imported>Htmlzycq：增加或调整内部链接

2025-10-29T14:15:42Z

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{{Drugbox
| Verifiedfields = changed
| verifiedrevid = 451562202
| IUPAC_name = 2-morpholin-4-ylethyl 1-phenylcyclohexane-1-carboxylate
| image = PRE-084_SVG_file.svg
| width = 200


| tradename =
| pregnancy_AU =
| pregnancy_US =
| pregnancy_category =
| legal_AU =
| legal_CA =
| legal_UK =
| legal_US =
| legal_status =
| routes_of_administration =


| bioavailability =
| protein_bound =
| metabolism =
| elimination_half-life =
| excretion =


| IUPHAR_ligand = 6678
| CAS_number_Ref = {{cascite|correct|??}}
| CAS_number = 138847-85-5
| UNII_Ref = {{fdacite|correct|FDA}}
| UNII = 74BW8WG2MQ
| ATC_prefix = none
| ATC_suffix =
| PubChem = 126402
| ChemSpiderID_Ref = {{chemspidercite|changed|chemspider}}
| ChemSpiderID = 112335


| C=19 | H=27 | N=1 | O=3
| smiles = c1ccccc1C2(CCCCC2)C(=O)OCCN3CCOCC3
| StdInChI_Ref = {{stdinchicite|changed|chemspider}}
| StdInChI = 1S/C19H27NO3/c21-18(23-16-13-20-11-14-22-15-12-20)19(9-5-2-6-10-19)17-7-3-1-4-8-17/h1,3-4,7-8H,2,5-6,9-16H2
| StdInChIKey_Ref = {{stdinchicite|changed|chemspider}}
| StdInChIKey = RQHKZUBCUZVZEF-UHFFFAOYSA-N
| melting_point =
| melting_high =
}}
'''{{PAGENAME}}'''是一种含氮[[有机化合物]]，化学式[[C19H27NO3|{{chem2|C19H27NO3}}]]，能作为[[σ受体]]特别是σ<sub>1</sub>的选择性[[激动剂]]，在动物实验中有[[益智藥]]、[[抗抑郁药]]和[[止咳藥]]作用<ref name="pmid7886099">{{cite journal |vauthors=Maurice T, Su TP, Parish DW, Nabeshima T, Privat A |title=PRE-084, a sigma selective PCP derivative, attenuates MK-801-induced impairment of learning in mice |journal=Pharmacology Biochemistry and Behavior |volume=49 |issue=4 |pages=859–69 |date=December 1994 |pmid=7886099 |doi= 10.1016/0091-3057(94)90235-6|s2cid=54306053 |url=https://zenodo.org/record/1258299}}</ref><ref name="pmid11728429">{{cite journal |author=Maurice T |title=Beneficial effect of the sigma(1) receptor agonist PRE-084 against the spatial learning deficits in aged rats |journal=European Journal of Pharmacology |volume=431 |issue=2 |pages=223–7 |date=November 2001 |pmid=11728429 |doi= 10.1016/S0014-2999(01)01436-4}}</ref><ref name="pmid14691051">{{cite journal |vauthors=Brown C, Fezoui M, Selig WM, Schwartz CE, Ellis JL |title=Antitussive activity of sigma-1 receptor agonists in the guinea-pig |url=https://archive.org/details/sim_british-journal-of-pharmacology_2004-01_141_2/page/232 |journal=[[British Journal of Pharmacology]] |volume=141 |issue=2 |pages=233–40 |date=January 2004 |pmid=14691051 |pmc=1574192 |doi=10.1038/sj.bjp.0705605 }}</ref><ref name="pmid20081254">{{cite journal |vauthors=Skuza G, Rogóz Z |title=Antidepressant-like effect of PRE-084, a selective sigma1 receptor agonist, in Albino Swiss and C57BL/6J mice |journal=Pharmacological Reports |volume=61 |issue=6 |pages=1179–83 |year=2009 |pmid=20081254 |doi= 10.1016/S1734-1140(09)70181-1|s2cid=96025873 }}</ref><ref name="pmid19892920">{{cite journal |vauthors=Hiranita T, Soto PL, Tanda G, Katz JL |title=Reinforcing effects of sigma-receptor agonists in rats trained to self-administer cocaine |url=https://archive.org/details/sim_journal-of-pharmacology-and-experimental-therapeutics_2010-02_332_2/page/n186 |journal=The Journal of Pharmacology and Experimental Therapeutics |volume=332 |issue=2 |pages=515–24 |date=February 2010 |pmid=19892920 |doi=10.1124/jpet.109.159236 |pmc=2812106}}</ref>。

== 参考文献 ==
{{reflist}}

[[Category:Σ激动剂]]
[[Category:羧酸酯]]
[[Category:4-吗啉基化合物]]
[[Category:解离性药物]]

PRE-084 - 版本历史

imported>Htmlzycq：​增加或调整内部链接

imported>Htmlzycq：增加或调整内部链接