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NS-398 - 版本历史
2026-07-20T02:17:14Z
本wiki上该页面的版本历史
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<p>使用<a href="/index.php?title=WP:HOTCAT&action=edit&redlink=1" class="new" title="WP:HOTCAT（页面不存在）">HotCat</a>已移除<a href="/wiki/Category:%E7%8E%AF%E5%B7%B1%E7%83%B7" title="Category:环己烷">Category:环己烷</a>; 已添加<a href="/wiki/Category:%E7%8E%AF%E5%B7%B1%E5%9F%BA%E5%8C%96%E5%90%88%E7%89%A9" title="Category:环己基化合物">Category:环己基化合物</a></p>
<p><b>新页面</b></p><div>{{chembox<br />
| Verifiedfields = changed<br />
| Watchedfields = changed<br />
| verifiedrevid = 424846904<br />
| Reference=<br />
| ImageFile=NS-398.png<br />
| ImageSize=180px<br />
| ImageFile1 = NS-398 molecule spacefill.png<br />
| ImageAlt1 = Space-filling model of the NS-398 molecule<br />
| PIN=''N''-[2-(Cyclohexyloxy)-4-nitrophenyl]methanesulfonamide<br />
| OtherNames=<br />
|Section1={{Chembox Identifiers<br />
| CASNo_Ref = {{cascite|correct|CAS}}<br />
| CASNo=123653-11-2<br />
| ChEBI_Ref = {{ebicite|correct|EBI}}<br />
| ChEBI = 73458<br />
| ChEMBL = 7162<br />
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}<br />
| ChemSpiderID = 4393<br />
| DrugBank = DB14060<br />
| IUPHAR_ligand = 8976<br />
| PubChem=4553<br />
| InChI = 1/C13H18N2O5S/c1-21(18,19)14-12-8-7-10(15(16)17)9-13(12)20-11-5-3-2-4-6-11/h7-9,11,14H,2-6H2,1H3<br />
| InChIKey = KTDZCOWXCWUPEO-UHFFFAOYAY<br />
| StdInChI_Ref = {{stdinchicite|correct|chemspider}}<br />
| StdInChI = 1S/C13H18N2O5S/c1-21(18,19)14-12-8-7-10(15(16)17)9-13(12)20-11-5-3-2-4-6-11/h7-9,11,14H,2-6H2,1H3<br />
| StdInChIKey_Ref = {{stdinchicite|changed|chemspider}}<br />
| StdInChIKey = KTDZCOWXCWUPEO-UHFFFAOYSA-N<br />
| SMILES=CS(=O)(=O)NC1=C(C=C(C=C1)[N+](=O)[O-])OC2CCCCC2<br />
}}<br />
|Section2={{Chembox Properties<br />
| C=13 | H=18 | N=2 | O=5 | S=1<br />
| Appearance=白色固体<br />
| Density=<br />
| MeltingPt=<br />
| BoilingPt=<br />
| Solubility=不溶<br />
| SolubleOther = 5 mg/mL<br />
| Solvent = [[DMSO]]<br />
}}<br />
|Section3={{Chembox Hazards<br />
| MainHazards=<br />
| FlashPt=<br />
| AutoignitionPt =<br />
| GHS_ref=<ref>{{cite web |title=N194 NS-398 |url=https://www.sigmaaldrich.com/AU/en/product/sigma/n194 |publisher=Sigma-Aldrich |access-date=13 December 2021}}</ref><br />
| GHSPictograms = {{GHS07}}<br />
| GHSSignalWord = Warning<br />
| HPhrases = {{H-phrases|302|312|332}}<br />
| PPhrases = {{P-phrases|280}}<br />
}}<br />
}}<br />
'''{{PAGENAME}}'''（化学式：[[C13H18N2O5S|C<sub>13</sub>H<sub>18</sub>N<sub>2</sub>O<sub>5</sub>S]]）是一种[[氮化合物|含氮]][[有机硫化合物]]，能作为COX-2的[[酶抑制剂]]，用于[[環氧合酶]]的科学研究<ref>{{cite journal | journal = American Journal of Pathology | year = 2005 | volume = 167 | issue = 4 | pages = 1105–1117 | title = NS-398, a Cyclooxygenase-2-Specific Inhibitor, Delays Skeletal Muscle Healing by Decreasing Regeneration and Promoting Fibrosis |author1=Wei Shen |author2=Yong Li |author3=Ying Tang |author4=James Cummins |author5=Johnny Huard | pmid = 16192645 | pmc = 1603662 | doi = 10.1016/S0002-9440(10)61199-6}}</ref>。<br />
<br />
==参考文献==<br />
{{reflist}}<br />
<br />
[[Category:COX-2抑制劑]]<br />
[[Category:非甾体抗炎药]]<br />
[[Category:硝基苯衍生物]]<br />
[[Category:磺胺]]<br />
[[Category:苯醚]]<br />
[[Category:环己基化合物]]<br />
[[Category:甲磺酰基化合物]]</div>
imported>Htmlzycq