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Ro67-4853 - 版本历史
2026-07-20T06:30:14Z
本wiki上该页面的版本历史
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imported>Htmlzycq：使用HotCat已移除Category:丁酯; 已添加Category:正丁酯
2023-11-19T09:19:20Z
<p>使用<a href="/index.php?title=WP:HOTCAT&action=edit&redlink=1" class="new" title="WP:HOTCAT（页面不存在）">HotCat</a>已移除<a href="/index.php?title=Category:%E4%B8%81%E9%85%AF&action=edit&redlink=1" class="new" title="Category:丁酯（页面不存在）">Category:丁酯</a>; 已添加<a href="/wiki/Category:%E6%AD%A3%E4%B8%81%E9%85%AF" title="Category:正丁酯">Category:正丁酯</a></p>
<p><b>新页面</b></p><div>{{Drugbox<br />
| Watchedfields = changed<br />
| verifiedrevid = 425136175<br />
| IUPAC_name = butyl (9H-xanthene-9-carbonyl)carbamate<br />
| image = [[File:Ro67-4853_structure.png|frameless|Ro67-4853 2D skeltal]]<br />
| width = 250px<br />
| image2 = [[File:Ro67-4853.png|frameless|Ro67-4853 3D BS]]<br />
| width2 = 250px<br />
<br />
<!--Clinical data--><br />
| tradename = <br />
| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X --><br />
| pregnancy_US = <!-- A / B / C / D / X --><br />
| legal_AU = <!-- Unscheduled / S2 / S3 / S4 / S5 / S6 / S7 / S8 / S9 --><br />
| legal_CA = <!-- / Schedule I, II, III, IV, V, VI, VII, VIII --><br />
| legal_UK = <!-- GSL / P / POM / CD / Class A, B, C --><br />
| legal_US = <!-- OTC / Rx-only / Schedule I, II, III, IV, V --><br />
<br />
<!--Identifiers--><br />
| CAS_number = 302841-89-0<br />
| PubChem = 9949202<br />
| IUPHAR_ligand = 1387<br />
| ChemSpiderID = 8124813<br />
<br />
<!--Chemical data--><br />
| C=19 | H=19 | N=1 | O=4 <br />
| smiles = c3cccc2c3Oc1ccccc1C2C(=O)NC(=O)OCCCC<br />
| StdInChI = 1S/C19H19NO4/c1-2-3-12-23-19(22)20-18(21)17-13-8-4-6-10-15(13)24-16-11-7-5-9-14(16)17/h4-11,17H,2-3,12H2,1H3,(H,20,21,22)<br />
| StdInChIKey = RQBUXEUMZZQUFY-UHFFFAOYSA-N<br />
}}<br />
'''{{PAGENAME}}'''是一种含氮[[有机化合物]]，化学式为[[C19H19NO4|C<sub>19</sub>H<sub>19</sub>NO<sub>4</sub>]]，作为[[代谢型谷氨酸受体]]的[[GRM1|mGluR<sub>1</sub>]]亚型的[[别构调节剂]]用于科学研究。<ref name="pmid11606768">{{cite journal |vauthors=Knoflach F, Mutel V, Jolidon S, Kew JN, Malherbe P, Vieira E, Wichmann J, Kemp JA |title=Positive allosteric modulators of metabotropic glutamate 1 receptor: characterization, mechanism of action, and binding site |journal=Proceedings of the National Academy of Sciences of the United States of America |volume=98 |issue=23 |pages=13402–7 |date=November 2001 |pmid=11606768 |pmc=60883 |doi=10.1073/pnas.231358298 |bibcode=2001PNAS...9813402K |doi-access=free }}</ref><ref name="pmid16645124">{{cite journal |vauthors=Hemstapat K, de Paulis T, Chen Y, Brady AE, Grover VK, Alagille D, Tamagnan GD, Conn PJ |title=A novel class of positive allosteric modulators of metabotropic glutamate receptor subtype 1 interact with a site distinct from that of negative allosteric modulators |journal=Molecular Pharmacology |volume=70 |issue=2 |pages=616–626 |date=August 2006 |pmid=16645124 |doi=10.1124/mol.105.021857 |s2cid=2719603 |url=http://pdfs.semanticscholar.org/3c5d/1685fa51ec475d1ee0b1500af13d3150a182.pdf |archive-url=https://web.archive.org/web/20190222090830/http://pdfs.semanticscholar.org/3c5d/1685fa51ec475d1ee0b1500af13d3150a182.pdf |url-status=dead |archive-date=2019-02-22 }}</ref><ref name="pmid18625258">{{cite journal |vauthors=Sheffler DJ, Conn PJ |title=Allosteric potentiators of metabotropic glutamate receptor subtype 1a differentially modulate independent signaling pathways in baby hamster kidney cells |journal=Neuropharmacology |volume=55 |issue=4 |pages=419–27 |date=September 2008 |pmid=18625258 |doi=10.1016/j.neuropharm.2008.06.047 |pmc=2600811}}</ref><br />
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==参考文献==<br />
{{reflist}}<br />
<br />
==外部链接==<br />
<br />
[[Category:正丁酯]]<br />
[[Category:呫吨]]<br />
[[Category:氨基甲酸酯]]</div>
imported>Htmlzycq