imported>SchlurcherBot：Bot: http → https

2026-01-27T23:44:56Z

Bot: http → https

新页面

{{Pfam box
|Name=Cell shape determining protein MreB/Mbl|Symbol=MreB
|InterPro=IPR004753
|image=MreB.png
|caption=MreB ({{PDB|1jce}})
|Pfam=PF06723
|CDD=cd10225
}}
'''MreB'''是一种[[原核细胞骨架]]，是[[真核生物]][[肌动蛋白]]的原核[[同源]]物<ref name="pmid25788699">{{cite journal | vauthors = Gunning PW, Ghoshdastider U, Whitaker S, Popp D, Robinson RC | title = The evolution of compositionally and functionally distinct actin filaments | journal = Journal of Cell Science | volume = 128 | issue = 11 | pages = 2009–2019 | date = June 2015 | pmid = 25788699 | doi = 10.1242/jcs.165563 | doi-access = free }}</ref>。几乎所有的非球形细菌都依赖MreB来确定它们的形状。 MreB在[[细胞膜|细胞质膜]]下组装成丝状结构的螺旋网络，覆盖细胞的整个长度<ref name="Kurner2004">{{cite journal | vauthors = Kürner J, Medalia O, Linaroudis AA, Baumeister W | title = New insights into the structural organization of eukaryotic and prokaryotic cytoskeletons using cryo-electron tomography | journal = Experimental Cell Research | volume = 301 | issue = 1 | pages = 38–42 | date = November 2004 | pmid = 15501443 | doi = 10.1016/j.yexcr.2004.08.005 }}</ref>。 MreB通过介导合成[[肽聚糖]]的酶的位置和活性来确定细胞形状，并通过作为细胞膜下的刚性细丝起作用，施加向外的压力来雕刻和支撑细胞<ref name="Gitai2005" />。 MreB从其正常的螺旋网络凝结，并在细胞分裂前在[[新月柄杆菌]]（''Caulobacter crescentus''）的隔膜（septum）处形成紧密环，这是一种机制被认为有助于定位其偏离中隔的隔膜<ref name="Gitai2004">{{cite journal | vauthors = Gitai Z, Dye N, Shapiro L | title = An actin-like gene can determine cell polarity in bacteria | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 101 | issue = 23 | pages = 8643–8 | date = June 2004 | pmid = 15159537 | pmc = 423248 | doi = 10.1073/pnas.0402638101 }}</ref>。 MreB对于极性细菌中的极性测定也很重要，因为它负责在新月柄杆菌中正确定位至少四种不同的极性蛋白<ref name="Gitai2004" />。
[[Image:Prokaryotic Cytoskeleton.png|thumb|lift|350px|[[新月柄杆菌]]的细胞骨架元件：原核细胞骨架元件与其真核生物中的同功物质的对比<ref name="Gitai2005">{{cite journal| author = Gitai, Z.| year = 2005| title = The New Bacterial Cell Biology: Moving Parts and Subcellular Architecture| journal = Cell| volume = 120| issue = 5| pages = 577–586| url = https://linkinghub.elsevier.com/retrieve/pii/S0092867405001935| doi = 10.1016/j.cell.2005.02.026| pmid = 15766522| access-date = 2014-01-09| archive-date = 2021-02-13| archive-url = https://web.archive.org/web/20210213215106/https://linkinghub.elsevier.com/retrieve/pii/S0092867405001935| dead-url = no}}</ref>]]

== 参考文献 ==
{{reflist}}
{{细胞骨架蛋白}}
[[Category:结构蛋白]]
[[Category:细胞骨架]]

MreB - 版本历史

imported>SchlurcherBot：​Bot: http → https

imported>SchlurcherBot：Bot: http → https