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'''MKL/megakaryoblastic leukemia 1'''（巨核细胞白血病）化学式为：C4334H7009O1388N1201S24<ref>{{Cite web |title=Expasy - ProtParam |url=https://web.expasy.org/cgi-bin/protparam/protparam_bis.cgi?Q969V6@1-931@ |website=web.expasy.org |access-date=2026-02-10}}</ref>是一种由人类[[基因]] ''MKL1'' 编码的[[蛋白质]]。<ref name="pmid11431691">{{cite journal | author = Ma Z, Morris SW, Valentine V, Li M, Herbrick JA, Cui X, Bouman D, Li Y, Mehta PK, Nizetic D, Kaneko Y, Chan GC, Chan LC, Squire J, Scherer SW, Hitzler JK | title = Fusion of two novel genes, RBM15 and MKL1, in the t(1;22)(p13;q13) of acute megakaryoblastic leukemia | journal = Nat Genet | volume = 28 | issue = 3 | pages = 220–1 |date=Jun 2001 | pmid = 11431691 | pmc = | doi = 10.1038/90054 }}</ref><ref name="pmid12019265">{{cite journal | author = Sasazuki T, Sawada T, Sakon S, Kitamura T, Kishi T, Okazaki T, Katano M, Tanaka M, Watanabe M, Yagita H, Okumura K, Nakano H | title = Identification of a novel transcriptional activator, BSAC, by a functional cloning to inhibit tumor necrosis factor-induced cell death | url = https://archive.org/details/sim_journal-of-biological-chemistry_2002-08-09_277_32/page/28852 | journal = J Biol Chem | volume = 277 | issue = 32 | pages = 28853–60 |date=Aug 2002 | pmid = 12019265 | pmc = | doi = 10.1074/jbc.M203190200 }}</ref><ref name="pmid14970199">{{cite journal | author = Du KL, Chen M, Li J, Lepore JJ, Mericko P, Parmacek MS | title = Megakaryoblastic leukemia factor-1 transduces cytoskeletal signals and induces smooth muscle cell differentiation from undifferentiated embryonic stem cells | url = https://archive.org/details/sim_journal-of-biological-chemistry_2004-04-23_279_17/page/17578 | journal = J Biol Chem | volume = 279 | issue = 17 | pages = 17578–86 |date=Apr 2004 | pmid = 14970199 | pmc = | doi = 10.1074/jbc.M400961200 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: MKL1 megakaryoblastic leukemia (translocation) 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=57591| accessdate = }}</ref>

此基因编码的蛋白能与[[转录因子]][[心肌素]]（{{langx|en|myocardin}}，一种调控平滑肌细胞分化的关键转录因子）相互作用。此蛋白主要存在于细胞核中，帮助信号从细胞质到细胞核的转导。在一个特异的染色体易位中，此基因会与1号染色体上的[[RBM15|RNA结合基序蛋白15]]基因融合，这一易位与[[急性巨核细胞白血病]]相关。<ref name="entrez">{{cite web | title = Entrez Gene: MKL1 megakaryoblastic leukemia (translocation) 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=57591| accessdate = }}</ref>
==参考文献==
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==延伸阅读==
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| citations =
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*{{cite journal | author=Dunham I, Shimizu N, Roe BA, ''et al.'' |title=The DNA sequence of human chromosome 22. | url=https://archive.org/details/sim_nature-uk_1999-12-02_402_6761/page/488 |journal=Nature |volume=402 |issue= 6761 |pages= 489–95 |year= 1999 |pmid= 10591208 |doi= 10.1038/990031 }}
*{{cite journal | author=Nagase T, Kikuno R, Ishikawa KI, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=7 |issue= 1 |pages= 65–73 |year= 2000 |pmid= 10718198 |doi=10.1093/dnares/7.1.65 }}
*{{cite journal | author=Mercher T, Coniat MB, Monni R, ''et al.'' |title=Involvement of a human gene related to the Drosophila spen gene in the recurrent t(1;22) translocation of acute megakaryocytic leukemia. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 10 |pages= 5776–9 |year= 2001 |pmid= 11344311 |doi= 10.1073/pnas.101001498 | pmc=33289 }}
*{{cite journal | author=Wang D, Chang PS, Wang Z, ''et al.'' |title=Activation of cardiac gene expression by myocardin, a transcriptional cofactor for serum response factor. |journal=Cell |volume=105 |issue= 7 |pages= 851–62 |year= 2001 |pmid= 11439182 |doi=10.1016/S0092-8674(01)00404-4 }}
*{{cite journal | author=Wang DZ, Li S, Hockemeyer D, ''et al.'' |title=Potentiation of serum response factor activity by a family of myocardin-related transcription factors. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 23 |pages= 14855–60 |year= 2003 |pmid= 12397177 |doi= 10.1073/pnas.222561499 | pmc=137508 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Cen B, Selvaraj A, Burgess RC, ''et al.'' |title=Megakaryoblastic leukemia 1, a potent transcriptional coactivator for serum response factor (SRF), is required for serum induction of SRF target genes. | url=https://archive.org/details/sim_molecular-and-cellular-biology_2003-09_23_18/page/6597 |journal=Mol. Cell. Biol. |volume=23 |issue= 18 |pages= 6597–608 |year= 2003 |pmid= 12944485 |doi=10.1128/MCB.23.18.6597-6608.2003 | pmc=193697 }}
*{{cite journal | author=Selvaraj A, Prywes R |title=Megakaryoblastic leukemia-1/2, a transcriptional co-activator of serum response factor, is required for skeletal myogenic differentiation. |journal=J. Biol. Chem. |volume=278 |issue= 43 |pages= 41977–87 |year= 2004 |pmid= 14565952 |doi= 10.1074/jbc.M305679200 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
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*{{cite journal | author=Selvaraj A, Prywes R |title=Expression profiling of serum inducible genes identifies a subset of SRF target genes that are MKL dependent. |journal=BMC Mol. Biol. |volume=5|pages= 13 |year= 2005 |pmid= 15329155 |doi= 10.1186/1471-2199-5-13 | pmc=516031 }}
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*{{cite journal | author=Nakagawa K, Kuzumaki N |title=Transcriptional activity of megakaryoblastic leukemia 1 (MKL1) is repressed by SUMO modification. |journal=Genes Cells |volume=10 |issue= 8 |pages= 835–50 |year= 2005 |pmid= 16098147 |doi= 10.1111/j.1365-2443.2005.00880.x }}
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MKL1 - 版本历史

2026年2月10日 (二) 03:36 imported>曦城星月