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2022-09-27T08:59:15Z

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{{Infobox_gene}}
'''p73'''，又稱爲'''TP73'''，是[[P53 p63 p73家族|p53蛋白家族]]的成員之一，以其[[分子量]]爲73[[千道爾頓|kD]]而得名，存在多種轉錄變體。p73的結構和功能均與p53類似，爲[[腫瘤抑制蛋白]]，能調控細胞增殖並促進細胞凋亡。過表達p73的細胞增殖會停止。

==參見==
*[[p53]]
*[[p63]]

==參考文獻==
{{reflist}}
{{ReflistH|2}}
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*{{Cite journal|title=An Anti-Apoptotic Role for the p53 Family Member, p73, During Developmental Neuron Death|url=https://www.science.org/doi/10.1126/science.289.5477.304|last=Pozniak|first=Christine D.|last2=Radinovic|first2=Stevo|date=2000-07-14|journal=Science|issue=5477|doi=10.1126/science.289.5477.304|volume=289|pages=304–306|language=en|pmid=10894779|issn=0036-8075|last3=Yang|first3=Annie|last4=McKeon|first4=Frank|last5=Kaplan|first5=David R.|last6=Miller|first6=Freda D.|access-date=2021-11-10|archive-date=2021-11-10|archive-url=https://web.archive.org/web/20211110143349/https://www.science.org/doi/10.1126/science.289.5477.304}}
*{{Cite journal|title=p73-deficient mice have neurological, pheromonal and inflammatory defects but lack spontaneous tumours|url=http://www.nature.com/articles/35003607|last=Yang|first=Annie|last2=Walker|first2=Nancy|date=2000-03|journal=Nature|pmid=10716451|issue=6773|doi=10.1038/35003607|volume=404|pages=99–103|language=en|issn=0028-0836|last3=Bronson|first3=Roderick|last4=Kaghad|first4=Mourad|last5=Oosterwegel|first5=Mariette|last6=Bonnin|first6=Jacques|last7=Vagner|first7=Christine|last8=Bonnet|first8=Helene|last9=Dikkes|first9=Pieter|access-date=2021-11-10|archive-date=2022-01-28|archive-url=https://web.archive.org/web/20220128213845/https://www.nature.com/articles/35003607}}
{{PBB Further reading
| citations =
*{{Cite journal|title=The emerging p53 gene family|url=https://pubmed.ncbi.nlm.nih.gov/10203277|last=Kaelin|first=W. G.|date=1999-04-07|journal=Journal of the National Cancer Institute|issue=7|doi=10.1093/jnci/91.7.594|volume=91|pages=594–598|issn=0027-8874|pmid=10203277|access-date=2021-11-10|archive-date=2021-11-10|archive-url=https://web.archive.org/web/20211110143354/https://pubmed.ncbi.nlm.nih.gov/10203277/}}
*{{Cite journal|title=p73|url=https://pubmed.ncbi.nlm.nih.gov/11470228|last=Davis|first=P. K.|last2=Dowdy|first2=S. F.|date=2001-10|journal=The International Journal of Biochemistry & Cell Biology|issue=10|doi=10.1016/s1357-2725(01)00073-5|volume=33|pages=935–939|issn=1357-2725|pmid=11470228|access-date=2021-11-10|archive-date=2021-11-10|archive-url=https://web.archive.org/web/20211110143350/https://pubmed.ncbi.nlm.nih.gov/11470228/}}
*{{Cite journal|title=The role of PML in tumor suppression|url=https://pubmed.ncbi.nlm.nih.gov/11832207|last=Salomoni|first=Paolo|last2=Pandolfi|first2=Pier Paolo|date=2002-01-25|journal=Cell|issue=2|doi=10.1016/s0092-8674(02)00626-8|volume=108|pages=165–170|issn=0092-8674|pmid=11832207|access-date=2021-11-10|archive-date=2022-03-02|archive-url=https://web.archive.org/web/20220302174938/https://pubmed.ncbi.nlm.nih.gov/11832207/}}
*{{Cite journal|title=p73, the "assistant" guardian of the genome?|url=https://pubmed.ncbi.nlm.nih.gov/15033688|last=Melino|first=Gerry|date=2003-12|journal=Annals of the New York Academy of Sciences|doi=10.1196/annals.1299.002|volume=1010|pages=9–15|issn=0077-8923|pmid=15033688|access-date=2021-11-10|archive-date=2021-11-10|archive-url=https://web.archive.org/web/20211110143348/https://pubmed.ncbi.nlm.nih.gov/15033688/}}
*{{Cite journal|title=Neuronal survival and p73/p63/p53: a family affair|url=https://pubmed.ncbi.nlm.nih.gov/15359011|last=Jacobs|first=W. Bradley|last2=Walsh|first2=Gregory S.|date=2004-10|journal=The Neuroscientist: A Review Journal Bringing Neurobiology, Neurology and Psychiatry|issue=5|doi=10.1177/1073858404263456|volume=10|pages=443–455|issn=1073-8584|pmid=15359011|last3=Miller|first3=Freda D.|access-date=2021-11-10|archive-date=2022-02-25|archive-url=https://web.archive.org/web/20220225195957/https://pubmed.ncbi.nlm.nih.gov/15359011/}}
*{{Cite journal|title=Mechanism of induction of apoptosis by p73 and its relevance to neuroblastoma biology|url=https://pubmed.ncbi.nlm.nih.gov/15650240|last=Rossi|first=Mario|last2=Sayan|first2=A. Emre|date=2004-12|journal=Annals of the New York Academy of Sciences|doi=10.1196/annals.1322.015|volume=1028|pages=143–149|issn=0077-8923|pmid=15650240|last3=Terrinoni|first3=Alessandro|last4=Melino|first4=Gerry|last5=Knight|first5=Richard A.|access-date=2021-11-10|archive-date=2021-11-10|archive-url=https://web.archive.org/web/20211110143352/https://pubmed.ncbi.nlm.nih.gov/15650240/}}
*{{cite journal |vauthors=Dobbelstein M, Strano S, Roth J, Blandino G |title=p73-induced apoptosis: a question of compartments and cooperation. |journal=Biochem. Biophys. Res. Commun. |volume=331 |issue= 3 |pages= 688–93 |year= 2005 |pmid= 15865923 |doi= 10.1016/j.bbrc.2005.03.155 }}
*{{Cite journal|title=p73 induces apoptosis by different mechanisms|url=https://pubmed.ncbi.nlm.nih.gov/15865927|last=Ramadan|first=Saafa|last2=Terrinoni|first2=Alessandro|date=2005-06-10|journal=Biochemical and Biophysical Research Communications|issue=3|doi=10.1016/j.bbrc.2005.03.156|volume=331|pages=713–717|issn=0006-291X|pmid=15865927|last3=Catani|first3=Maria Valeria|last4=Sayan|first4=A. Emre|last5=Knight|first5=Richard A.|last6=Mueller|first6=Martina|last7=Krammer|first7=Peter H.|last8=Melino|first8=Gerry|last9=Candi|first9=Eleonora|access-date=2021-11-10|archive-date=2021-11-10|archive-url=https://web.archive.org/web/20211110143357/https://pubmed.ncbi.nlm.nih.gov/15865927/}}
*{{Cite journal|title=p19 ras Brings a New Twist to the Regulation of p73 by Mdm2|url=https://www.science.org/doi/10.1126/stke.3372006pe24|last=Harms|first=Kelly Lynn|last2=Chen|first2=Xinbin|date=2006-05-30|journal=Science's STKE|issue=337|doi=10.1126/stke.3372006pe24|volume=2006|language=en|pmid=16738062|issn=1525-8882|access-date=2021-11-10|archive-date=2022-03-11|archive-url=https://web.archive.org/web/20220311200810/https://www.science.org/doi/10.1126/stke.3372006pe24}}
*{{Cite journal|title=p73: a chiaroscuro gene in cancer|url=https://pubmed.ncbi.nlm.nih.gov/17428654|last=Marabese|first=Mirko|last2=Vikhanskaya|first2=Faina|date=2007-06|journal=European Journal of Cancer (Oxford, England: 1990)|issue=9|doi=10.1016/j.ejca.2007.01.042|volume=43|pages=1361–1372|issn=0959-8049|pmid=17428654|last3=Broggini|first3=Massimo|access-date=2021-11-10|archive-date=2021-11-10|archive-url=https://web.archive.org/web/20211110151956/https://pubmed.ncbi.nlm.nih.gov/17428654/}}
}}
*{{Cite journal|title=The Yes-associated protein 1 stabilizes p73 by preventing Itch-mediated ubiquitination of p73|url=http://www.nature.com/articles/4402063|last=Levy|first=D|last2=Adamovich|first2=Y|date=2007-04|journal=Cell Death & Differentiation|issue=4|doi=10.1038/sj.cdd.4402063|volume=14|pages=743–751|language=en|pmid=17110958|issn=1350-9047|last3=Reuven|first3=N|last4=Shaul|first4=Y|access-date=2021-11-10|archive-date=2022-03-08|archive-url=https://web.archive.org/web/20220308233907/https://www.nature.com/articles/4402063}}
{{ReflistF}}
{{PDB Gallery|geneid=7161}}
{{PDB Gallery|geneid=7157}}
{{转录因子与细胞内受体|g4}}
{{抑癌基因与癌基因}}
{{细胞周期蛋白质}}
{{biochem-stub}}
[[Category:细胞程序性死亡]]
[[Category:蛋白质]]
[[Category:转录因子]]
[[Category:肿瘤抑制基因]]
[[Category:细胞凋亡]]
[[Category:小鼠中突变的基因]]
[[Category:衰老相关蛋白质]]

P73 - 版本历史

imported>Raymon090：​/* 参考文献 */ // Edit via WikiMirror W+

imported>Raymon090：/* 参考文献 */ // Edit via WikiMirror W+