2024年4月2日 (二) 03:54 imported>CYCcc

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{{medical}}
{{Drugbox
| Verifiedfields = changed
| Watchedfields = changed
| verifiedrevid = 451559889
| IUPAC_name = (''S'')-2,3-dihydro-[3,4]cyclopentano-1,2,4-benzothiadiazine-1,1-dioxide
| image = S-18986.svg
| width = 200px


| tradename =
| pregnancy_AU = 
| pregnancy_US = 
| pregnancy_category =
| legal_AU = 
| legal_CA =
| legal_UK =
| legal_US = Investigational New Drug
| legal_status =
| routes_of_administration =


| bioavailability =
| protein_bound =
| metabolism =
| excretion =


| IUPHAR_ligand = 4304
| CAS_number_Ref = {{cascite|correct|CAS}}
| CAS_number = 175340-20-2
| UNII_Ref = {{fdacite|correct|FDA}}
| UNII = IA262432Y9
| ATC_prefix =
| ATC_suffix =
| PubChem = 637863
| DrugBank_Ref = {{drugbankcite|correct|drugbank}}
| ChemSpiderID_Ref = {{chemspidercite|changed|chemspider}}
| ChemSpiderID = 553445


| C=10 | H=12 | N=2 | O=2 | S=1
| smiles = C1C[C@@H]2NS(=O)(=O)C3=CC=CC=C3N2C1
| StdInChI_Ref = {{stdinchicite|changed|chemspider}}
| StdInChI = 1S/C10H12N2O2S/c13-15(14)9-5-2-1-4-8(9)12-7-3-6-10(12)11-15/h1-2,4-5,10-11H,3,6-7H2/t10-/m1/s1
| StdInChIKey_Ref = {{stdinchicite|changed|chemspider}}
| StdInChIKey = MNTIJYGEITVWHU-SNVBAGLBSA-N
}}
'''S-18986'''，是一种与环噻嗪相关的[[AMPA受体]][[正变构调节剂]]。动物研究發現S-18986有[[益智藥|促智]]和[[神经保护]]的作用，另外這種物質能誘導大脑[[海马体|海馬體]]及[[額葉|额叶皮层]]中[[脑源性神经营养因子]]和'''[[AMPA|α-氨基-3-羥基-5-甲基-4-異惡唑丙酸]]'''（AMPA）介导[[去甲肾上腺素]]及[[乙酰胆碱]]释放。<ref name="pmid10924919">{{Cite journal|title=(S)-2,3-dihydro-[3,4]cyclopentano-1,2,4-benzothiadiazine-1,1-dioxide: (S18986-1) a positive modulator of AMPA receptors enhances (S)-AMPA-mediated [3H]noradrenaline release from rat hippocampal and frontal cortex slices|date=August 2000|journal=European Journal of Pharmacology|issue=2|doi=10.1016/S0014-2999(00)00433-7|volume=401|pages=145–53|pmid=10924919}}</ref><ref name="pmid10924928">{{Cite journal|title=Effects of S 18986-1, a novel cognitive enhancer, on memory performances in an object recognition task in rats|date=August 2000|journal=European Journal of Pharmacology|issue=2|doi=10.1016/S0014-2999(00)00429-5|volume=401|pages=205–12|pmid=10924928}}</ref><ref name="pmid12706264">{{Cite journal|title=Positive allosteric modulators of AMPA receptors are neuroprotective against lesions induced by an NMDA agonist in neonatal mouse brain|date=April 2003|journal=Brain Research|issue=1–2|doi=10.1016/S0006-8993(03)02357-6|volume=970|pages=221–5|pmid=12706264}}</ref><ref name="pmid15135908">{{Cite journal|title=S 18986, a positive modulator of AMPA receptors with cognition-enhancing properties, increases ACh release in the hippocampus of young and aged rat|date=May 2004|journal=Neuroscience Letters|issue=1–3|doi=10.1016/j.neulet.2003.12.061|volume=361|pages=120–3|pmid=15135908}}</ref><ref name="pmid15860654">{{Cite journal|title=Neuropharmacokinetics of a new alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) modulator, S18986 [(S)-2,3-dihydro-[3,4]cyclopentano-1,2,4-benzothiadiazine-1,1-dioxide], in the rat|date=August 2005|journal=Drug Metabolism and Disposition|issue=8|doi=10.1124/dmd.105.004424|volume=33|pages=1137–43|pmid=15860654}}</ref><ref name="pmid17384936">{{Cite journal|title=Improvement of episodic contextual memory by S 18986 in middle-aged mice: comparison with donepezil|url=https://archive.org/details/sim_psychopharmacology_2007-07_193_1/page/63|date=July 2007|journal=Psychopharmacology|issue=1|doi=10.1007/s00213-007-0765-4|volume=193|pages=63–73|pmid=17384936}}</ref><ref name="pmid18469541">{{Cite journal|title=The AMPA modulator S 18986 improves declarative and working memory performances in aged mice|date=May 2008|journal=Behavioural Pharmacology|issue=3|doi=10.1097/FBP.0b013e3282feb0c1|volume=19|pages=235–44|pmid=18469541}}</ref><ref name="pmid18762915">{{Cite journal|title=Effects of the AMPA receptor modulator S 18986 on measures of cognition and oxidative stress in aged rats|date=January 2009|journal=Psychopharmacology|issue=1–3|doi=10.1007/s00213-008-1301-x|volume=202|pages=225–35|pmid=18762915}}</ref><ref name="pmid19136940">{{Cite journal|title=GAP-43 is essential for the neurotrophic effects of BDNF and positive AMPA receptor modulator S18986|date=April 2009|journal=Cell Death and Differentiation|issue=4|doi=10.1038/cdd.2008.188|volume=16|pages=624–37|pmid=19136940}}</ref><ref name="pmid19501111">{{Cite journal|title=The AMPA receptor positive allosteric modulator, S18986, is neuroprotective against neonatal excitotoxic and inflammatory brain damage through BDNF synthesis|date=September 2009|journal=Neuropharmacology|issue=3|doi=10.1016/j.neuropharm.2009.05.010|volume=57|pages=277–86|pmid=19501111}}</ref>

== 參見 ==

* [[AMPA受體正變構調節劑]]

== 参考文獻 ==
{{Reflist}}
[[Category:试验药物]]

S-18986 - 版本历史

2024年4月2日 (二) 03:54 imported>CYCcc