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PHCCC - 版本历史
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| Watchedfields = changed<br />
| verifiedrevid = 425013184<br />
| IUPAC_name = (−)-N-Phenyl-7-(hydroxyimino)cyclopropa[b]chromen-1a-carboxamide<br />
| image = PHCCC_structure.png<br />
| width = 200<br />
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<!--Clinical data--><br />
| tradename = <br />
| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X --><br />
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| legal_AU = <!-- Unscheduled / S2 / S3 / S4 / S5 / S6 / S7 / S8 / S9 --><br />
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<!--Identifiers--><br />
| CAS_number = 179068-02-1<br />
| PubChem = 3579925<br />
| ChemSpiderID = 2816644<br />
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<!--Chemical data--><br />
| C=17 | H=14 | N=2 | O=3<br />
| StdInChI=1S/C17H14N2O3/c20-16(18-11-6-2-1-3-7-11)17-10-13(17)15(19-21)12-8-4-5-9-14(12)22-17/h1-9,13,21H,10H2,(H,18,20)<br />
| StdInChIKey = FPXPIEZPAXSELW-UHFFFAOYSA-N <br />
| smiles = c4ccccc4NC(=O)C1(CC1C2=NO)Oc3ccccc23<br />
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'''PHCCC'''是一种作为{{le|谷氨酸受体|glutamate receptor}}配体的研究药物，可以作为{{le|代谢型谷氨酸受体4|Metabotropic glutamate receptor 4|mGluR<sub>4</sub>}}的正向变构调节剂<ref name="pmid14573382">{{cite journal |vauthors=Maj M, Bruno V, Dragic Z, Yamamoto R, Battaglia G, Inderbitzin W, Stoehr N, Stein T, Gasparini F, Vranesic I, Kuhn R, Nicoletti F, Flor PJ |title=(−)-PHCCC, a positive allosteric modulator of mGluR4: characterization, mechanism of action, and neuroprotection |url=https://archive.org/details/sim_neuropharmacology_2003-12_45_7/page/894 |journal=Neuropharmacology |volume=45 |issue=7 |pages=895–906 |date=December 2003 |pmid=14573382 |doi= 10.1016/S0028-3908(03)00271-5|s2cid=17446511 }}</ref>和mGluR<sub>6</sub>的激动剂。<ref name="pmid18593581">{{cite journal |vauthors=Beqollari D, Kammermeier PJ |title=The mGlu(4) receptor allosteric modulator N-phenyl-7-(hydroxyimino)cyclopropa[b]chromen-1a-carboxamide acts as a direct agonist at mGlu(6) receptors |journal=European Journal of Pharmacology |volume=589 |issue=1–3 |pages=49–52 |date=July 2008 |pmid=18593581 |doi=10.1016/j.ejphar.2008.06.054 }}</ref>动物研究表明，它具有抗焦虑作用。<ref name="pmid15363989">{{cite journal |vauthors=Stachowicz K, Kłak K, Kłodzińska A, Chojnacka-Wojcik E, Pilc A |title=Anxiolytic-like effects of PHCCC, an allosteric modulator of mGlu4 receptors, in rats |journal=European Journal of Pharmacology |volume=498 |issue=1–3 |pages=153–6 |date=September 2004 |pmid=15363989 |doi=10.1016/j.ejphar.2004.07.001 }}</ref>它和类似药物被提议用于治疗[[帕金森病]]。<ref name="pmid18664603">{{cite journal |vauthors=Niswender CM, Johnson KA, Weaver CD, Jones CK, Xiang Z, Luo Q, Rodriguez AL, Marlo JE, de Paulis T, Thompson AD, Days EL, Nalywajko T, Austin CA, Williams MB, Ayala JE, Williams R, Lindsley CW, Conn PJ |title=Discovery, characterization, and antiparkinsonian effect of novel positive allosteric modulators of metabotropic glutamate receptor 4 |journal=Molecular Pharmacology |volume=74 |issue=5 |pages=1345–58 |date=November 2008 |pmid=18664603 |doi=10.1124/mol.108.049551 |pmc=2574552}}</ref><br />
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==参考文献==<br />
{{Reflist|2}}<br />
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