imported>JimGrassroot：使用HotCat已添加Category:黏液素

2025-10-19T00:24:13Z

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'''''MUC7'''''是[[智人]]的[[蛋白质]]編碼[[基因]]的一部分，位於[[4號染色體|4號人類染色體]]的短臂<ref name="HGNC">{{cite web |url=http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=HGNC:7518 |title=HUGO Gene Nomenclature Commitee, HGNC:7518 |archive-url=https://web.archive.org/web/20150910112621/http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=HGNC:7518 |archive-date=2015-09-10 |access-date=2017-08-30 |language=en}}</ref>，負責編碼'''Mucin-7'''這一種蛋白質<ref name="pmid8838308">{{cite journal | vauthors = Bobek LA, Liu J, Sait SN, Shows TB, Bobek YA, Levine MJ | title = Structure and chromosomal localization of the human salivary mucin gene, MUC7 | journal = Genomics | volume = 31 | issue = 3 | pages = 277–82 | date = February 1996 | pmid = 8838308 | doi = 10.1006/geno.1996.0049 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: MUC7 mucin 7, secreted| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4589}}</ref>。該蛋白的多肽鏈長度為377個[[氨基酸]]，[[分子量]]為39,159<ref name="UniProt">{{cite web |url=http://www.uniprot.org/uniprot/Q8TAX7#sequences |title=UniProt, Q8TAX7 |access-date=2017-08-30 |archive-date=2016-09-22 |archive-url=https://web.archive.org/web/20160922231532/http://www.uniprot.org/uniprot/Q8TAX7#sequences |language=en}}</ref>。在其他動物，MUC7基因只見於大多數的[[胎盤動物]]；但在[[有袋類]]物種的基因卻找不到<ref name="Xu Pavlidis Thamadilok Redwood 2016"/>。

== 人類變異 ==
人類的基因攜帶有五個或六個[[串联重复]]版本；而在其他靈長類動物中，這個基因的重複次數，在[[大猩猩]]為4-5次，在[[黑猩猩]]為5次，[[猩猩屬]]物種則為6-7次，[[獼猴]]為8-10次，[[狒狒屬]]為10-11次，[[绿猴]]為11-12次<ref name="Xu Pavlidis Thamadilok Redwood 2016">{{cite journal | vauthors = Xu D, Pavlidis P, Thamadilok S, Redwood E, Fox S, Blekhman R, Ruhl S, Gokcumen O | title = Recent evolution of the salivary mucin MUC7 | journal = Scientific Reports | volume = 6 | pages = 31791 | date = August 2016 | pmid = 27558399 | pmc = 4997351 | doi = 10.1038/srep31791 | bibcode = 2016NatSR...631791X }} [[File:CC-BY icon.svg|50px]] This article contains quotations from this source, which is available under the [https://creativecommons.org/licenses/by/4.0/ Creative Commons Attribution 4.0 International (CC BY 4.0)] {{Wayback|url=https://creativecommons.org/licenses/by/4.0/ |date=20171016050101 }} license.</ref>。根據一項2017年由美國[[紐約州立大學水牛城分校]]研究人員及其他機構合作，透過分析人類[[唾液]]中MUC7黏蛋白的演化過程，生物學家發現在大約15萬年前，[[撒哈拉以南非洲]]的人類祖先曾與一種前所未知的原始人類有過基因交流；而這人種並不屬於今人的人類、以及[[尼安德特人]]與[[丹尼索瓦人]]，可能是直立人的一支，被生物學家冠以“幽靈人種”（''{{lang|en|ghost species}}''）的名稱<ref name="ettoday">{{cite news |url=https://www.ettoday.net/news/20170725/974335.htm |title=研究：部份人類祖先曾跟「幽靈人種」雜交交流是常態 |publisher=[[ETtoday新聞雲]] |date=2017-07-25 |access-date=2023-08-15 |language=zh-hant |archive-date=2023-08-15 |archive-url=https://web.archive.org/web/20230815123903/https://www.ettoday.net/news/20170725/974335.htm |dead-url=no }}</ref><ref name="xinhua">{{cite news |url=http://m.xinhuanet.com/2017-07/25/c_1121376625.htm |title=部分现代人祖先曾与未知“幽灵”人种杂交 |publisher=[[新华网|新华社]] |date=2017-07-25 |access-date=2023-08-15 |language=zh-hans |archive-date=2021-10-10 |archive-url=https://web.archive.org/web/20211010091354/http://m.xinhuanet.com/2017-07/25/c_1121376625.htm |dead-url=yes |language=zh-hans}}</ref>。

== 參考文獻 ==
{{reflist|30em}}

== 延伸閱讀 ==
{{refbegin | 2}}
* {{cite journal | vauthors = Zalewska A, Zwierz K, Zółkowski K, Gindzieński A | title = Structure and biosynthesis of human salivary mucins | journal = Acta Biochimica Polonica | volume = 47 | issue = 4 | pages = 1067–79 | year = 2002 | pmid = 11996097 | doi = 10.18388/abp.2000_3960| doi-access = free }}
* {{cite journal | vauthors = Bobek LA, Tsai H, Biesbrock AR, Levine MJ | title = Molecular cloning, sequence, and specificity of expression of the gene encoding the low molecular weight human salivary mucin (MUC7) | url = https://archive.org/details/sim_journal-of-biological-chemistry_1993-09-25_268_27/page/20562 | journal = The Journal of Biological Chemistry | volume = 268 | issue = 27 | pages = 20563–9 | date = September 1993 | doi = 10.1016/S0021-9258(20)80762-5 | pmid = 7690757 | doi-access = free }}
* {{cite journal | vauthors = Troxler RF, Iontcheva I, Oppenheim FG, Nunes DP, Offner GD | title = Molecular characterization of a major high molecular weight mucin from human sublingual gland | journal = Glycobiology | volume = 7 | issue = 7 | pages = 965–73 | date = October 1997 | pmid = 9363439 | doi = 10.1093/glycob/7.7.965 | doi-access = free }}
* {{cite journal | vauthors = Prakobphol A, Thomsson KA, Hansson GC, Rosen SD, Singer MS, Phillips NJ, Medzihradszky KF, Burlingame AL, Leffler H, Fisher SJ | title = Human low-molecular-weight salivary mucin expresses the sialyl lewisx determinant and has L-selectin ligand activity | journal = Biochemistry | volume = 37 | issue = 14 | pages = 4916–27 | date = April 1998 | pmid = 9538010 | doi = 10.1021/bi972612a }}
* {{cite journal | vauthors = Kirkbride HJ, Bolscher JG, Nazmi K, Vinall LE, Nash MW, Moss FM, Mitchell DM, Swallow DM | title = Genetic polymorphism of MUC7: allele frequencies and association with asthma | journal = European Journal of Human Genetics | volume = 9 | issue = 5 | pages = 347–54 | date = May 2001 | pmid = 11378823 | doi = 10.1038/sj.ejhg.5200642 | doi-access = free }}
* {{cite journal | vauthors = Guo JM, Zhang Y, Cheng L, Iwasaki H, Wang H, Kubota T, Tachibana K, Narimatsu H | title = Molecular cloning and characterization of a novel member of the UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase family, pp-GalNAc-T12 | journal = FEBS Letters | volume = 524 | issue = 1–3 | pages = 211–8 | date = July 2002 | pmid = 12135769 | doi = 10.1016/S0014-5793(02)03007-7 | s2cid = 84453381 | doi-access = free }}
* {{cite journal | vauthors = Cheng L, Tachibana K, Zhang Y, Guo J, Kahori Tachibana K, Kameyama A, Wang H, Hiruma T, Iwasaki H, Togayachi A, Kudo T, Narimatsu H | title = Characterization of a novel human UDP-GalNAc transferase, pp-GalNAc-T10 | journal = FEBS Letters | volume = 531 | issue = 2 | pages = 115–21 | date = November 2002 | pmid = 12417297 | doi = 10.1016/S0014-5793(02)03399-9 | s2cid = 221288147 | doi-access = free }}
* {{cite journal | vauthors = Banderas-Tarabay JA, Zacarías-D'Oleire IG, Garduño-Estrada R, Aceves-Luna E, González-Begné M | title = Electrophoretic analysis of whole saliva and prevalence of dental caries. A study in Mexican dental students | journal = Archives of Medical Research | volume = 33 | issue = 5 | pages = 499–505 | year = 2003 | pmid = 12459324 | doi = 10.1016/S0188-4409(02)00395-8 }}
* {{cite journal | vauthors = Wang H, Tachibana K, Zhang Y, Iwasaki H, Kameyama A, Cheng L, Guo J, Hiruma T, Togayachi A, Kudo T, Kikuchi N, Narimatsu H | title = Cloning and characterization of a novel UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase, pp-GalNAc-T14 | journal = Biochemical and Biophysical Research Communications | volume = 300 | issue = 3 | pages = 738–44 | date = January 2003 | pmid = 12507512 | doi = 10.1016/S0006-291X(02)02908-X }}
* {{cite journal | vauthors = Soares RV, Siqueira CC, Bruno LS, Oppenheim FG, Offner GD, Troxler RF | title = MG2 and lactoferrin form a heterotypic complex in salivary secretions | journal = Journal of Dental Research | volume = 82 | issue = 6 | pages = 471–5 | date = June 2003 | pmid = 12766201 | doi = 10.1177/154405910308200613 | s2cid = 23276142 }}
* {{cite journal | vauthors = Ge J, Catt DM, Gregory RL | title = Streptococcus mutans surface alpha-enolase binds salivary mucin MG2 and human plasminogen | url = https://archive.org/details/sim_infection-and-immunity_2004-11_72_11/page/6748 | journal = Infection and Immunity | volume = 72 | issue = 11 | pages = 6748–52 | date = November 2004 | pmid = 15501816 | pmc = 523000 | doi = 10.1128/IAI.72.11.6748-6752.2004 }}
* {{cite journal | vauthors = Grys TE, Siegel MB, Lathem WW, Welch RA | title = The StcE protease contributes to intimate adherence of enterohemorrhagic Escherichia coli O157:H7 to host cells | url = https://archive.org/details/sim_infection-and-immunity_2005-03_73_3/page/1295 | journal = Infection and Immunity | volume = 73 | issue = 3 | pages = 1295–303 | date = March 2005 | pmid = 15731026 | pmc = 1064933 | doi = 10.1128/IAI.73.3.1295-1303.2005 }}
* {{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | url = https://archive.org/details/sim_nature-uk_2005-10-20_437_7062/page/1172 | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | date = October 2005 | pmid = 16189514 | doi = 10.1038/nature04209 | bibcode = 2005Natur.437.1173R | s2cid = 4427026 }}
* {{cite journal | vauthors = Bruno LS, Li X, Wang L, Soares RV, Siqueira CC, Oppenheim FG, Troxler RF, Offner GD | title = Two-hybrid analysis of human salivary mucin MUC7 interactions | journal = Biochimica et Biophysica Acta (BBA) - Molecular Cell Research | volume = 1746 | issue = 1 | pages = 65–72 | date = October 2005 | pmid = 16203048 | doi = 10.1016/j.bbamcr.2005.08.007 | doi-access = free }}
* {{cite journal | vauthors = Li S, Intini G, Bobek LA | title = Modulation of MUC7 mucin expression by exogenous factors in airway cells in vitro and in vivo | journal = American Journal of Respiratory Cell and Molecular Biology | volume = 35 | issue = 1 | pages = 95–102 | date = July 2006 | pmid = 16514118 | pmc = 2658701 | doi = 10.1165/rcmb.2005-0305OC }}
{{refend}}

== 外部連結 ==
[[Category:糖蛋白]]
[[Category:单次跨膜蛋白]]
[[Category:黏液素]]

MUC7 - 版本历史

imported>JimGrassroot：​使用HotCat已添加Category:黏液素

imported>JimGrassroot：使用HotCat已添加Category:黏液素