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SIRT1 - 版本历史
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'''SIRT1'''（{{langx|en|Sirtuin 1}}），也被称为 '''NAD-依赖性去乙酰化酶Sirtuin-1'''（{{langx|en|NAD-dependent deacetylase sirtuin-1}}），是人类基因组中由SIRT1[[基因]]编码的[[蛋白质|蛋白]]。人的SIRT1基因位于[[10号染色体]]上。SIRT1的功能是去除蛋白质上的乙酰基团（去乙酰化）。SIRT1的去乙酰化功能在一些生物学过程中有发挥一定的作用<ref name="pmid10381378">{{Cite journal|title=Characterization of five human cDNAs with homology to the yeast SIR2 gene: Sir2-like proteins (sirtuins) metabolize NAD and may have protein ADP-ribosyltransferase activity|url=https://pubmed.ncbi.nlm.nih.gov/10381378|last=Frye|first=R. A.|date=1999-06-24|journal=Biochemical and Biophysical Research Communications|issue=1|doi=10.1006/bbrc.1999.0897|volume=260|pages=273–279|issn=0006-291X|pmid=10381378|access-date=2021-11-10|archive-date=2021-11-10|archive-url=https://web.archive.org/web/20211110165950/https://pubmed.ncbi.nlm.nih.gov/10381378/|dead-url=no}}</ref><ref name="entrez">{{Cite web|title=SIRT1 sirtuin 1 [Homo sapiens (human)] - Gene - NCBI|url=https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=23411|access-date=2021-11-10|work=www.ncbi.nlm.nih.gov|archive-date=2021-11-10|archive-url=https://web.archive.org/web/20211110124857/https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=23411|dead-url=no}}</ref><ref name="UCSC_SIRT1">{{UCSC genome browser|SIRT1}}</ref>。<br />
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== 参考文献 ==<br />
{{reflist}}<br />
== 外部链接 ==<br />
* [https://web.archive.org/web/20071202143228/http://www.corante.com/pipeline/archives/2005/11/20/sir2_surprise.php Corante weblog] by [[Derek Lowe (chemist)|Derek Lowe]] about sir2 and SIRT1 research.<br />
{{碳-氮非肽水解酶类}}<br />
{{biochem-stub}}<br />
[[Category:作用于非肽碳-氮键的水解酶]]<br />
[[Category:位於10號人類染色體的基因]]</div>
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