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SB-200646 - 版本历史
2026-07-20T02:15:14Z
本wiki上该页面的版本历史
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<p><b>新页面</b></p><div>{{drugbox<br />
| drug_name = <br />
| IUPAC_name = 1-(1-Methyl-1''H''-indol-5-yl)-3-pyridin-3-ylurea<br />
| image = SB-200646.svg<br />
| alt = <br />
| caption =<br />
<!-- Clinical data --><br />
| pronounce =<br />
| tradename = <br />
| Drugs.com = <br />
| MedlinePlus = <br />
| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X --><br />
| pregnancy_AU_comment = <br />
| pregnancy_US = <!-- A / B / C / D / X / N --><br />
| pregnancy_category= <br />
| legal_AU = <br />
| legal_AU_comment =<br />
| legal_CA = <br />
| legal_DE = <br />
| legal_NZ = <br />
| legal_UK = <br />
| legal_US = <br />
| legal_UN = Unscheduled<br />
| legal_status = <br />
| routes_of_administration =<br />
<br />
<!-- Pharmacokinetic data --><br />
| bioavailability = <br />
| protein_bound = <br />
| metabolism = <br />
| metabolites =<br />
| onset = <br />
| elimination_half-life = <br />
| duration_of_action =<br />
| excretion =<br />
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<!-- Identifiers --><br />
| CAS_number = 143797-63-1<br />
| CAS_number_Ref= {{cascite|correct|CAS}}<br />
| ATCvet = <br />
| ATC_prefix = none<br />
| ATC_suffix = <br />
| PubChem = 126769<br />
| DrugBank =<br />
| ChEMBL = 85194<br />
| ChEBI = 8976<br />
| ChemSpiderID = 112592<br />
| KEGG = C11739<br />
<br />
<!-- Chemical data --><br />
| C=15 | H=14 | N=4 | O=1<br />
| StdInChI = 1S/C15H14N4O/c1-19-8-6-11-9-12(4-5-14(11)19)17-15(20)18-13-3-2-7-16-10-13/h2-10H,1H3,(H2,17,18,20)<br />
| StdInChIKey = OJZZJTLBYXHUSJ-UHFFFAOYSA-N<br />
| smiles = Cn1ccc2c1ccc(c2)NC(=O)Nc3cccnc3<br />
}}<br />
'''{{PAGENAME}}'''是一种[[氮化合物|含氮]][[有机化合物]]，化学式[[C15H14N4O|C<sub>15</sub>H<sub>14</sub>N<sub>4</sub>O]]，能作为[[5-HT2受體|5-HT<sub>2</sub>受體]]的[[受体拮抗剂]]，在大鼠中有[[抗焦慮藥]]作用<ref>{{cite journal | vauthors = Kennett GA, Wood MD, Glen A, Grewal S, Forbes I, Gadre A, Blackburn TP | title = In vivo properties of SB 200646A, a 5-HT2C/2B receptor antagonist | url = https://archive.org/details/sim_british-journal-of-pharmacology_1994-03_111_3/page/n162 | journal = British Journal of Pharmacology | volume = 111 | issue = 3 | pages = 797–802 | date = March 1994 | pmid = 7912626 | pmc = 1910094 | doi = 10.1111/j.1476-5381.1994.tb14808.x }}</ref>。<br />
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== 参考资料 ==<br />
{{Reflist}}<br />
<br />
== 外部链接 ==<br />
<br />
[[Category:5-HT2B拮抗剂]]<br />
[[Category:5-HT2C拮抗剂]]<br />
[[Category:抗焦虑药]]<br />
[[Category:吲哚]]<br />
[[Category:3-吡啶基化合物]]<br />
[[Category:脲]]</div>
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