imported>Leiem：使用HotCat已添加Category:吡咯并嘧啶

2021-10-23T07:06:07Z

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{{Drugbox
| IUPAC_name = (2''R'',3''R'',4''R'',5''R'')-2-(4-Amino-7''H''-pyrrolo[2,3-''d'']pyrimidin-7-yl)-3-ethynyl-5-(hydroxymethyl)tetrahydrofuran-3,4-diol
| image = NITD008.svg

| tradename = NITD008
| legal_status =


| bioavailability =
| metabolism =
| elimination_half-life =
| excretion =


| CAS_number_Ref = {{cascite|correct|CAS}}
| CAS_number = 1044589-82-3
| PubChem = 44633776
| UNII_Ref = {{fdacite|correct|FDA}}
| UNII = LKI7T3WQ2E
| DrugBank_Ref = {{drugbankcite|correct|drugbank}}
| ChemSpiderID = 26376187
| ChEMBL = 1630221


| C=13 | H=14 | N=4 | O=4
| SMILES = C#C[C@]1([C@@H]([C@H](O[C@H]1N2C=CC3=C2N=CN=C3N)CO)O)O
| StdInChI=1S/C13H14N4O4/c1-2-13(20)9(19)8(5-18)21-12(13)17-4-3-7-10(14)15-6-16-11(7)17/h1,3-4,6,8-9,12,18-20H,5H2,(H2,14,15,16)/t8-,9-,12-,13-/m1/s1
| StdInChIKey = NKRAIOQPSBRMOV-NRMKKVEVSA-N

}}

'''NITD008'''是一种[[抗病毒药物]]，属于[[腺苷|腺苷类似物]]（一种{{le|核苷类似物|nucleoside analog}}）。它作为治疗{{le|黄病毒|flavivirus}}感染的潜在药物被开发，并显示出对很多相关病毒的广谱活性，如[[骨痛热症病毒]]、[[西尼羅河病毒]]、[[黄热病|黄热病病毒]]、{{le|波瓦桑病毒|Powassan virus}}、[[丙型肝炎病毒|丙肝病毒]]、{{le|克亚萨努尔森林病病毒}}、{{le|鄂木斯克出血热病毒|Omsk hemorrhagic fever virus}}和[[茲卡病毒]]。<ref>{{cite journal | vauthors = Yin Z, Chen YL, Schul W, Wang QY, Gu F, Duraiswamy J, Kondreddi RR, Niyomrattanakit P, Lakshminarayana SB, Goh A, Xu HY, Liu W, Liu B, Lim JY, Ng CY, Qing M, Lim CC, Yip A, Wang G, Chan WL, Tan HP, Lin K, Zhang B, Zou G, Bernard KA, Garrett C, Beltz K, Dong M, Weaver M, He H, Pichota A, Dartois V, Keller TH, Shi PY | display-authors = 6 | title = An adenosine nucleoside inhibitor of dengue virus | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 106 | issue = 48 | pages = 20435–9 | date = December 2009 | pmid = 19918064 | doi = 10.1073/pnas.0907010106 | pmc = 2787148 | doi-access = free | bibcode = 2009PNAS..10620435Y }}</ref><ref>{{cite journal | vauthors = Lo MK, Shi PY, Chen YL, Flint M, Spiropoulou CF | title = In vitro antiviral activity of adenosine analog NITD008 against tick-borne flaviviruses | journal = Antiviral Research | volume = 130 | pages = 46–9 | date = June 2016 | pmid = 27016316 | pmc = 5096641 | doi = 10.1016/j.antiviral.2016.03.013 }}</ref><ref>{{cite journal | vauthors = Deng YQ, Zhang NN, Li CF, Tian M, Hao JN, Xie XP, Shi PY, Qin CF | display-authors = 6 | title = Adenosine Analog NITD008 Is a Potent Inhibitor of Zika Virus | journal = Open Forum Infectious Diseases | volume = 3 | issue = 4 | pages = ofw175 | date = October 2016 | pmid = 27747251 | doi = 10.1093/ofid/ofw175 | pmc = 5063548 | doi-access = free }}</ref>然而，虽然NITD008在临床前的动物试验中显示出较大毒性，不适合人体试验，但是它仍被用于新型病毒性疾病治疗的研究中。<ref>{{cite journal | vauthors = Nelson J, Roe K, Orillo B, Shi PY, Verma S | title = Combined treatment of adenosine nucleoside inhibitor NITD008 and histone deacetylase inhibitor vorinostat represents an immunotherapy strategy to ameliorate West Nile virus infection | journal = Antiviral Research | volume = 122 | pages = 39–45 | date = October 2015 | pmid = 26225754 | pmc = 4853296 | doi = 10.1016/j.antiviral.2015.07.008 }}</ref>

== 参考文献 ==
{{Reflist|2}}

{{RNA antivirals}}

[[Category:核苷]]
[[Category:炔烴衍生物]]
[[Category:抗RNA病毒药物]]
[[Category:吡咯并嘧啶]]

NITD008 - 版本历史

imported>Leiem：​使用HotCat已添加Category:吡咯并嘧啶

imported>Leiem：使用HotCat已添加Category:吡咯并嘧啶