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{{Infobox biodatabase
|title = 蛋白质家族数据库<br>Pfam
|logo = [[File:Pfam logo.gif|120px]]
|description = Pfam数据库为蛋白质结构域提供比对和[[隐马尔可夫模型]]
|scope = [[蛋白质家族]]
|organism = 全部
|center = [[欧洲生物信息研究所]]
|laboratory =
|author =
|pmid = 19920124
|released =
|standard =
|format = {{le|斯德哥尔摩格式|Stockholm format}}
|url = {{URL|www.ebi.ac.uk/interpro/entry/pfam/#table}}
|download = [https://ftp.ebi.ac.uk/pub/databases/Pfam 文件传输协议]
|webservice =
|sql =
|sparql =
|webapp =
|standalone =
|license = [[GNU宽通用公共许可证]]
|versioning =
|frequency =
|curation =
|bookmark = 是
|version = 37.0
}}
'''蛋白质家族数据库'''（{{langx|en|Pfam}}，其为'''p'''rotein '''fam'''ily〔蛋白质家族〕的[[混成词]]），是一個[[蛋白質家族]]資料庫。此資料庫會利用[[隱馬爾可夫模型]]進行[[多重序列比對]]以及加上蛋白腳註<ref name="pmid18039703">{{cite journal |author=Finn RD, Tate J, Mistry J, Coggill PC, Sammut SJ, Hotz HR, Ceric G, Forslund K, Eddy SR, Sonnhammer EL, Bateman A |title=The Pfam protein families database |journal=Nucleic Acids Res |volume=36 |issue=Database issue |pages=D281–8 |year=2008 |pmid=18039703 |doi=10.1093/nar/gkm960 |pmc=2238907}}</ref><ref name="pmid16381856">{{cite journal|title=Pfam: clans, web tools and services|pages=D247–251|issn=1362-4962|journal=Nucleic Acids Research|volume=34|issue=Database issue|date=2006-01-01|doi=10.1093/nar/gkj149|url=https://www.ncbi.nlm.nih.gov/pubmed/16381856|accessdate=2019-02-12|author=Robert D. Finn, Jaina Mistry, Benjamin Schuster-Böckler, Sam Griffiths-Jones, Volker Hollich, Timo Lassmann, Simon Moxon, Mhairi Marshall, Ajay Khanna, Richard Durbin, Sean R. Eddy, Erik L. L. Sonnhammer, Alex Bateman|pmid=16381856|pmc=1347511|archive-date=2019-10-16|archive-url=https://web.archive.org/web/20191016182044/https://www.ncbi.nlm.nih.gov/pubmed/16381856|dead-url=no}}</ref><ref name="pmid14681378">{{cite journal|title=The Pfam protein families database|pages=D138–141|issn=1362-4962|journal=Nucleic Acids Research|volume=32|issue=Database issue|date=2004-01-01|doi=10.1093/nar/gkh121|url=https://www.ncbi.nlm.nih.gov/pubmed/14681378|accessdate=2019-02-12|author=Alex Bateman, Lachlan Coin, Richard Durbin, Robert D. Finn, Volker Hollich, Sam Griffiths-Jones, Ajay Khanna, Mhairi Marshall, Simon Moxon, Erik L. L. Sonnhammer, David J. Studholme, Corin Yeats, Sean R. Eddy|pmid=14681378|pmc=308855|archive-date=2019-03-28|archive-url=https://web.archive.org/web/20190328152232/https://www.ncbi.nlm.nih.gov/pubmed/14681378|dead-url=no}}</ref>。

== 特色 ==
Pfam中所登錄的每一個蛋白質家族可以：

* 查詢多重序列比對
* 查看蛋白質主要結構
* 檢視物種演化樹
* 連結其他資料庫
* 查看已知的蛋白質結構

Pfam內的蛋白質家族描述由維基百科使用者管理。

Pfam的最新版本是「Pfam 34.0」（2021年3月，共計19,179個家族）<ref>{{cite web |url=ftp://ftp.sanger.ac.uk/pub/databases/Pfam/current_release/relnotes.txt |title=Pfam release notes |publisher=Sanger |accessdate=2012-01-12 }}{{dead link|date=2017年11月 |bot=InternetArchiveBot |fix-attempted=yes }}</ref>

==參見==
*[[TrEMBL]] Database performing an automated protein sequence annotation
*{{le|InterPro}} Integration of protein domain and protein family databases
*[http://dunbrack2.fccc.edu/protcid/pdbfam PDBfam]{{Wayback|url=http://dunbrack2.fccc.edu/protcid/pdbfam |date=20151001120514 }} — thorough assignment of Pfam domains to sequences in the [[Protein Data Bank]] (PDB)<ref>{{cite web|last=Dunbrack|first=Roland|title=PDBfam|url=http://dunbrack2.fccc.edu/protcid/pdbfam/|work=PDBfam|publisher=Fox Chase Cancer Center|accessdate=9 March 2013|archive-date=2015-10-01|archive-url=https://web.archive.org/web/20151001120514/http://dunbrack2.fccc.edu/protcid/pdbfam/|dead-url=yes}}</ref><ref>{{cite journal|last=Xu|first=Qifang|author2=Dunbrack, Roland|title=Assignment of protein sequences to existing domain and family classification systems: Pfam and the PDB|journal=Bioinformatics|year=2012|volume=28|doi=10.1093/bioinformatics/bts533|pmid=22942020|issue=21|pages=2763–72|pmc=3476341}}</ref>

==參考文獻==
{{reflist|2}}

==外部連結==
*[https://web.archive.org/web/20140420020108/http://pfam.sanger.ac.uk/ Pfam] －[[英國]][[Sanger Institute]]的蛋白質家族資料庫
*[https://pfam.janelia.org/ Pfam]{{Wayback|url=https://pfam.janelia.org/ |date=20160304225518 }} －[[美國]][[珍利亞農場研究園區]]的蛋白質家族資料庫
*[http://pfam.sbc.su.se/ Pfam]{{Wayback|url=http://pfam.sbc.su.se/ |date=20140109022137 }} －[[瑞典]]{{le|Stockholm Bioinformatics Centre}}的蛋白質家族資料庫
*[https://web.archive.org/web/20110107193546/http://www.sanger.ac.uk/Software/Pfam/iPfam/ iPfam] - Interactions of Pfam domains in PDB
*[http://dunbrack2.fccc.edu/protcid/pdbfam/ PDBfam]{{Wayback|url=http://dunbrack2.fccc.edu/protcid/pdbfam/ |date=20151001120514 }} - Assignments of Pfam domains to sequences in the PDB at {{le|Fox Chase Cancer Center}} USA

[[Category:生物信息學]]
[[Category:蛋白质数据库]]

Pfam - 版本历史

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