2026年2月9日 (一) 04:47 imported>曦城星月

2026-02-09T04:47:36Z

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{{PBB|geneid=25942}}
'''成对两亲性螺旋蛋白SIN3A'''（{{langx|en|Paired amphipathic helix protein Sin3a}}）化学式为：C6419H10097O1950N1817S39<ref>{{Cite web |title=Expasy - ProtParam |url=https://web.expasy.org/cgi-bin/protparam/protparam_bis.cgi?Q96ST3@1-1273@ |website=web.expasy.org |access-date=2026-02-09}}</ref>，是一个由人类[[基因]]''SIN3A''编码的[[蛋白质]]<ref name="pmid10773092">{{cite journal | author = Yu F, Thiesen J, Stratling WH | title = Histone deacetylase-independent transcriptional repression by methyl-CpG-binding protein 2 | journal = Nucleic Acids Res | volume = 28 | issue = 10 | pages = 2201–6 | pmid = 10773092 | pmc = 105362 | doi =10.1093/nar/28.10.2201 |date=June 2000}}</ref><ref name="pmid7601471">{{cite journal | author = Halleck MS, Pownall S, Harder KW, Duncan AM, Jirik FR, Schlegel RA | title = A widely distributed putative mammalian transcriptional regulator containing multiple paired amphipathic helices, with similarity to yeast SIN3 | journal = Genomics | volume = 26 | issue = 2 | pages = 403–6 | pmid = 7601471 | pmc = | doi =10.1016/0888-7543(95)80229-F |date=August 1995}}</ref>。

== 功能 ==
SIN3A是一种[[转录]]调控蛋白，包含有成对[[两亲分子|两亲性]]螺旋结构域（paired amphipathic helix，PAH），对蛋白质互作非常重要<ref>{{cite web | title = Entrez Gene: SIN3A SIN3 homolog A, transcription regulator (yeast)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=25942| accessdate = }}</ref>。

==互作==
SIN3A与下列蛋白有[[蛋白質交互作用|相互作用]]：
{{div col|colwidth=20em}}
* [[CABIN1]]<ref name = pmid10933397>{{cite journal | author = Youn HD, Liu JO | title = Cabin1 represses MEF2-dependent Nur77 expression and T cell apoptosis by controlling association of histone deacetylases and acetylases with MEF2 | journal = Immunity | volume = 13 | issue = 1 | pages = 85–94 | year = 2000 | pmid = 10933397 | doi = 10.1016/S1074-7613(00)00010-8}}</ref>
* [[HBP1]],<ref name = pmid15235594/>
* [[HDAC1]],<ref name = pmid12943729>{{cite journal | author = Zhang Y, Dufau ML | title = Dual mechanisms of regulation of transcription of luteinizing hormone receptor gene by nuclear orphan receptors and histone deacetylase complexes | journal = J. Steroid Biochem. Mol. Biol. | volume = 85 | issue = 2-5 | pages = 401–14 | year = 2003 | pmid = 12943729 | doi = 10.1016/S0960-0760(03)00230-9}}</ref><ref name = pmid12920132>{{cite journal | author = Yao YL, Yang WM | title = The metastasis-associated proteins 1 and 2 form distinct protein complexes with histone deacetylase activity | url = https://archive.org/details/sim_journal-of-biological-chemistry_2003-10-24_278_43/page/42560 | journal = J. Biol. Chem. | volume = 278 | issue = 43 | pages = 42560–8 | year = 2003 | pmid = 12920132 | doi = 10.1074/jbc.M302955200}}</ref><ref name = pmid12724404/><ref name = pmid12398767>{{cite journal | author = Yang L, Mei Q, Zielinska-Kwiatkowska A, Matsui Y, Blackburn ML, Benedetti D, Krumm AA, Taborsky GJ, Chansky HA | title = An ERG (ets-related gene)-associated histone methyltransferase interacts with histone deacetylases 1/2 and transcription co-repressors mSin3A/B | journal = Biochem. J. | volume = 369 | issue = Pt 3 | pages = 651–7 | year = 2003 | pmid = 12398767 | pmc = 1223118 | doi = 10.1042/BJ20020854}}</ref><ref name = pmid10220385>{{cite journal | author = Grozinger CM, Hassig CA, Schreiber SL | title = Three proteins define a class of human histone deacetylases related to yeast Hda1p | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 96 | issue = 9 | pages = 4868–73 | year = 1999 | pmid = 10220385 | pmc = 21783 | doi = 10.1073/pnas.96.9.4868}}</ref><ref name = pmid11931768>{{cite journal | author = Zhang J, Kalkum M, Chait BT, Roeder RG | title = The N-CoR-HDAC3 nuclear receptor corepressor complex inhibits the JNK pathway through the integral subunit GPS2 | journal = Mol. Cell | volume = 9 | issue = 3 | pages = 611–23 | year = 2002 | pmid = 11931768 | doi = 10.1016/S1097-2765(02)00468-9}}</ref><ref name = pmid11171972>{{cite journal | author = You A, Tong JK, Grozinger CM, Schreiber SL | title = CoREST is an integral component of the CoREST- human histone deacetylase complex | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 98 | issue = 4 | pages = 1454–8 | year = 2001 | pmid = 11171972 | pmc = 29278 | doi = 10.1073/pnas.98.4.1454}}</ref><ref name = pmid10444591>{{cite journal | author = Zhang Y, Ng HH, Erdjument-Bromage H, Tempst P, Bird A, Reinberg D | title = Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation | url = https://archive.org/details/sim_genes-development_1999-08-01_13_15/page/1924 | journal = Genes Dev. | volume = 13 | issue = 15 | pages = 1924–35 | year = 1999 | pmid = 10444591 | pmc = 316920 | doi = 10.1101/gad.13.15.1924}}</ref><ref name = pmid12091390>{{cite journal | author = Zhang Y, Dufau ML | title = Silencing of transcription of the human luteinizing hormone receptor gene by histone deacetylase-mSin3A complex | url = https://archive.org/details/sim_journal-of-biological-chemistry_2002-09-06_277_36/page/33431 | journal = J. Biol. Chem. | volume = 277 | issue = 36 | pages = 33431–8 | year = 2002 | pmid = 12091390 | doi = 10.1074/jbc.M204417200}}</ref><ref name = pmid9804427>{{cite journal | author = Tong JK, Hassig CA, Schnitzler GR, Kingston RE, Schreiber SL | title = Chromatin deacetylation by an ATP-dependent nucleosome remodelling complex | url = https://archive.org/details/sim_nature-uk_1998-10-29_395_6705/page/916 | journal = Nature | volume = 395 | issue = 6705 | pages = 917–21 | year = 1998 | pmid = 9804427 | doi = 10.1038/27699}}</ref><ref name = pmid9520398>{{cite journal | author = Hassig CA, Tong JK, Fleischer TC, Owa T, Grable PG, Ayer DE, Schreiber SL | title = A role for histone deacetylase activity in HDAC1-mediated transcriptional repression | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 95 | issue = 7 | pages = 3519–24 | year = 1998 | pmid = 9520398 | pmc = 19868 | doi = 10.1073/pnas.95.7.3519}}</ref><ref name = pmid12374985>{{cite journal | author = Yasui D, Miyano M, Cai S, Varga-Weisz P, Kohwi-Shigematsu T | title = SATB1 targets chromatin remodelling to regulate genes over long distances | url = https://archive.org/details/sim_nature-uk_2002-10-10_419_6907/page/640 | journal = Nature | volume = 419 | issue = 6907 | pages = 641–5 | year = 2002 | pmid = 12374985 | doi = 10.1038/nature01084}}</ref><ref name = pmid10640275/><ref name = pmid11784859/>
* [[HDAC9]],<ref name = pmid11959865>{{cite journal | author = Koipally J, Georgopoulos K | title = Ikaros-CtIP interactions do not require C-terminal binding protein and participate in a deacetylase-independent mode of repression | url = https://archive.org/details/sim_journal-of-biological-chemistry_2002-06-28_277_26/page/23142 | journal = J. Biol. Chem. | volume = 277 | issue = 26 | pages = 23143–9 | year = 2002 | pmid = 11959865 | doi = 10.1074/jbc.M202079200}}</ref><ref name = pmid12590135>{{cite journal | author = Petrie K, Guidez F, Howell L, Healy L, Waxman S, Greaves M, Zelent A | title = The histone deacetylase 9 gene encodes multiple protein isoforms | url = https://archive.org/details/sim_journal-of-biological-chemistry_2003-05-02_278_18/page/16058 | journal = J. Biol. Chem. | volume = 278 | issue = 18 | pages = 16059–72 | year = 2003 | pmid = 12590135 | doi = 10.1074/jbc.M212935200}}</ref>
* [[Histone deacetylase 2]],<ref name = pmid12943729/><ref name = pmid12724404/><ref name = pmid12398767/><ref name = pmid12091390/><ref name = pmid9804427/><ref name = pmid12493763>{{cite journal | author = Hakimi MA, Dong Y, Lane WS, Speicher DW, Shiekhattar R | title = A candidate X-linked mental retardation gene is a component of a new family of histone deacetylase-containing complexes | url = https://archive.org/details/sim_journal-of-biological-chemistry_2003-02-28_278_9/page/7234 | journal = J. Biol. Chem. | volume = 278 | issue = 9 | pages = 7234–9 | year = 2003 | pmid = 12493763 | doi = 10.1074/jbc.M208992200}}</ref><ref name = pmid9150134>{{cite journal | author = Laherty CD, Yang WM, Sun JM, Davie JR, Seto E, Eisenman RN | title = Histone deacetylases associated with the mSin3 corepressor mediate mad transcriptional repression | journal = Cell | volume = 89 | issue = 3 | pages = 349–56 | year = 1997 | pmid = 9150134 | doi = 10.1016/S0092-8674(00)80215-9}}</ref>
* [[Host cell factor C1]],<ref name = pmid15199122>{{cite journal | author = Yokoyama A, Wang Z, Wysocka J, Sanyal M, Aufiero DJ, Kitabayashi I, Herr W, Cleary ML | title = Leukemia proto-oncoprotein MLL forms a SET1-like histone methyltransferase complex with menin to regulate Hox gene expression | url = https://archive.org/details/sim_molecular-and-cellular-biology_2004-07_24_13/page/5639 | journal = Mol. Cell. Biol. | volume = 24 | issue = 13 | pages = 5639–49 | year = 2004 | pmid = 15199122 | pmc = 480881 | doi = 10.1128/MCB.24.13.5639-5649.2004}}</ref><ref name = pmid12670868>{{cite journal | author = Wysocka J, Myers MP, Laherty CD, Eisenman RN, Herr W | title = Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell-proliferation factor HCF-1 | url = https://archive.org/details/sim_genes-development_2003-04-01_17_7/page/896 | journal = Genes Dev. | volume = 17 | issue = 7 | pages = 896–911 | year = 2003 | pmid = 12670868 | pmc = 196026 | doi = 10.1101/gad.252103}}</ref>
* [[IKZF1]],<ref name = pmid11959865/><ref name = pmid10357820>{{cite journal | author = Koipally J, Renold A, Kim J, Georgopoulos K | title = Repression by Ikaros and Aiolos is mediated through histone deacetylase complexes | url = https://archive.org/details/sim_embo-journal_1999-06-01_18_11/page/3090 | journal = EMBO J. | volume = 18 | issue = 11 | pages = 3090–100 | year = 1999 | pmid = 10357820 | pmc = 1171390 | doi = 10.1093/emboj/18.11.3090}}</ref><ref name = pmid12015313>{{cite journal | author = Koipally J, Georgopoulos K | title = A molecular dissection of the repression circuitry of Ikaros | url = https://archive.org/details/sim_journal-of-biological-chemistry_2002-08-02_277_31/page/27696 | journal = J. Biol. Chem. | volume = 277 | issue = 31 | pages = 27697–705 | year = 2002 | pmid = 12015313 | doi = 10.1074/jbc.M201694200}}</ref>
* [[ING1]],<ref name = pmid11784859/>
* [[KLF11]],<ref name = pmid11438660>{{cite journal | author = Zhang JS, Moncrieffe MC, Kaczynski J, Ellenrieder V, Prendergast FG, Urrutia R | title = A conserved alpha-helical motif mediates the interaction of Sp1-like transcriptional repressors with the corepressor mSin3A | url = https://archive.org/details/sim_molecular-and-cellular-biology_2001-08_21_15/page/5041 | journal = Mol. Cell. Biol. | volume = 21 | issue = 15 | pages = 5041–9 | year = 2001 | pmid = 11438660 | pmc = 87230 | doi = 10.1128/MCB.21.15.5041-5049.2001}}</ref><ref name = pmid12006497>{{cite journal | author = Ellenrieder V, Zhang JS, Kaczynski J, Urrutia R | title = Signaling disrupts mSin3A binding to the Mad1-like Sin3-interacting domain of TIEG2, an Sp1-like repressor | url = https://archive.org/details/sim_embo-journal_2002-05-15_21_10/page/2450 | journal = EMBO J. | volume = 21 | issue = 10 | pages = 2451–60 | year = 2002 | pmid = 12006497 | pmc = 126002 | doi = 10.1093/emboj/21.10.2451}}</ref>
* [[MNT (gene)|MNT]],<ref name = pmid9184233>{{cite journal | author = Meroni G, Reymond A, Alcalay M, Borsani G, Tanigami A, Tonlorenzi R, Lo Nigro C, Messali S, Zollo M, Ledbetter DH, Brent R, Ballabio A, Carrozzo R | title = Rox, a novel bHLHZip protein expressed in quiescent cells that heterodimerizes with Max, binds a non-canonical E box and acts as a transcriptional repressor | url = https://archive.org/details/sim_embo-journal_1997-05-15_16_10/page/2892 | journal = EMBO J. | volume = 16 | issue = 10 | pages = 2892–906 | year = 1997 | pmid = 9184233 | pmc = 1169897 | doi = 10.1093/emboj/16.10.2892}}</ref>
* [[MXD1]],<ref name = pmid15235594>{{cite journal | author = Swanson KA, Knoepfler PS, Huang K, Kang RS, Cowley SM, Laherty CD, Eisenman RN, Radhakrishnan I | title = HBP1 and Mad1 repressors bind the Sin3 corepressor PAH2 domain with opposite helical orientations | journal = Nat. Struct. Mol. Biol. | volume = 11 | issue = 8 | pages = 738–46 | year = 2004 | pmid = 15235594 | doi = 10.1038/nsmb798}}</ref><ref name = pmid11106735>{{cite journal | author = Brubaker K, Cowley SM, Huang K, Loo L, Yochum GS, Ayer DE, Eisenman RN, Radhakrishnan I | title = Solution structure of the interacting domains of the Mad-Sin3 complex: implications for recruitment of a chromatin-modifying complex | journal = Cell | volume = 103 | issue = 4 | pages = 655–65 | year = 2000 | pmid = 11106735 | doi = 10.1016/S0092-8674(00)00168-9}}</ref><ref name = pmid7889570>{{cite journal | author = Ayer DE, Lawrence QA, Eisenman RN | title = Mad-Max transcriptional repression is mediated by ternary complex formation with mammalian homologs of yeast repressor Sin3 | journal = Cell | volume = 80 | issue = 5 | pages = 767–76 | year = 1995 | pmid = 7889570 | doi = 10.1016/0092-8674(95)90355-0}}</ref>
* [[Methyl-CpG-binding domain protein 2]],<ref name = pmid10950960>{{cite journal | author = Boeke J, Ammerpohl O, Kegel S, Moehren U, Renkawitz R | title = The minimal repression domain of MBD2b overlaps with the methyl-CpG-binding domain and binds directly to Sin3A | url = https://archive.org/details/sim_journal-of-biological-chemistry_2000-11-10_275_45/page/34962 | journal = J. Biol. Chem. | volume = 275 | issue = 45 | pages = 34963–7 | year = 2000 | pmid = 10950960 | doi = 10.1074/jbc.M005929200}}</ref>
* [[Nuclear receptor co-repressor 2]],<ref name = pmid10640275>{{cite journal | author = Huang EY, Zhang J, Miska EA, Guenther MG, Kouzarides T, Lazar MA | title = Nuclear receptor corepressors partner with class II histone deacetylases in a Sin3-independent repression pathway | url = https://archive.org/details/sim_genes-development_2000-01-01_14_1/page/44 | journal = Genes Dev. | volume = 14 | issue = 1 | pages = 45–54 | year = 2000 | pmid = 10640275 | pmc = 316335 | doi = }}</ref><ref name = pmid10944117>{{cite journal | author = Li J, Wang J, Wang J, Nawaz Z, Liu JM, Qin J, Wong J | title = Both corepressor proteins SMRT and N-CoR exist in large protein complexes containing HDAC3 | url = https://archive.org/details/sim_embo-journal_2000-08-15_19_16/page/4342 | journal = EMBO J. | volume = 19 | issue = 16 | pages = 4342–50 | year = 2000 | pmid = 10944117 | pmc = 302030 | doi = 10.1093/emboj/19.16.4342}}</ref>
* [[OGT (gene)|OGT]]<ref name = pmid12150998>{{cite journal | author = Yang X, Zhang F, Kudlow JE | title = Recruitment of O-GlcNAc transferase to promoters by corepressor mSin3A: coupling protein O-GlcNAcylation to transcriptional repression | journal = Cell | volume = 110 | issue = 1 | pages = 69–80 | year = 2002 | pmid = 12150998 | doi = 10.1016/S0092-8674(02)00810-3}}</ref>
* [[PHF12]],<ref name = pmid11390640/>
* [[早幼粒细胞白血病蛋白]]<ref name = pmid11430826>{{cite journal | author = Khan MM, Nomura T, Kim H, Kaul SC, Wadhwa R, Shinagawa T, Ichikawa-Iwata E, Zhong S, Pandolfi PP, Ishii S | title = Role of PML and PML-RARalpha in Mad-mediated transcriptional repression | journal = Mol. Cell | volume = 7 | issue = 6 | pages = 1233–43 | year = 2001 | pmid = 11430826 | doi = 10.1016/S1097-2765(01)00257-X}}</ref>
* [[RBBP4]],<ref name = pmid9150133>{{cite journal | author = Hassig CA, Fleischer TC, Billin AN, Schreiber SL, Ayer DE | title = Histone deacetylase activity is required for full transcriptional repression by mSin3A | journal = Cell | volume = 89 | issue = 3 | pages = 341–7 | year = 1997 | pmid = 9150133 | doi = 10.1016/S0092-8674(00)80214-7}}</ref><ref name = pmid9651585/>
* [[RBBP7]],<ref name = pmid11784859>{{cite journal | author = Kuzmichev A, Zhang Y, Erdjument-Bromage H, Tempst P, Reinberg D | title = Role of the Sin3-histone deacetylase complex in growth regulation by the candidate tumor suppressor p33(ING1) | url = https://archive.org/details/sim_molecular-and-cellular-biology_2002-02_22_3/page/835 | journal = Mol. Cell. Biol. | volume = 22 | issue = 3 | pages = 835–48 | year = 2002 | pmid = 11784859 | pmc = 133546 | doi = 10.1128/MCB.22.3.835-848.2002}}</ref><ref name = pmid9651585>{{cite journal | author = Zhang Y, Sun ZW, Iratni R, Erdjument-Bromage H, Tempst P, Hampsey M, Reinberg D | title = SAP30, a novel protein conserved between human and yeast, is a component of a histone deacetylase complex | journal = Mol. Cell | volume = 1 | issue = 7 | pages = 1021–31 | year = 1998 | pmid = 9651585 | doi = 10.1016/S1097-2765(00)80102-1}}</ref>
* [[SAP130]],<ref name = pmid12724404>{{cite journal | author = Fleischer TC, Yun UJ, Ayer DE | title = Identification and characterization of three new components of the mSin3A corepressor complex | url = https://archive.org/details/sim_molecular-and-cellular-biology_2003-05_23_10/page/3456 | journal = Mol. Cell. Biol. | volume = 23 | issue = 10 | pages = 3456–67 | year = 2003 | pmid = 12724404 | pmc = 164750 | doi = 10.1128/MCB.23.10.3456-3467.2003}}</ref>
* [[SAP30]],<ref name = pmid12724404/><ref name = pmid10444591/><ref name = pmid11784859/><ref name = pmid11390640>{{cite journal | author = Yochum GS, Ayer DE | title = Pf1, a novel PHD zinc finger protein that links the TLE corepressor to the mSin3A-histone deacetylase complex | url = https://archive.org/details/sim_molecular-and-cellular-biology_2001-07_21_13/page/4110 | journal = Mol. Cell. Biol. | volume = 21 | issue = 13 | pages = 4110–8 | year = 2001 | pmid = 11390640 | pmc = 87072 | doi = 10.1128/MCB.21.13.4110-4118.2001}}</ref><ref name = pmid9651585/><ref name = pmid9702189>{{cite journal | author = Laherty CD, Billin AN, Lavinsky RM, Yochum GS, Bush AC, Sun JM, Mullen TM, Davie JR, Rose DW, Glass CK, Rosenfeld MG, Ayer DE, Eisenman RN | title = SAP30, a component of the mSin3 corepressor complex involved in N-CoR-mediated repression by specific transcription factors | journal = Mol. Cell | volume = 2 | issue = 1 | pages = 33–42 | year = 1998 | pmid = 9702189 | doi = 10.1016/S1097-2765(00)80111-2}}</ref>
* [[SMARCA2]],<ref name = pmid11238380>{{cite journal | author = Sif S, Saurin AJ, Imbalzano AN, Kingston RE | title = Purification and characterization of mSin3A-containing Brg1 and hBrm chromatin remodeling complexes | url = https://archive.org/details/sim_genes-development_2001-03-01_15_5/page/602 | journal = Genes Dev. | volume = 15 | issue = 5 | pages = 603–18 | year = 2001 | pmid = 11238380 | pmc = 312641 | doi = 10.1101/gad.872801}}</ref>
* [[SMARCA4]],<ref name = pmid11784859/><ref name = pmid11238380/>
* [[SMARCC1]],<ref name = pmid11784859/><ref name = pmid11238380/>
* [[SUDS3]],<ref name = pmid12724404/><ref name = pmid11909966>{{cite journal | author = Alland L, David G, Shen-Li H, Potes J, Muhle R, Lee HC, Hou H, Chen K, DePinho RA | title = Identification of mammalian Sds3 as an integral component of the Sin3/histone deacetylase corepressor complex | url = https://archive.org/details/sim_molecular-and-cellular-biology_2002-04_22_8/page/2743 | journal = Mol. Cell. Biol. | volume = 22 | issue = 8 | pages = 2743–50 | year = 2002 | pmid = 11909966 | pmc = 133736 | doi = 10.1128/MCB.22.8.2743-2750.2002}}</ref>
* [[TAL1]],<ref name = pmid10688671>{{cite journal | author = Huang S, Brandt SJ | title = mSin3A regulates murine erythroleukemia cell differentiation through association with the TAL1 (or SCL) transcription factor | url = https://archive.org/details/sim_molecular-and-cellular-biology_2000-03_20_6/page/2248 | journal = Mol. Cell. Biol. | volume = 20 | issue = 6 | pages = 2248–59 | year = 2000 | pmid = 10688671 | pmc = 110841 | doi = 10.1128/MCB.20.6.2248-2259.2000}}</ref>and
* [[Zinc finger and BTB domain-containing protein 16]].<ref name = pmid9627120>{{cite journal | author = David G, Alland L, Hong SH, Wong CW, DePinho RA, Dejean A | title = Histone deacetylase associated with mSin3A mediates repression by the acute promyelocytic leukemia-associated PLZF protein | journal = Oncogene | volume = 16 | issue = 19 | pages = 2549–56 | year = 1998 | pmid = 9627120 | doi = 10.1038/sj.onc.1202043}}</ref><ref name = pmid11719366>{{cite journal | author = Ward JO, McConnell MJ, Carlile GW, Pandolfi PP, Licht JD, Freedman LP | title = The acute promyelocytic leukemia-associated protein, promyelocytic leukemia zinc finger, regulates 1,25-dihydroxyvitamin D(3)-induced monocytic differentiation of U937 cells through a physical interaction with vitamin D(3) receptor | url = https://archive.org/details/sim_blood_2001-12-01_98_12/page/3290 | journal = Blood | volume = 98 | issue = 12 | pages = 3290–300 | year = 2001 | pmid = 11719366 | doi = 10.1182/blood.V98.12.3290}}</ref><ref name = pmid9765306>{{cite journal | author = Wong CW, Privalsky ML | title = Components of the SMRT corepressor complex exhibit distinctive interactions with the POZ domain oncoproteins PLZF, PLZF-RARalpha, and BCL-6 | url = https://archive.org/details/sim_journal-of-biological-chemistry_1998-10-16_273_42/page/27694 | journal = J. Biol. Chem. | volume = 273 | issue = 42 | pages = 27695–702 | year = 1998 | pmid = 9765306 | doi = 10.1074/jbc.273.42.27695}}</ref>
{{Div col end}}

==另见==
* [[Transcription coregulator]]

==参考文献==
{{Reflist|3}}

==延伸阅读==
{{Refbegin|3}}
*{{cite journal | author=Zhang Y, Dufau ML |title=Dual mechanisms of regulation of transcription of luteinizing hormone receptor gene by nuclear orphan receptors and histone deacetylase complexes. |journal=J. Steroid Biochem. Mol. Biol. |volume=85 |issue= 2-5 |pages= 401–14 |year= 2003 |pmid= 12943729 |doi=10.1016/S0960-0760(03)00230-9 }}
*{{cite journal | author=Ayer DE, Lawrence QA, Eisenman RN |title=Mad-Max transcriptional repression is mediated by ternary complex formation with mammalian homologs of yeast repressor Sin3. |journal=Cell |volume=80 |issue= 5 |pages= 767–76 |year= 1995 |pmid= 7889570 |doi=10.1016/0092-8674(95)90355-0 }}
*{{cite journal | author=Hurlin PJ, Quéva C, Koskinen PJ, ''et al.'' |title=Mad3 and Mad4: novel Max-interacting transcriptional repressors that suppress c-myc dependent transformation and are expressed during neural and epidermal differentiation. |journal=EMBO J. |volume=14 |issue= 22 |pages= 5646–59 |year= 1996 |pmid= 8521822 |doi= | pmc=394680 }}
*{{cite journal | author=Hassig CA, Fleischer TC, Billin AN, ''et al.'' |title=Histone deacetylase activity is required for full transcriptional repression by mSin3A. |journal=Cell |volume=89 |issue= 3 |pages= 341–7 |year= 1997 |pmid= 9150133 |doi=10.1016/S0092-8674(00)80214-7 }}
*{{cite journal | author=Laherty CD, Yang WM, Sun JM, ''et al.'' |title=Histone deacetylases associated with the mSin3 corepressor mediate mad transcriptional repression. |journal=Cell |volume=89 |issue= 3 |pages= 349–56 |year= 1997 |pmid= 9150134 |doi=10.1016/S0092-8674(00)80215-9 }}
*{{cite journal | author=Zhang Y, Iratni R, Erdjument-Bromage H, ''et al.'' |title=Histone deacetylases and SAP18, a novel polypeptide, are components of a human Sin3 complex. |journal=Cell |volume=89 |issue= 3 |pages= 357–64 |year= 1997 |pmid= 9150135 |doi=10.1016/S0092-8674(00)80216-0 }}
*{{cite journal | author=Meroni G, Reymond A, Alcalay M, ''et al.'' |title=Rox, a novel bHLHZip protein expressed in quiescent cells that heterodimerizes with Max, binds a non-canonical E box and acts as a transcriptional repressor. | url=https://archive.org/details/sim_embo-journal_1997-05-15_16_10/page/2892 |journal=EMBO J. |volume=16 |issue= 10 |pages= 2892–906 |year= 1997 |pmid= 9184233 |doi= 10.1093/emboj/16.10.2892 | pmc=1169897 }}
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{{Refend}}

==外部链接==
* {{MeshName|SIN3A+protein,+human}}
* {{FactorBook|Sin3Ak-20}}

{{PDB Gallery|geneid=25942}}
{{Transcription coregulators}}
{{NLM content}}

[[Category:基因表現]]

SIN3A - 版本历史

2026年2月9日 (一) 04:47 imported>曦城星月