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Ro 5-3663 - 版本历史
2026-07-19T22:40:21Z
本wiki上该页面的版本历史
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imported>Nucleus hydro elemon：/* Ro 5-3663 */ // Edit via Wikiplus
2024-01-16T13:04:30Z
<p><span class="autocomment">Ro 5-3663：</span> // Edit via Wikiplus</p>
<p><b>新页面</b></p><div>{{Chembox<br />
| Name = <br />
| NameEn = <br />
| ImageFile = RO-5-3663.svg<br />
| ImageSize = <br />
| ImageAlt = <br />
| IUPACName = <br />
| IUPACNameZh = <br />
| OtherNames = 5-甲基-1''H''-苯并[''e''][1,4]二氮杂环庚三烯-2(3''H'')-酮<br />
| Section1 = {{Chembox Identifiers<br />
| CASNo = 70656-87-0<br />
| CASNo_Ref = {{cascite|correct|CAS}}<br />
| PubChem = 135432558<br />
| SMILES = O=C1NC=2C=CC=CC2C(=NC1)C }}<br />
| Section2 = {{Chembox Properties<br />
| C=10 | H=10 | N=2 | O=1<br />
| Appearance = 白色固体<ref name=Jung /><br />
| Density = <br />
| MeltingPt = 178~181 °C<ref name=Jung /><br />
| BoilingPt = <br />
| Solubility = }}<br />
| Section3 = {{Chembox Hazards<br />
| MainHazards = <br />
| FlashPt = <br />
| Autoignition = }}<br />
}}<br />
'''Ro 5-3663'''是一种有机化合物，化学式为[[C10H10N2O|C<sub>10</sub>H<sub>10</sub>N<sub>2</sub>O]]，其化学名为1,3-二氢-5-甲基-2''H''-1,4-苯二氮䓬-2-酮。它可以[[2'-氨基苯乙酮]]和[[N-叔丁氧羰基甘氨酸]]（或N-芴甲氧羰基甘氨酸<ref name=Jung>Kwan-Young Jung; Steven Fletcher. Fine-tuning the chemo- and regioselective alkylation of 1,4-benzodiazepines: further applications of the Mitsunobu reaction. ''MedChemComm'', 2012. {{doi|10.1039/C2MD20123B}}.</ref>）为原料反应制得。<ref>Romain Siegrist, Davide Pozzi, Gaël Jacob, Caterina Torrisi, Kilian Colas, Bertrand Braibant, Jacques Mawet, Thomas Pfeifer, Ruben de Kanter, Catherine Roch, Melanie Kessler, Richard Moon, Olivier Corminboeuf, Olivier Bezençon. Structure-Activity Relationship, Drug Metabolism and Pharmacokinetics Properties Optimization, and in Vivo Studies of New Brain Penetrant Triple T-Type Calcium Channel Blockers. Journal of Medicinal Chemistry (2016), 59 (23), 10661-10675. {{doi|10.1021/acs.jmedchem.6b01356}}.</ref>它和[[苯甲醇]]（或[[异丙醇]]）、[[三丁基膦]]、[[偶氮二甲酸二异丙酯|DIAD]]在[[三氯甲烷]]中反应，可以得到1-苄基-Ro 5-3663或1-异丙基-Ro 5-3663。<ref name=Jung /><br />
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==参考文献==<br />
{{reflist}}<br />
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[[Category:甲基化合物]]</div>
imported>Nucleus hydro elemon