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MYO5B - 版本历史
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'''''MYO5B'''''是一个位于[[18號染色體|人类18号染色体]]上的基因，编码一种隶属[[肌凝蛋白]][[蛋白質超家族|超家族]]的-{非典型}-的[[肌凝蛋白]]肌凝蛋白-Vb（{{lang|en|Myosin-Ia}}）<ref name="pmid8884266">{{cite journal | vauthors = Hasson T, Skowron JF, Gilbert DJ, Avraham KB, Perry WL, Bement WM, Anderson BL, Sherr EH, Chen ZY, Greene LA, Ward DC, Corey DP, Mooseker MS, Copeland NG, Jenkins NA | title = Mapping of unconventional myosins in mouse and human | journal = Genomics | volume = 36 | issue = 3 | pages = 431–9 | date = Sep 1996 | pmid = 8884266 | doi = 10.1006/geno.1996.0488 }}</ref><ref name="pmid17462998">{{cite journal | vauthors = Swiatecka-Urban A, Talebian L, Kanno E, Moreau-Marquis S, Coutermarsh B, Hansen K, Karlson KH, Barnaby R, Cheney RE, Langford GM, Fukuda M, Stanton BA | title = Myosin Vb is required for trafficking of the cystic fibrosis transmembrane conductance regulator in Rab11a-specific apical recycling endosomes in polarized human airway epithelial cells | url = https://archive.org/details/sim_journal-of-biological-chemistry_2007-08-10_282_32/page/23724 | journal = The Journal of Biological Chemistry | volume = 282 | issue = 32 | pages = 23725–36 | date = Aug 2007 | pmid = 17462998 | doi = 10.1074/jbc.M608531200 }}</ref><ref name="entrez">{{cite web| title = Entrez Gene: MYO5B myosin VB| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4645| access-date = 2021-05-03| archive-date = 2010-12-05| archive-url = https://web.archive.org/web/20101205081110/http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene}}</ref><ref name="mueller">{{cite journal|vauthors=Müller T, Hess MW, Schiefermeier N, Pfaller K, Ebner HL, Heinz-Erian P, Ponstingl H, Partsch J, Röllinghoff B, Köhler H, Berger T, Lenhartz H, Schlenck B, Houwen RJ, Taylor CJ, Zoller H, Lechner S, Goulet O, Utermann G, Ruemmele FM, Huber LA, Janecke AR|date=Oct 2008|title=MYO5B mutations cause microvillus inclusion disease and disrupt epithelial cell polarity|journal=Nature Genetics|volume=40|issue=10|pages=1163–5|doi=10.1038/ng.225|pmid=18724368}}</ref>。<br />
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''MYO5B''基因的突变会导致细胞极性的异常，进而造成{{le|微绒毛包涵体病|microvillous inclusion disease}}<ref name="mueller"/>。此外，也有证据表明''MYO5B''基因与[[躁郁症]]有关<ref>{{cite journal | vauthors = Sklar P, Smoller JW, Fan J, Ferreira MA, Perlis RH, Chambert K, Nimgaonkar VL, McQueen MB, Faraone SV, Kirby A, de Bakker PI, Ogdie MN, Thase ME, Sachs GS, Todd-Brown K, Gabriel SB, Sougnez C, Gates C, Blumenstiel B, Defelice M, Ardlie KG, Franklin J, Muir WJ, McGhee KA, MacIntyre DJ, McLean A, VanBeck M, McQuillin A, Bass NJ, Robinson M, Lawrence J, Anjorin A, Curtis D, Scolnick EM, Daly MJ, Blackwood DH, Gurling HM, Purcell SM | title = Whole-genome association study of bipolar disorder | journal = Molecular Psychiatry | volume = 13 | issue = 6 | pages = 558–69 | date = Jun 2008 | pmid = 18317468 | doi = 10.1038/sj.mp.4002151 | pmc = 3777816 }}</ref>。<br />
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==参见==<br />
*[[肌凝蛋白]]<br />
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==参考资料==<br />
{{reflist}}<br />
{{细胞骨架蛋白}}<br />
{{biochem-stub}}<br />
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[[Category:细胞骨架]]</div>
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