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'''成对两亲性螺旋蛋白SIN3B'''（{{langx|en|Paired amphipathic helix protein Sin3b}}）化学式为：C<sub>5908</sub>H<sub>9212</sub>O<sub>1772</sub>N<sub>1660</sub>S<sub>38</sub><ref>{{Cite web |title=Expasy - ProtParam |url=https://web.expasy.org/cgi-bin/protparam/protparam_bis.cgi?O75182@1-1162@ |website=web.expasy.org |access-date=2026-02-10}}</ref>，是一个由人类[[基因]]''SIN3B''编码的[[蛋白质]]<ref name="pmid9734811">{{cite journal | author = Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O | title = Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro | journal = DNA Res | volume = 5 | issue = 3 | pages = 169–76 | pmid = 9734811 | pmc = | doi =10.1093/dnares/5.3.169 |date=December 1998}}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SIN3B SIN3 homolog B, transcription regulator (yeast)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23309| accessdate = }}</ref>。<br />
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==互作==<br />
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SIN3B与[[HDAC1]]<ref name=pmid10444591>{{cite journal |last=Zhang |first=Y |authorlink= |coauthors=Ng H H, Erdjument-Bromage H, Tempst P, Bird A, Reinberg D |title=Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation |journal=Genes Dev. |volume=13 |issue=15 |pages=1924–35 |publisher= |location = UNITED STATES| issn = 0890-9369| pmid = 10444591 | bibcode = | oclc =| id = | url =https://archive.org/details/sim_genes-development_1999-08-01_13_15/page/1924| language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1101/gad.13.15.1924 |pmc=316920 |date=August 1999}}</ref><ref name=pmid10357820>{{cite journal |last=Koipally |first=J |authorlink= |coauthors=Renold A, Kim J, Georgopoulos K |title=Repression by Ikaros and Aiolos is mediated through histone deacetylase complexes |journal=EMBO J. |volume=18 |issue=11 |pages=3090–100 |publisher= |location = ENGLAND| issn = 0261-4189| pmid = 10357820 |doi = 10.1093/emboj/18.11.3090 | bibcode = | oclc =| id = | url =https://archive.org/details/sim_embo-journal_1999-06-01_18_11/page/3090| language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=1171390 |date=June 1999}}</ref>、[[Zinc finger and BTB domain-containing protein 16]]<ref name=pmid9627120>{{cite journal |last=David |first=G |authorlink= |coauthors=Alland L, Hong S H, Wong C W, DePinho R A, Dejean A |title=Histone deacetylase associated with mSin3A mediates repression by the acute promyelocytic leukemia-associated PLZF protein |journal=Oncogene |volume=16 |issue=19 |pages=2549–56 |publisher= |location = ENGLAND| issn = 0950-9232| pmid = 9627120 |doi = 10.1038/sj.onc.1202043 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |date=May 1998}}</ref>、[[SUDS3]]<ref name=pmid11909966>{{cite journal |last=Alland |first=Leila |authorlink= |coauthors=David Gregory, Shen-Li Hong, Potes Jason, Muhle Rebecca, Lee Hye-Chun, Hou Harry, Chen Ken, DePinho Ronald A |title=Identification of Mammalian Sds3 as an Integral Component of the Sin3/Histone Deacetylase Corepressor Complex |journal=Mol. Cell. Biol. |volume=22 |issue=8 |pages=2743–50 |publisher= |location = United States| issn = 0270-7306| pmid = 11909966 | bibcode = | oclc =| id = | url =https://archive.org/details/sim_molecular-and-cellular-biology_2002-04_22_8/page/2743| language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1128/MCB.22.8.2743-2750.2002 |pmc=133736 |date=April 2002}}</ref>以及[[IKZF1]]<ref name=pmid10357820/><ref name=pmid12015313>{{cite journal |last=Koipally |first=Joseph |authorlink= |coauthors=Georgopoulos Katia |title=A molecular dissection of the repression circuitry of Ikaros |journal=J. Biol. Chem. |volume=277 |issue=31 |pages=27697–705 |publisher= |location = United States| issn = 0021-9258| pmid = 12015313 |doi = 10.1074/jbc.M201694200 | bibcode = | oclc =| id = | url =https://archive.org/details/sim_journal-of-biological-chemistry_2002-08-02_277_31/page/27696| language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |date=August 2002}}</ref>等蛋白有[[蛋白質交互作用|相互作用]]。<br />
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==另见==<br />
* [[Transcription coregulator]]<br />
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==参考文献==<br />
{{reflist}}<br />
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==延伸阅读==<br />
{{refbegin | 2}}<br />
{{PBB Further reading <br />
| citations = <br />
*{{cite journal | author=Ayer DE, Lawrence QA, Eisenman RN |title=Mad-Max transcriptional repression is mediated by ternary complex formation with mammalian homologs of yeast repressor Sin3 |journal=Cell |volume=80 |issue= 5 |pages= 767–76 |year= 1995 |pmid= 7889570 |doi=10.1016/0092-8674(95)90355-0 }}<br />
*{{cite journal | author=David G, Alland L, Hong SH, ''et al.'' |title=Histone deacetylase associated with mSin3A mediates repression by the acute promyelocytic leukemia-associated PLZF protein |journal=Oncogene |volume=16 |issue= 19 |pages= 2549–56 |year= 1998 |pmid= 9627120 |doi= 10.1038/sj.onc.1202043 }}<br />
*{{cite journal | author=Koipally J, Renold A, Kim J, Georgopoulos K |title=Repression by Ikaros and Aiolos is mediated through histone deacetylase complexes | url=https://archive.org/details/sim_embo-journal_1999-06-01_18_11/page/3090 |journal=EMBO J. |volume=18 |issue= 11 |pages= 3090–100 |year= 1999 |pmid= 10357820 |doi= 10.1093/emboj/18.11.3090 | pmc=1171390 }}<br />
*{{cite journal | author=Naruse Y, Aoki T, Kojima T, Mori N |title=Neural restrictive silencer factor recruits mSin3 and histone deacetylase complex to repress neuron-specific target genes |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 24 |pages= 13691–6 |year= 2000 |pmid= 10570134 |doi=10.1073/pnas.96.24.13691 | pmc=24126 }}<br />
*{{cite journal | author=Spronk CA, Tessari M, Kaan AM, ''et al.'' |title=The Mad1-Sin3B interaction involves a novel helical fold |journal=Nat. Struct. Biol. |volume=7 |issue= 12 |pages= 1100–4 |year= 2001 |pmid= 11101889 |doi= 10.1038/81944 }}<br />
*{{cite journal | author=Spronk CA, Jansen JF, Tessari M, ''et al.'' |title=Sequence-specific assignment of the PAH2 domain of Sin3B free and bound to Mad1 |journal=J. Biomol. NMR |volume=19 |issue= 4 |pages= 377–8 |year= 2001 |pmid= 11370785 |doi=10.1023/A:1011262214741 }}<br />
*{{cite journal | author=Alland L, David G, Shen-Li H, ''et al.'' |title=Identification of Mammalian Sds3 as an Integral Component of the Sin3/Histone Deacetylase Corepressor Complex | url=https://archive.org/details/sim_molecular-and-cellular-biology_2002-04_22_8/page/2743 |journal=Mol. Cell. Biol. |volume=22 |issue= 8 |pages= 2743–50 |year= 2002 |pmid= 11909966 |doi=10.1128/MCB.22.8.2743-2750.2002 | pmc=133736 }}<br />
*{{cite journal | author=Rayman JB, Takahashi Y, Indjeian VB, ''et al.'' |title=E2F mediates cell cycle-dependent transcriptional repression in vivo by recruitment of an HDAC1/mSin3B corepressor complex | url=https://archive.org/details/sim_genes-development_2002-04-15_16_8/page/932 |journal=Genes Dev. |volume=16 |issue= 8 |pages= 933–47 |year= 2002 |pmid= 11959842 |doi= 10.1101/gad.969202 | pmc=152357 }}<br />
*{{cite journal | author=Koipally J, Georgopoulos K |title=A molecular dissection of the repression circuitry of Ikaros | url=https://archive.org/details/sim_journal-of-biological-chemistry_2002-08-02_277_31/page/27696 |journal=J. Biol. Chem. |volume=277 |issue= 31 |pages= 27697–705 |year= 2002 |pmid= 12015313 |doi= 10.1074/jbc.M201694200 }}<br />
*{{cite journal | author=Yang L, Mei Q, Zielinska-Kwiatkowska A, ''et al.'' |title=An ERG (ets-related gene)-associated histone methyltransferase interacts with histone deacetylases 1/2 and transcription co-repressors mSin3A/B |journal=Biochem. J. |volume=369 |issue= Pt 3 |pages= 651–7 |year= 2003 |pmid= 12398767 |doi= 10.1042/BJ20020854 | pmc=1223118 }}<br />
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}<br />
*{{cite journal | author=Petrie K, Guidez F, Howell L, ''et al.'' |title=The histone deacetylase 9 gene encodes multiple protein isoforms | url=https://archive.org/details/sim_journal-of-biological-chemistry_2003-05-02_278_18/page/16058 |journal=J. Biol. Chem. |volume=278 |issue= 18 |pages= 16059–72 |year= 2003 |pmid= 12590135 |doi= 10.1074/jbc.M212935200 }}<br />
*{{cite journal | author=Wysocka J, Myers MP, Laherty CD, ''et al.'' |title=Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell-proliferation factor HCF-1 | url=https://archive.org/details/sim_genes-development_2003-04-01_17_7/page/896 |journal=Genes Dev. |volume=17 |issue= 7 |pages= 896–911 |year= 2003 |pmid= 12670868 |doi= 10.1101/gad.252103 | pmc=196026 }}<br />
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}<br />
*{{cite journal | author=Dugast-Darzacq C, Pirity M, Blanck JK, ''et al.'' |title=Mxi1-SRalpha: a novel Mxi1 isoform with enhanced transcriptional repression potential |journal=Oncogene |volume=23 |issue= 55 |pages= 8887–99 |year= 2004 |pmid= 15467743 |doi= 10.1038/sj.onc.1208107 }}<br />
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}<br />
*{{cite journal | author=Rampalli S, Pavithra L, Bhatt A, ''et al.'' |title=Tumor Suppressor SMAR1 Mediates Cyclin D1 Repression by Recruitment of the SIN3/Histone Deacetylase 1 Complex | url=https://archive.org/details/sim_molecular-and-cellular-biology_2005-10_25_19/page/8415 |journal=Mol. Cell. Biol. |volume=25 |issue= 19 |pages= 8415–29 |year= 2005 |pmid= 16166625 |doi= 10.1128/MCB.25.19.8415-8429.2005 | pmc=1265755 }}<br />
*{{cite journal | author=Xu Y, Sengupta PK, Seto E, Smith BD |title=RFX family proteins differentially interact with HDACs to repress collagen alpha 2(I) gene (COL1A2) expression | url=https://archive.org/details/sim_journal-of-biological-chemistry_2006-04-07_281_14/page/9260 |journal=J. Biol. Chem. |volume=281 |issue= 14 |pages= 9260–70 |year= 2006 |pmid= 16464847 |doi= 10.1074/jbc.M511724200 | pmc=1434794 }}<br />
}}<br />
{{refend}}<br />
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==外部链接==<br />
* {{MeshName|SIN3B+protein,+human}}<br />
{{NLM content}}<br />
{{PDB Gallery|geneid=23309}}<br />
{{Transcription coregulators}}<br />
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[[Category:基因表現]]</div>
imported>曦城星月