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{{Chembox|Name=PD-137889
|ImageFile=PD-137889 Structure.svg|ImageSize=|ImageAlt=|IUPACName=(4aR)-''N''-Methyl-1,2,3,4,9,9a-hexahydro-4a''H''-fluoren-4a-amine|OtherNames=|Section1={{Chembox Identifiers
| CASNo = 95372-93-3
| CASNo_Ref = {{cascite|correct|CAS}}
| CASNo2 = 147128-60-7
| CASNo2_Ref = {{cascite|correct|CAS}}
| CASNo2_Comment = ''rel''-(4a''R'',9a''S'')
| PubChem = 10104280
| ChemSpiderID = 8279807
| UNII_Ref = {{fdacite|correct|FDA}}
| UNII = 2KU62QB3UM
| SMILES = c12c(cccc1)C3(NC)CCCCC3C2
| InChI=1S/C14H19N/c1-15-14-9-5-4-7-12(14)10-11-6-2-3-8-13(11)14/h2-3,6,8,12,15H,4-5,7,9-10H2,1H3
| InChIKey = KQLIVVYSTDBTMZ-UHFFFAOYSA-N
}}|Section2={{Chembox Properties
| Formula =
| C=14 | H=19 | N=1
| MolarMass =
| Appearance =
| Density =
| MeltingPt =
| BoilingPt =
| Solubility =
}}|Section3={{Chembox Hazards
| MainHazards =
| FlashPt =
| AutoignitionPt =
}}
}}

'''PD-137889'''（'''''N-''甲基六氢芴胺'''）是一種化學化合物，[[中樞神經系統|中枢神经系统]]NMDA受体拮抗剂，效力比[[氯胺酮]]強約30倍<ref>{{Cite journal |last=Hays |first=Sheryl J. |last2=Novak |first2=Perry M. |last3=Ortwine |first3=Daniel F. |last4=Bigge |first4=Christopher F. |last5=Colbry |first5=Norman L. |last6=Johnson |first6=Graham |last7=Lescosky |first7=Leonard J. |last8=Malone |first8=Thomas C. |last9=Michael |first9=Andre |year=1993 |title=Synthesis and pharmacological evaluation of hexahydrofluorenamines as noncompetitive antagonists at the N-methyl-D-aspartate receptor |journal=J Med Chem |volume=36 |issue=6 |page=654–70 |doi=10.1021/jm00058a002 |pmid=8459395}}</ref>，動物研究中可替代[[苯環利定|五氯苯酚]]。<ref>{{Cite journal |last=Nicholson |first=Katherine L. |last2=Balster |first2=Robert L. |year=2003 |title=Evaluation of the phencyclidine-like discriminative stimulus effects of novel NMDA channel blockers in rats |url=https://archive.org/details/sim_psychopharmacology_2003-11_170_2/page/215 |journal=Psychopharmacology |volume=170 |issue=2 |page=215–224 |doi=10.1007/s00213-003-1527-6 |pmid=2851738 |s2cid=30803162}}</ref><ref>{{Cite journal |last=Bigge |first=Christopher F. |year=1993 |title=Structural requirements for the development of potent n-methyl-d-aspartic acid (NMDA) receptor antagonists |url=https://archive.org/details/sim_biochemical-pharmacology_1993-04-22_45_8/page/n6 |journal=Biochemical Pharmacology |volume=45 |issue=8 |page=1547–1561 |doi=10.1016/0006-2952(93)90294-7 |pmid=7683469}}</ref><ref>{{Cite journal |last=Bigge |first=Christopher F. |last2=Malone |first2=Thomas C. |year=1993 |title=Overview: Agonists, Antagonists and Modulators of the N-methyl-D-aspartic acid (NMDA) and α-amino-3-hydroxy-5-methyl-4-isoxazolepropanoic acid (AMPA) Subtypes of Glutamate Receptors |journal=Current Opinion on Therapeutic Patents |volume=3 |issue=7 |page=951–989 |doi=10.1517/13543776.3.7.951}}</ref>K''i''[3H]TCP{{Efn|[3H]N-[1-(2-thienyl)cyclohex-yl]piperidine}} = 27 [[體積莫耳濃度|nM]]，氯胺酮K''i'' = 860 nM。 <ref>[http://patft.uspto.gov/netacgi/nph-Parser?d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=4837226.PN.&OS=PN/4837226&RS=PN/4837226 Polycyclic amine derivatives useful as cerebrovascular agents] {{Wayback|url=http://patft.uspto.gov/netacgi/nph-Parser?d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=4837226.PN.&OS=PN/4837226&RS=PN/4837226 |date=20180203235905 }} United States Patent; Coughenour, et al. Family ID: 22686445 Appl. #07/186,834</ref>

== 参考 ==
{{Reflist}}
{{Notelist}}
[[Category:三环化合物]]
[[Category:镇静药]]
[[Category:N-甲基-D-天冬氨酸受体拮抗剂]]
[[Category:全身麻醉药]]
[[Category:解离性药物]]
[[Category:芳基环己胺]]

PD-137889 - 版本历史

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