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P1-185 - 版本历史
2026-07-19T04:43:55Z
本wiki上该页面的版本历史
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2025-12-04T10:40:56Z
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<p><b>新页面</b></p><div>{{Drugbox<br />
| Verifiedfields = <br />
| Watchedfields = <br />
| verifiedrevid = <br />
| IUPAC_name = [(''E'')-[(8''S'',9''S'',10''R'',13''S'',14''S'',17''S'')-17-acetyl-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[''a'']phenanthren-3-ylidene]amino] (2''S'')-2-amino-3-methylbutanoate<br />
| image = P1-185.svg<br />
| width = 250px<br />
<br />
<!--Clinical data--><br />
| tradename = <br />
| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X --><br />
| pregnancy_US = <!-- A / B / C / D / X --><br />
| pregnancy_category = <br />
| legal_AU = <!-- Unscheduled / S2 / S3 / S4 / S5 / S6 / S7 / S8 / S9 --><br />
| legal_CA = <br />
| legal_UK = <br />
| legal_US = <br />
| legal_status = <br />
| routes_of_administration = <br />
| class = [[孕激素]]、[[神经甾体]]<br />
<br />
<!--Pharmacokinetic data--><br />
| bioavailability = <br />
| protein_bound = <br />
| metabolism = <br />
| elimination_half-life = <br />
| excretion = <br />
<br />
<!-- Identifiers --><br />
| CAS_number_Ref = <br />
| CAS_number = 1185297-01-1<br />
| CAS_supplemental = <br />
| ATC_prefix = <br />
| ATC_suffix = <br />
| ATC_supplemental = <br />
| PubChem = 44219330<br />
| IUPHAR_ligand = <br />
| DrugBank_Ref = <br />
| DrugBank = <br />
| ChemSpiderID_Ref = <br />
| ChemSpiderID = 25052147<br />
| UNII = <br />
| KEGG = <br />
| ChEBI = <br />
| ChEMBL = 565873<br />
<br />
<!--Chemical data--><br />
| C=26 | H=40 | N=2 | O=3 <br />
| SMILES = CC(C)[C@@H](C(=O)O/N=C/1\CC[C@@]2([C@H]3CC[C@]4([C@H]([C@@H]3CCC2=C1)CC[C@@H]4C(=O)C)C)C)N<br />
| StdInChI_Ref = <br />
| StdInChI = 1S/C26H40N2O3/c1-15(2)23(27)24(30)31-28-18-10-12-25(4)17(14-18)6-7-19-21-9-8-20(16(3)29)26(21,5)13-11-22(19)25/h14-15,19-23H,6-13,27H2,1-5H3/b28-18+/t19-,20+,21-,22-,23-,25-,26+/m0/s<br />
| StdInChIKey_Ref = <br />
| StdInChIKey = JFIPYWOCXPCAFX-NPRMJFGVSA-N<br />
| synonyms = (3''E'')-3-({[(2''S'')-2-Amino-3-methylbutanoyl]oxy}imino)pregn-4-en-20-one <br />
}}<br />
'''{{PAGENAME}}'''（化学名：孕甾-4-烯-3,20-二酮 3-''O''-(<small>L</small>-缬氨酰)-''E''-肟，{{langx|en|pregn-4-ene-3,20-dione 3-''O''-(<small>L</small>-valine)-''E''-oxime}}）是一种含氮[[有机化合物]]，化学式[[C26H40N2O3|{{chem2|C26H40N2O3}}]]，属于人工合成的[[孕激素]]和[[神经甾体]]<ref name="pmid19791804">{{cite journal | vauthors = MacNevin CJ, Atif F, Sayeed I, Stein DG, Liotta DC | title = Development and screening of water-soluble analogues of progesterone and allopregnanolone in models of brain injury | journal = J. Med. Chem. | volume = 52 | issue = 19 | pages = 6012–23 | year = 2009 | pmid = 19791804 | doi = 10.1021/jm900712n }}</ref><ref name="pmid24900479">{{cite journal | vauthors = Guthrie DB, Stein DG, Liotta DC, Lockwood MA, Sayeed I, Atif F, Arrendale RF, Reddy GP, Evers TJ, Marengo JR, Howard RB, Culver DG, Natchus MG | title = Water-soluble progesterone analogues are effective, injectable treatments in animal models of traumatic brain injury | journal = ACS Med Chem Lett | volume = 3 | issue = 5 | pages = 362–6 | year = 2012 | pmid = 24900479 | pmc = 4025794 | doi = 10.1021/ml200303r }}</ref>。<br />
<br />
==参考文献==<br />
{{reflist}}<br />
<br />
[[Category:GABAA受体正向变构调节剂]]<br />
[[Category:酮]]<br />
[[Category:神经甾体]]<br />
[[Category:孕烷]]<br />
[[Category:前药]]<br />
[[Category:孕激素类]]<br />
[[Category:肟酯]]</div>
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