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SIB-1893 - 版本历史
2026-07-18T19:20:26Z
本wiki上该页面的版本历史
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imported>147258et：內容擴充 增加或調整內部連結
2025-11-01T14:03:57Z
<p>內容擴充 增加或調整內部連結</p>
<p><b>新页面</b></p><div>{{Drugbox<br />
| Verifiedfields = changed<br />
| Watchedfields = changed<br />
| verifiedrevid = 402053704<br />
| IUPAC_name = (E)-2-methyl-6-(2-phenylethenyl)pyridine<br />
| image = SIB-1893_structure.png<br />
| width = 200<br />
| ChEMBL_Ref = {{ebicite|changed|EBI}}<br />
| ChEMBL = 88612<br />
<br />
<!--Clinical data--><br />
| tradename = <br />
| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X --><br />
| pregnancy_US = <!-- A / B / C / D / X --><br />
| pregnancy_category = <br />
| legal_AU = <!-- Unscheduled / S2 / S3 / S4 / S5 / S6 / S7 / S8 / S9 --><br />
| legal_CA = <!-- / Schedule I, II, III, IV, V, VI, VII, VIII --><br />
| legal_UK = <!-- GSL / P / POM / CD / Class A, B, C --><br />
| legal_US = <!-- OTC / Rx-only / Schedule I, II, III, IV, V --><br />
| legal_status = <br />
| routes_of_administration =<br />
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<!--Pharmacokinetic data--><br />
| bioavailability = <br />
| protein_bound = <br />
| metabolism = <br />
| elimination_half-life = <br />
| excretion =<br />
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<!--Identifiers--><br />
| CAS_number_Ref = {{cascite|correct|CAS}}<br />
| CAS_number = 7370-21-0<br />
| CAS_number_Comment = ''trans''<br />
| CAS_number2 = 6266-99-5<br />
| CAS_number2_Ref = {{cascite|correct|CAS}}<br />
| ATC_prefix = <br />
| ATC_suffix = <br />
| PubChem = 235382<br />
| DrugBank_Ref = {{drugbankcite|correct|drugbank}}<br />
| DrugBank =<br />
| ChemSpiderID_Ref = {{chemspidercite|changed|chemspider}}<br />
| ChemSpiderID = 4470920<br />
| UNII_Ref = {{fdacite|correct|FDA}}<br />
| UNII = 4X2F5X24UK<br />
<br />
<!--Chemical data--><br />
| C=14 | H=13 | N=1<br />
| smiles = c1ccccc1\C=C\c(nc2C)ccc2<br />
| StdInChI_Ref = {{stdinchicite|changed|chemspider}}<br />
| StdInChI = 1S/C14H13N/c1-12-6-5-9-14(15-12)11-10-13-7-3-2-4-8-13/h2-11H,1H3/b11-10+<br />
| StdInChIKey_Ref = {{stdinchicite|changed|chemspider}}<br />
| StdInChIKey = SISOFUCTXZKSOQ-ZHACJKMWSA-N<br />
}}<br />
'''SIB-1893'''是一种[[有机化合物]]，化学式为C<sub>14</sub>H<sub>13</sub>N。它可由2-甲基-6-苯乙炔基吡啶和[[硫化钠]]九水合物在[[二甲基甲酰胺]]中于140 °C反应制得。<ref>{{cite journal|journal=Organic Letters|volume=16|issue=11|language=en|issn=1523-7060|date=2014-06-06|pages=3020–3023|doi=10.1021/ol501137x|url=https://pubs.acs.org/doi/10.1021/ol501137x|title=Transition-Metal-Free Semihydrogenation of Diarylalkynes: Highly Stereoselective Synthesis of trans -Alkenes Using Na 2 S·9H 2 O|accessdate=2021-09-21|author=Zhengwang Chen, Miaoting Luo, Yuelu Wen, Guotian Luo, Liangxian Liu|archive-date=2021-09-21|archive-url=https://web.archive.org/web/20210921060414/https://pubs.acs.org/doi/10.1021/ol501137x}}</ref>以[[苯甲醛]]和[[2,6-二甲基吡啶]]为原料在路易斯酸催化下反应，也可得到该化合物。<ref>{{cite journal|journal=European Journal of Organic Chemistry|volume=2014|issue=14|language=en|date=2014-05|pages=3009–3019|doi=10.1002/ejoc.201400073|url=https://onlinelibrary.wiley.com/doi/10.1002/ejoc.201400073|title=Lewis-Acid-Catalyzed Benzylic Reactions of 2-Methylazaarenes with Aldehydes: Benzylic Reactions of 2-Methylazaarenes|accessdate=2021-09-21|author=Dan Mao, Gang Hong, Shengying Wu, Xin Liu, Jianjun Yu, Limin Wang}}</ref>在[[草酸]]二水合物的存在下，它可以发生光[[二聚作用|二聚反应]]（又稱二聚作用），得到1,3-二苯基-2,4-二(6-甲基吡啶-2-基)环丁烷<!-- CAS 2414635-38-2 -->。<ref>{{cite journal|journal=Chemistry – A European Journal|volume=26|issue=21|language=en|issn=0947-6539|date=2020-04-09|pages=4682–4689|doi=10.1002/chem.201905597|url=https://onlinelibrary.wiley.com/doi/10.1002/chem.201905597|title=[2+2] Photodimerization of Stilbazoles Promoted by Oxalic Acid in Suspension|accessdate=2021-09-21|author=Thanh Binh Nguyen, Tuan Minh Nguyen, Pascal Retailleau}}</ref><br />
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==参考文献==<br />
{{reflist}}<br />
<br />
[[Category:吡啶]]<br />
[[Category:受体拮抗剂]]<br />
[[Category:乙烯基苯]]</div>
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