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OSU-6162 - 版本历史
2026-07-18T02:39:08Z
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<p><b>新页面</b></p><div>{{Drugbox<br />
| IUPAC_name = (3S)-3-[3-(methylsulfonyl)phenyl]-1-propylpiperidine<br />
| image = OSU-6162.svg<br />
| width = 220<br />
<br />
<!--Clinical data--><br />
| tradename = <br />
| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X --><br />
| pregnancy_US = <!-- A / B / C / D / X --><br />
| pregnancy_category = <br />
| legal_AU = <!-- Unscheduled / S2 / S3 / S4 / S5 / S6 / S7 / S8 / S9 --><br />
| legal_CA = <!-- / Schedule I, II, III, IV, V, VI, VII, VIII --><br />
| legal_UK = <!-- GSL / P / POM / CD / Class A, B, C --><br />
| legal_US = <!-- Schedule I ? --><br />
| legal_status = <br />
| routes_of_administration =<br />
<br />
<!--Pharmacokinetic data--><br />
| bioavailability = <br />
| protein_bound = <br />
| metabolism = <br />
| elimination_half-life = <br />
| excretion =<br />
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<!--Identifiers--><br />
| CAS_number = 156907-84-5<br />
| UNII_Ref = {{fdacite|correct|FDA}}<br />
| UNII = V5SBJBUJW6<br />
| ATC_prefix = none<br />
| ATC_suffix = <br />
| PubChem = 9795741<br />
| ChEMBL = 311730<br />
| ChemSpiderID = 7971507<br />
<br />
<!--Chemical data--><br />
| C=15 | H=23 | N=1 | O=2 | S=1<br />
| smiles = CCCN1CCC[C@H](C1)C2=CC(=CC=C2)S(=O)(=O)C<br />
| StdInChI = 1S/C15H23NO2S/c1-3-9-16-10-5-7-14(12-16)13-6-4-8-15(11-13)19(2,17)18/h4,6,8,11,14H,3,5,7,9-10,12H2,1-2H3/t14-/m1/s1<br />
| StdInChIKey = GZVBVBMMNFIXGE-CQSZACIVSA-N<br />
| synonyms = <br />
}}<br />
'''{{PAGENAME}}'''，也称为'''PNU-96391'''，是一种[[氮化合物|含氮]][[有机硫化合物]]，化学式[[C15H23NO2S|{{chem2|C15H23NO2S}}]]，结构上与[[普利多匹定]]（PL-101）类似，区别在于{{PAGENAME}}为[[3-苯基哌啶]]结构，而PL-101为[[4-苯基哌啶]]结构。{{PAGENAME}}可作为[[多巴胺受體D2|多巴胺受體D<sub>2</sub>]]和[[5-HT2A受体|5-HT<sub>2A</sub>受体]]的[[部分激动剂]]<ref>{{cite journal | vauthors = Ekesbo A, Andrén PE, Gunne LM, Tedroff J | title = (-)-OSU 6162 inhibits levodopa-induced dyskinesias in a monkey model of Parkinson's disease | journal = NeuroReport | volume = 8 | issue = 11 | pages = 2567–70 | date = July 1997 | pmid = 9261828 | doi = 10.1097/00001756-199707280-00029 | s2cid = 29806568 }}</ref><ref>{{cite journal | vauthors = Tedroff J, Torstenson R, Hartvig P, Sonesson C, Waters N, Carlsson A, Neu H, Fasth KJ, Långström B | display-authors = 6 | title = Effects of the substituted (S)-3-phenylpiperidine (-)-OSU6162 on PET measurements in subhuman primates: evidence for tone-dependent normalization of striatal dopaminergic activity | journal = Synapse | volume = 28 | issue = 4 | pages = 280–7 | date = April 1998 | pmid = 9517836 | doi = 10.1002/(SICI)1098-2396(199804)28:4<280::AID-SYN3>3.0.CO;2-5 | s2cid = 2090820 }}</ref><ref>{{cite journal | vauthors = Tedroff J, Ekesbo A, Sonesson C, Waters N, Carlsson A | title = Long-lasting improvement following (-)-OSU6162 in a patient with Huntington's disease | url = https://archive.org/details/sim_neurology_1999-10-22_53_7/page/1604 | journal = Neurology | volume = 53 | issue = 7 | pages = 1605–6 | date = October 1999 | pmid = 10534281 | doi = 10.1212/wnl.53.7.1605 }}</ref>。<br />
<br />
==参考文献==<br />
{{reflist}}<br />
<br />
[[Category:苯基砜]]<br />
[[Category:多巴胺激动剂]]<br />
[[Category:哌啶]]<br />
[[Category:甲磺酰基化合物]]<br />
[[Category:正丙基化合物]]</div>
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