imported>Htmlzycq：使用HotCat已移除Category:苯酚; 已添加Category:对羟苯基化合物

2025-02-14T18:21:35Z

使用HotCat已移除Category:苯酚; 已添加Category:对羟苯基化合物

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{{Drugbox
| Verifiedfields =
| Watchedfields =
| verifiedrevid =
| IUPAC_name = 4-(1-ethylpyrrolo[2,1,5-''cd'']indolizin-2-yl)phenol
| image = NNC 45-0095.svg
| width =


| tradename =
| pregnancy_AU = 
| pregnancy_US = 
| pregnancy_category =
| legal_AU = 
| legal_CA =
| legal_UK =
| legal_US =
| legal_status =
| routes_of_administration =
| class = [[選擇性雌激素受體調節物]]


| bioavailability =
| protein_bound =
| metabolism =
| elimination_half-life =
| excretion =


| CAS_number_Ref =
| CAS_number = 217318-90-6
| CAS_supplemental =
| ATC_prefix =
| ATC_suffix =
| ATC_supplemental =
| PubChem = 9903336
| IUPHAR_ligand =
| DrugBank_Ref =
| DrugBank =
| ChemSpiderID_Ref =
| ChemSpiderID = 8078990
| UNII = IS4M82C29X
| KEGG =
| ChEBI =
| ChEMBL = 420017
| synonyms = NNC-450095


| C=18 | H=15 | N=1 | O=1
| SMILES = CCC1=C(C2=CC=C3N2C1=CC=C3)C4=CC=C(C=C4)O
| StdInChI_Ref =
| StdInChI = 1S/C18H15NO/c1-2-15-16-5-3-4-13-8-11-17(19(13)16)18(15)12-6-9-14(20)10-7-12/h3-11,20H,2H2,1H3
| StdInChIKey_Ref =
| StdInChIKey = GBHFDPQPLXKNIU-UHFFFAOYSA-N
}}
'''{{PAGENAME}}'''是一种含氮[[有机化合物]]，化学式[[C18H17NO|C<sub>18</sub>H<sub>17</sub>NO]]，可作为[[非甾体]][[選擇性雌激素受體調節物]]（SERMs），由[[诺和诺德]]开发，用于治疗[[骨質疏鬆症]]，从未上市销售。<ref name="pmid10714509">{{cite journal | vauthors = Jørgensen AS, Jacobsen P, Christiansen LB, Bury PS, Kanstrup A, Thorpe SM, Bain S, Naerum L, Wassermann K | display-authors = 6 | title = Synthesis and pharmacology of a novel pyrrolo[2,1,5-cd] indolizine (NNC 45-0095), a high affinity non-steroidal agonist for the estrogen receptor | journal = Bioorganic & Medicinal Chemistry Letters | volume = 10 | issue = 4 | pages = 399–402 | date = February 2000 | pmid = 10714509 | doi = 10.1016/S0960-894X(00)00015-9 }}</ref><ref name="SharmaKumar2014">{{cite journal| vauthors = Sharma V, Kumar V |title=Indolizine: a biologically active moiety|journal=Medicinal Chemistry Research|volume=23|issue=8|year=2014|pages=3593–3606|issn=1054-2523|doi=10.1007/s00044-014-0940-1|s2cid=2643469}}</ref><ref name="pmid14683521">{{cite journal | vauthors = Wallace OB, Richardson TI, Dodge JA | title = Estrogen receptor modulators: relationships of ligand structure, receptor affinity and functional activity | journal = Current Topics in Medicinal Chemistry | volume = 3 | issue = 14 | pages = 1663–1682 | date = 2003 | pmid = 14683521 | doi = 10.2174/1568026033451727 }}</ref><ref name="RahmanReitz2010">{{cite book | vauthors = Meegan MJ, Lloyd DG | chapter = Understanding the Molecular Mechanism of Action of Estrogen Receptor Modulators. Frontiers in Medicinal Chemistry-Online | date = January 2005 | volume = 2 | issue = 1 | pages = 183-231 (206) | veditors = Atta-ur-Rahman, Reitz AB |title=Frontiers in Medicinal Chemistry|chapter-url=https://books.google.com/books?id=tCyDoIHToBQC&pg=PA206 |publisher=Bentham Science Publishers|isbn=978-1-60805-205-9 }}</ref><ref name="AdisInsight">{{Cite web | url = https://adisinsight.springer.com/drugs/800014610 | title = NNC 450095 | work = AdisInsight | publisher = Springer Nature Switzerland AG | access-date = 2024-01-18 | archive-date = 2024-01-18 | archive-url = https://web.archive.org/web/20240118052507/https://adisinsight.springer.com/drugs/800014610 | dead-url = no }}</ref>

==参考文献==
{{reflist|30em}}

[[Category:中止研发的药物]]
[[Category:中氮茚]]
[[Category:对羟苯基化合物]]
[[Category:選擇性雌激素受體調節劑]]

NNC 45-0095 - 版本历史

imported>Htmlzycq：​使用HotCat已移除Category:苯酚; 已添加Category:对羟苯基化合物

imported>Htmlzycq：使用HotCat已移除Category:苯酚; 已添加Category:对羟苯基化合物