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MEROPS - 版本历史
2026-07-15T11:17:04Z
在这个wiki上该页的修订历史
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imported>JimGrassroot：使用HotCat已添加Category:蛋白质分类
2025-10-15T13:18:24Z
<p>使用<a href="/index.php?title=WP:HOTCAT&action=edit&redlink=1" class="new" title="WP:HOTCAT（页面不存在）">HotCat</a>已添加<a href="/wiki/Category:%E8%9B%8B%E7%99%BD%E8%B4%A8%E5%88%86%E7%B1%BB" title="Category:蛋白质分类">Category:蛋白质分类</a></p>
<p><b>新页面</b></p><div>{{for|同樣名稱的鳥類分類|蜂虎屬}}<br />
{{infobox biodatabase<br />
|title = MEROPS<br />
|logo =<!--[[File:Sanger Logo.png|150px]]--><br />
|description = MEROPS: the database of [[proteolytic enzymes]], their substrates and inhibitors.<br />
|scope = <br />
|organism = <br />
|center = [[维康桑格研究所]]<br />
|laboratory =<br />
|author = Neil D Rawlings<br />
|pmid = Rawlings & al. (2012)<ref name="pmid22086950">{{cite journal |last=Rawlings|first=Neil D|authorlink=|author2=Barrett Alan J |author3=Bateman Alex |date=Jan 2012|title=MEROPS: the database of proteolytic enzymes, their substrates and inhibitors|journal = Nucleic Acids Res.|volume=40|issue=Database issue|pages=D343-50|publisher= |location = England| issn = | pmid = 22086950|doi = 10.1093/nar/gkr987| bibcode = | oclc =| id = | url = | pmc =3245014 |language = eng| format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref><br />
|released = 2010<br />
|standard = <br />
|format = <br />
|url = http://merops.sanger.ac.uk<br />
|download = <br />
|webservice = <br />
|sql = <br />
|sparql = <br />
|webapp = <br />
|standalone = <br />
|license = <br />
|versioning = <br />
|frequency = <br />
|curation = <br />
|bookmark =<br />
|version=<br />
}}<br />
'''MEROPS'''是一个关于[[蛋白酶]]（或称为肽酶）及其抑制剂的在线网络[[数据库]]<ref name="pmid19892822">{{cite journal |author=Rawlings ND, Barrett AJ, Bateman A |title=MEROPS: the peptidase database |journal=Nucleic Acids Res. |volume=38 |issue=Database issue |pages=D227–33 |date=January 2010 |pmid=19892822 |pmc=2808883 |doi=10.1093/nar/gkp971 |url=}}</ref>。它对蛋白酶的{{le|分类方案|classification scheme}}由Rawlings & Barrett在1993年提出<ref>Rawlings, N.D. & Barrett, A.J. (1993) Evolutionary families of peptidases. ''Biochem J'' 290, 205-218.</ref>，对蛋白抑制剂的由Rawlings ''et al.''在2004年提出<ref>Rawlings, N.D., Tolle, D.P. & Barrett, A.J. (2004) Evolutionary families of peptidase inhibitors. ''Biochem J'' 378, 705-716.</ref>。最新版本MEROPS 12.0于2017年9月发布<ref name="MEROPSrelnotes">{{cite web|url=https://www.ebi.ac.uk/merops/whatsnew.shtml|title=What's New in MEROPS?|accessdate=2018-03-23|archive-date=2020-06-30|archive-url=https://web.archive.org/web/20200630002923/https://www.ebi.ac.uk/merops/whatsnew.shtml|dead-url=no}}</ref>。<br />
<br />
== 总览 ==<br />
分类基于三级的和一级的结构层面的相似性。比较仅限于直接参与反应的那部分序列，其在肽酶的情况下必须包含[[活性位点]]，并且对于蛋白质抑制剂而言为反应位点。分类是分层次的：序列被编组成家族（families），家族组成氏族（clans）。 每个肽酶，家族和氏族都有一个独特的标识符。<br />
<br />
==另见==<br />
<!--<br />
* [[The Proteolysis Map]]<br />
* [[TopFIND]], a scientific database covering proteases, their cleavage site specificity, substrates, inhibitors and protein termini originating from their activity<br />
* [[PA clan]]--><br />
* [[蛋白质超家族]]<br />
* [[蛋白质家族]]<br />
* [[催化三联体]]<br />
<br />
== 参考文献 ==<br />
{{reflist}}<br />
<br />
==外部链接==<br />
*[http://merops.sanger.ac.uk MEROPS database] {{Wayback|url=http://merops.sanger.ac.uk/ |date=20061114180435 }}<br />
<br />
<br />
[[Category:生物學資料庫]]<br />
[[Category:分子生物学]]<br />
[[Category:肽酶]]<br />
[[Category:線上資料庫]]<br />
[[Category:蛋白质分类]]</div>
imported>JimGrassroot