248 }}&amp;lt;/ref&amp;gt;&amp;lt;ref&amp;gt;[http://www.sanger.ac.uk/mouseportal/ Mouse Resources Portal], Wellcome Trust Sanger Institute.&amp;lt;/ref&amp;gt;&lt;br /&gt;
|}&lt;br /&gt;
[[Model organism]]s have been used in the study of SNAPC4 function. A conditional [[knockout mouse]] line, called &amp;#039;&amp;#039;Snapc4&amp;lt;sup&amp;gt;tm1a(KOMP)Wtsi&amp;lt;/sup&amp;gt;&amp;#039;&amp;#039;&amp;lt;ref name=&amp;quot;allele_ref&amp;quot;&amp;gt;{{cite web |url=http://www.knockoutmouse.org/martsearch/search?query=Snapc4 |title=International Knockout Mouse Consortium}}&amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;mgi_allele_ref&amp;quot;&amp;gt;{{cite web |url=http://www.informatics.jax.org/searchtool/Search.do?query=MGI:4362491 |title=Mouse Genome Informatics}}&amp;lt;/ref&amp;gt; was generated as part of the [[International Knockout Mouse Consortium]] program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists — at the [[Wellcome Trust Sanger Institute]].&amp;lt;ref name=&amp;quot;pmid21677750&amp;quot;&amp;gt;{{Cite pmid|21677750}}&amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;mouse_library&amp;quot;&amp;gt;{{cite journal |author=Dolgin E |title=Mouse library set to be knockout |url=https://archive.org/details/sim_nature-uk_2011-06-16_474_7351/page/262 |journal=Nature |volume=474 |issue=7351 |pages=262–3 |year=2011 |month=June |pmid=21677718 |doi=10.1038/474262a }}&amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;mouse_for_all_reasons&amp;quot;&amp;gt;{{cite journal |author=Collins FS, Rossant J, Wurst W |title=A mouse for all reasons |journal=Cell |volume=128 |issue=1 |pages=9–13 |year=2007 |month=January |pmid=17218247 |doi=10.1016/j.cell.2006.12.018 }}&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
Male and female animals underwent a standardized [[phenotypic screen]] to determine the effects of deletion.&amp;lt;ref name=&amp;quot;mgp_reference&amp;quot; /&amp;gt;&amp;lt;ref name=&amp;quot;pmid21722353&amp;quot;&amp;gt;{{cite journal| author=van der Weyden L, White JK, Adams DJ, Logan DW| title=The mouse genetics toolkit: revealing function and mechanism. | journal=Genome Biol | year= 2011 | volume= 12 | issue= 6 | pages= 224 | pmid=21722353 | doi=10.1186/gb-2011-12-6-224  | pmc=3218837}}&amp;lt;/ref&amp;gt; Twenty six tests were carried out on [[mutant]] mice and two significant abnormalities were observed. No [[homozygous]] mutant embryos were recorded during gestation and, in a separate study, no homozygous animals were observed at [[weaning]]. The remaining tests were carried out on adult [[heterozygous]] mutant animals and no further abnormalities were observed.&amp;lt;ref name=&amp;quot;mgp_reference&amp;quot; /&amp;gt;&lt;br /&gt;
--&amp;gt;&lt;br /&gt;
&lt;br /&gt;
==相互作用==&lt;br /&gt;
SNAPC4能与[[SNAPC1]]&amp;lt;ref name=pmid11056176&amp;gt;{{cite journal |last=Ma |first=B |authorlink= |coauthors=Hernandez N |title=A map of protein-protein contacts within the small nuclear RNA-activating protein complex SNAPc |journal=J. Biol. Chem. |volume=276 |issue=7 |pages=5027–35 |publisher= |location = United States| issn = 0021-9258| pmid = 11056176 |doi = 10.1074/jbc.M009301200 | bibcode = | oclc =| id = | url =https://archive.org/details/sim_journal-of-biological-chemistry_2001-02-16_276_7/page/5026| language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |date=February 2001}}&amp;lt;/ref&amp;gt;、[[POU2F1]]&amp;lt;ref name=pmid9418884&amp;gt;{{cite journal |last=Wong |first=M W |authorlink= |coauthors=Henry R W, Ma B, Kobayashi R, Klages N, Matthias P, Strubin M, Hernandez N |title=The Large Subunit of Basal Transcription Factor SNAPc Is a Myb Domain Protein That Interacts with Oct-1 |journal=Mol. Cell. Biol. |volume=18 |issue=1 |pages=368–77 |publisher= |location = UNITED STATES| issn = 0270-7306| pmid = 9418884 | bibcode = | oclc =| id = | url =https://archive.org/details/sim_molecular-and-cellular-biology_1998-01_18_1/page/368| language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=121507 |date=January 1998}}&amp;lt;/ref&amp;gt;&amp;lt;ref name=pmid11856838&amp;gt;{{cite journal |last=Hovde |first=Stacy |authorlink= |coauthors=Brooks Aimee, Strong Katie, Geiger James H |title=Crystallization of the Oct-1/SNAP190 peptide/DNA complex |journal=Acta Crystallogr. D Biol. Crystallogr. |volume=58 |issue=Pt 3 |pages=511–2 |publisher= |location = Denmark| issn = 0907-4449| pmid = 11856838 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1107/S0907444901021461 |date=March 2002}}&amp;lt;/ref&amp;gt;和[[SNAPC2]]&amp;lt;ref name=pmid9418884/&amp;gt;&amp;lt;ref name=pmid11056176/&amp;gt;[[蛋白質交互作用|相互作用]]。&lt;br /&gt;
&lt;br /&gt;
==参考文献==&lt;br /&gt;
{{Reflist}}&lt;br /&gt;
&lt;br /&gt;
==延伸阅读==&lt;br /&gt;
{{Refbegin| 2}}&lt;br /&gt;
{{PBB Further reading&lt;br /&gt;
| citations =&lt;br /&gt;
*{{Cite journal  | author=Henry RW, Sadowski CL, Kobayashi R, Hernandez N |title=A TBP-TAF complex required for transcription of human snRNA genes by RNA polymerase II and III | url=https://archive.org/details/sim_nature-uk_1995-04-13_374_6523/page/652 |journal=Nature |volume=374 |issue= 6523 |pages= 653–6 |year= 1995 |pmid= 7715707 |doi= 10.1038/374653a0 }}&lt;br /&gt;
*{{Cite journal  | author=Ma B, Hernandez N |title=A map of protein-protein contacts within the small nuclear RNA-activating protein complex SNAPc | url=https://archive.org/details/sim_journal-of-biological-chemistry_2001-02-16_276_7/page/5026 |journal=J. Biol. Chem. |volume=276 |issue= 7 |pages= 5027–35 |year= 2001 |pmid= 11056176 |doi= 10.1074/jbc.M009301200 }}&lt;br /&gt;
*{{Cite journal  | author=Hovde S, Brooks A, Strong K, Geiger JH |title=Crystallization of the Oct-1/SNAP190 peptide/DNA complex |journal=Acta Crystallogr. D Biol. Crystallogr. |volume=58 |issue= Pt 3 |pages= 511–2 |year= 2002 |pmid= 11856838 |doi=10.1107/S0907444901021461  }}&lt;br /&gt;
*{{Cite journal  | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 | author2=Feingold EA  | author3=Grouse LH  | display-authors=3  | last4=Derge  | first4=JG  | last5=Klausner  | first5=RD  | last6=Collins  | first6=FS  | last7=Wagner  | first7=L  | last8=Shenmen  | first8=CM  | last9=Schuler  | first9=GD }}&lt;br /&gt;
*{{Cite journal  | author=Hinkley CS |title=The small nuclear RNA-activating protein 190 Myb DNA binding domain stimulates TATA box-binding protein-TATA box recognition | url=https://archive.org/details/sim_journal-of-biological-chemistry_2003-05-16_278_20/page/18648 |journal=J. Biol. Chem. |volume=278 |issue= 20 |pages= 18649–57 |year= 2003 |pmid= 12621023 |doi= 10.1074/jbc.M204247200 | author2=Hirsch HA  | author3=Gu L  | display-authors=3  | last4=Lamere  | first4=B  | last5=Henry  | first5=RW }}&lt;br /&gt;
*{{Cite journal  | author=Ota T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 | author2=Suzuki Y  | author3=Nishikawa T  | display-authors=3  | last4=Otsuki  | first4=Tetsuji  | last5=Sugiyama  | first5=Tomoyasu  | last6=Irie  | first6=Ryotaro  | last7=Wakamatsu  | first7=Ai  | last8=Hayashi  | first8=Koji  | last9=Sato  | first9=Hiroyuki }}&lt;br /&gt;
*{{Cite journal  | author=Humphray SJ |title=DNA sequence and analysis of human chromosome 9 | url=https://archive.org/details/sim_nature-uk_2004-05-27_429_6990/page/368 |journal=Nature |volume=429 |issue= 6990 |pages= 369–74 |year= 2004 |pmid= 15164053 |doi= 10.1038/nature02465  | pmc=2734081 | author2=Oliver K  | author3=Hunt AR  | display-authors=3  | last4=Plumb  | first4=R. W.  | last5=Loveland  | first5=J. E.  | last6=Howe  | first6=K. L.  | last7=Andrews  | first7=T. D.  | last8=Searle  | first8=S.  | last9=Hunt  | first9=S. E. }}&lt;br /&gt;
*{{Cite journal  | author=Beausoleil SA |title=Large-scale characterization of HeLa cell nuclear phosphoproteins |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130–5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101  | pmc=514446 | author2=Jedrychowski M  | author3=Schwartz D  | display-authors=3  | last4=Elias  | first4=JE  | last5=Villén  | first5=J  | last6=Li  | first6=J  | last7=Cohn  | first7=MA  | last8=Cantley  | first8=LC  | last9=Gygi  | first9=SP }}&lt;br /&gt;
*{{Cite journal  | author=Gu L, Esselman WJ, Henry RW |title=Cooperation between small nuclear RNA-activating protein complex (SNAPC) and TATA-box-binding protein antagonizes protein kinase CK2 inhibition of DNA binding by SNAPC | url=https://archive.org/details/sim_journal-of-biological-chemistry_2005-07-29_280_30/page/27696 |journal=J. Biol. Chem. |volume=280 |issue= 30 |pages= 27697–704 |year= 2005 |pmid= 15955816 |doi= 10.1074/jbc.M503206200 }}&lt;br /&gt;
*{{Cite journal  | author=Gu L, Husain-Ponnampalam R, Hoffmann-Benning S, Henry RW |title=The protein kinase CK2 phosphorylates SNAP190 to negatively regulate SNAPC DNA binding and human U6 transcription by RNA polymerase III | url=https://archive.org/details/sim_journal-of-biological-chemistry_2007-09-21_282_38/page/27886 |journal=J. Biol. Chem. |volume=282 |issue= 38 |pages= 27887–96 |year= 2007 |pmid= 17670747 |doi= 10.1074/jbc.M702269200 }}&lt;br /&gt;
}}&lt;br /&gt;
{{Refend}}&lt;br /&gt;
&lt;br /&gt;
&amp;lt;!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. --&amp;gt;&lt;br /&gt;
{{PBB Controls&lt;br /&gt;
| update_page = yes&lt;br /&gt;
| require_manual_inspection = no&lt;br /&gt;
| update_protein_box = yes&lt;br /&gt;
| update_summary = yes&lt;br /&gt;
| update_citations = yes&lt;br /&gt;
}}&lt;/div&gt;</summary>
		<author><name>imported&gt;InternetArchiveBot</name></author>
	</entry>
</feed>