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RAD51 - 版本历史
2026-07-16T19:22:43Z
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2020-09-26T17:07:08Z
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<p><b>新页面</b></p><div>{{Infobox_gene}}<br />
{{protein<br />
|Name=RAD51<br />
|caption=Rad51結構圖。來源：{{PDB|1SZP}}<ref>[http://www.rcsb.org/pdb/explore/explore.do?structureId=1SZP] {{Wayback|url=http://www.rcsb.org/pdb/explore/explore.do?structureId=1SZP |date=20110517083722 }} Conway, A.B., Lynch, T.W., Zhang, Y., Fortin, G.S., Fung, C.W., Symington, L.S., Rice, P.A. Crystal structure of a Rad51 filament. ''Nat.Struct.Mol.Biol.'' '''v11''' pp.791-796, 2004</ref><br />
|image=1SZP.jpg<br />
|width=<br />
|HGNCid=9817<br />
|Symbol=RAD51<br />
|AltSymbols=RAD51A, RECA<br />
|EntrezGene=5888<br />
|OMIM=179617<br />
|RefSeq=NM_002875<br />
|UniProt=Q06609<br />
|PDB=1SZP<br />
|ECnumber=<br />
|Chromosome=15號<br />
|Arm=q<br />
|Band=15.1<br />
|LocusSupplementaryData=<br />
}}<br />
<br />
'''Rad51'''是[[真核生物]]體內的一種[[蛋白質]]，与原核生物的[[RecA]][[同源]]，是一种高度保守的蛋白，從[[酵母菌]]到[[人類]]之間的變異不大。人類的Rad51含有339個[[氨基酸]]，於[[同源重組]]中扮演主要角色，參與搜尋同源部位與DNA的配對過程。<br />
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人類的Rad51的基因位於[[15號染色體 (人類)|第15號染色體]]。包括此基因在內，[[哺乳類]]共有七種類似recA的基因，包括Rad51、Rad51L1/B、Rad51L2/C、Rad51L3/D、XRCC2、XRCC3以及DMC1<ref>Kawabata,M., Kawabata, T. and Nishibori, M. Role of recA/Rad51 family proteins in mammals. ''Acta Med.Okayama'' '''v59''', No.1, pp.1-9(2005)</ref>。<br />
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== 參考文獻 ==<br />
{{reflist|2}} <br />
* Galkin,V .E. ''et al''. The Rad51/RadA N-Terminal domain activates nucleoprotein filament ATPase activity. Structure 14, pp. 983-992(2006)<br />
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* Pellegrini, L. ''et al''. Insights into DNA recombination from the structure of a Rad51-BRCA2 complex. Nature 420,287-293(2002)<br />
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== 外部連結 ==<br />
* {{MeshName|RAD51+Protein}}<br />
{{DNA修复}}<br />
[[Category:蛋白質]]</div>
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